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Tnni1 troponin I, skeletal, slow 1 [ Mus musculus (house mouse) ]

Gene ID: 21952, updated on 8-Dec-2022

Summary

Official Symbol
Tnni1provided by MGI
Official Full Name
troponin I, skeletal, slow 1provided by MGI
Primary source
MGI:MGI:105073
See related
Ensembl:ENSMUSG00000026418 AllianceGenome:MGI:105073
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
ssTnI; 2700018B22Rik
Summary
Predicted to enable actin binding activity and metal ion binding activity. Acts upstream of or within transition between fast and slow fiber and ventricular cardiac muscle tissue morphogenesis. Predicted to be part of troponin complex. Is expressed in several structures, including alimentary system; diaphragm; heart; nervous system; and skeletal musculature. Orthologous to human TNNI1 (troponin I1, slow skeletal type). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in limb E14.5 (RPKM 75.2), colon adult (RPKM 20.1) and 4 other tissues See more
Orthologs
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Genomic context

See Tnni1 in Genome Data Viewer
Location:
1 E4; 1 59.28 cM
Exon count:
13
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (135709252..135738727)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (135783033..135810989)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene cysteine and glycine-rich protein 1 Neighboring gene predicted gene, 53478 Neighboring gene pleckstrin homology like domain, family A, member 3 Neighboring gene ladinin Neighboring gene troponin T2, cardiac

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 
  • Endonuclease-mediated (2) 

Pathways from PubChem

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables actin binding IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
part_of troponin complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of troponin complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
troponin I, slow skeletal muscle

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001112702.1NP_001106173.1  troponin I, slow skeletal muscle

    See identical proteins and their annotated locations for NP_001106173.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AA271187, AK012258, AV124377, CR521220
    Consensus CDS
    CCDS48374.1
    UniProtKB/Swiss-Prot
    Q9WUZ5
    UniProtKB/TrEMBL
    A0A6P5Q772, A0A8C6HBT3
    Related
    ENSMUSP00000122925.2, ENSMUST00000154463.8
    Conserved Domains (1) summary
    pfam00992
    Location:15146
    Troponin
  2. NM_021467.5NP_067442.1  troponin I, slow skeletal muscle

    See identical proteins and their annotated locations for NP_067442.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AA230582, AK012258, AV124377, CR521220
    Consensus CDS
    CCDS48374.1
    UniProtKB/Swiss-Prot
    Q9WUZ5
    UniProtKB/TrEMBL
    A0A6P5Q772, A0A8C6HBT3
    Related
    ENSMUSP00000121966.2, ENSMUST00000152208.8
    Conserved Domains (1) summary
    pfam00992
    Location:15146
    Troponin

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    135709252..135738727
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036163551.1XP_036019444.1  troponin I, slow skeletal muscle isoform X1

    UniProtKB/Swiss-Prot
    Q9WUZ5
    UniProtKB/TrEMBL
    A0A6P5Q772, A0A8C6HBT3
    Conserved Domains (1) summary
    pfam00992
    Location:15146
    Troponin
  2. XM_011247974.4XP_011246276.1  troponin I, slow skeletal muscle isoform X1

    See identical proteins and their annotated locations for XP_011246276.1

    UniProtKB/Swiss-Prot
    Q9WUZ5
    UniProtKB/TrEMBL
    A0A6P5Q772, A0A8C6HBT3
    Conserved Domains (1) summary
    pfam00992
    Location:15146
    Troponin
  3. XM_006529382.4XP_006529445.1  troponin I, slow skeletal muscle isoform X1

    See identical proteins and their annotated locations for XP_006529445.1

    UniProtKB/Swiss-Prot
    Q9WUZ5
    UniProtKB/TrEMBL
    A0A6P5Q772, A0A8C6HBT3
    Conserved Domains (1) summary
    pfam00992
    Location:15146
    Troponin