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Tnks tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase [ Mus musculus (house mouse) ]

Gene ID: 21951, updated on 9-May-2024

Summary

Official Symbol
Tnksprovided by MGI
Official Full Name
tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymeraseprovided by MGI
Primary source
MGI:MGI:1341087
See related
Ensembl:ENSMUSG00000031529 AllianceGenome:MGI:1341087
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
ARTD5; TANK1; Parp5a; mTNKS1; 4930554K12Rik; D130072O21Rik
Summary
Predicted to enable histone binding activity; pentosyltransferase activity; and zinc ion binding activity. Predicted to be involved in several processes, including negative regulation of maintenance of mitotic sister chromatid cohesion, telomeric; protein ADP-ribosylation; and regulation of nucleobase-containing compound metabolic process. Predicted to act upstream of or within peptidyl-serine phosphorylation and peptidyl-threonine phosphorylation. Located in cytosol. Is expressed in central nervous system; dorsal root ganglion; and neural retina. Orthologous to human TNKS (tankyrase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis adult (RPKM 23.3), whole brain E14.5 (RPKM 14.7) and 28 other tissues See more
Orthologs
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Genomic context

See Tnks in Genome Data Viewer
Location:
8 A4; 8 21.16 cM
Exon count:
27
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (35296333..35432844, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (34829179..34965690, complement)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 46069 Neighboring gene STARR-seq mESC enhancer starr_21171 Neighboring gene STARR-positive B cell enhancer ABC_E8233 Neighboring gene STARR-positive B cell enhancer ABC_E6632 Neighboring gene STARR-positive B cell enhancer ABC_E6633 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:35867988-35868175 Neighboring gene STARR-positive B cell enhancer ABC_E1363 Neighboring gene dual specificity phosphatase 4 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:36008219-36008402 Neighboring gene STARR-positive B cell enhancer ABC_E558 Neighboring gene STARR-seq mESC enhancer starr_21179 Neighboring gene predicted gene, 34368 Neighboring gene STARR-seq mESC enhancer starr_21180 Neighboring gene predicted gene, 34419 Neighboring gene chromodomain helicase DNA binding protein 6 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Gene trapped (1) 
  • Targeted (2)  1 citation

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables NAD+ ADP-ribosyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables NAD+ ADP-ribosyltransferase activity ISO
Inferred from Sequence Orthology
more info
 
enables NAD+-protein ADP-ribosyltransferase activity ISO
Inferred from Sequence Orthology
more info
 
enables glycosyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables histone binding ISO
Inferred from Sequence Orthology
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables nucleotidyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
enables zinc ion binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cell division IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within mRNA transport IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of maintenance of mitotic sister chromatid cohesion, telomeric ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of telomere maintenance via telomere lengthening ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of telomeric DNA binding ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within peptidyl-serine phosphorylation ISO
Inferred from Sequence Orthology
more info
PubMed 
acts_upstream_of_or_within peptidyl-threonine phosphorylation ISO
Inferred from Sequence Orthology
more info
PubMed 
involved_in positive regulation of canonical Wnt signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of canonical Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of telomerase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of telomere capping IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of telomere capping ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of telomere maintenance via telomerase ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in protein auto-ADP-ribosylation ISO
Inferred from Sequence Orthology
more info
 
involved_in protein localization to chromosome, telomeric region IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in protein localization to chromosome, telomeric region ISO
Inferred from Sequence Orthology
more info
 
involved_in protein poly-ADP-ribosylation ISO
Inferred from Sequence Orthology
more info
 
involved_in protein polyubiquitination ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within protein transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
 
located_in chromosome IEA
Inferred from Electronic Annotation
more info
 
located_in chromosome, telomeric region ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in mitotic spindle pole ISO
Inferred from Sequence Orthology
more info
 
located_in nuclear body ISO
Inferred from Sequence Orthology
more info
 
located_in nuclear membrane ISO
Inferred from Sequence Orthology
more info
 
part_of nuclear pore IEA
Inferred from Electronic Annotation
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
poly [ADP-ribose] polymerase tankyrase-1
Names
ADP-ribosyltransferase diphtheria toxin-like 5
TRF1-interacting ankyrin-related ADP-ribose polymerase 1
protein poly-ADP-ribosyltransferase tankyrase-1
tankyrase I
tankyrase-1
NP_780300.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_175091.3NP_780300.2  poly [ADP-ribose] polymerase tankyrase-1

    See identical proteins and their annotated locations for NP_780300.2

    Status: VALIDATED

    Source sequence(s)
    AC122458, AK080913, BC057370
    Consensus CDS
    CCDS22242.1
    UniProtKB/Swiss-Prot
    Q6PFX9, Q8BX62
    Related
    ENSMUSP00000033929.5, ENSMUST00000033929.6
    Conserved Domains (8) summary
    cd09524
    Location:10171082
    SAM_tankyrase1,2; SAM domain of tankyrase1,2 subfamily
    smart00454
    Location:10231080
    SAM; Sterile alpha motif
    cd00204
    Location:669794
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd01438
    Location:10841306
    tankyrase_like; Tankyrases interact with the telomere reverse transcriptase complex (TERT). Tankyrase 1 poly-ADP-ribosylates Telomere Repeat Binding Factor 1 (TRF1) while Tankyrase 2 can poly-ADP-ribosylate itself or TRF1. The tankyrases also contain multiple ankyrin ...
    pfam00644
    Location:10981301
    PARP; Poly(ADP-ribose) polymerase catalytic domain
    pfam12796
    Location:681773
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:796850
    Ank_4; Ankyrin repeats (many copies)
    sd00045
    Location:364392
    ANK; ANK repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    35296333..35432844 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)