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Tnfsf8 tumor necrosis factor (ligand) superfamily, member 8 [ Mus musculus (house mouse) ]

Gene ID: 21949, updated on 2-Oct-2022

Summary

Official Symbol
Tnfsf8provided by MGI
Official Full Name
tumor necrosis factor (ligand) superfamily, member 8provided by MGI
Primary source
MGI:MGI:88328
See related
Ensembl:ENSMUSG00000028362 AllianceGenome:MGI:88328
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CD153; Cd30l; CD30LG; Tnlg3a
Summary
Predicted to enable cytokine activity and tumor necrosis factor receptor binding activity. Acts upstream of or within CD8-positive, alpha-beta T cell differentiation; defense response to Gram-positive bacterium; and positive regulation of transcription by RNA polymerase II. Predicted to be located in extracellular space and membrane. Predicted to be integral component of membrane. Orthologous to human TNFSF8 (TNF superfamily member 8). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Low expression observed in reference dataset See more
Orthologs
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Genomic context

See Tnfsf8 in Genome Data Viewer
Location:
4 C1; 4 34.06 cM
Exon count:
4
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (63749439..63779745, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (63831202..63861508, complement)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene predicted gene, 42294 Neighboring gene tumor necrosis factor (ligand) superfamily, member 15 Neighboring gene ribosomal protein L17, pseudogene 4 Neighboring gene RIKEN cDNA 8030451A03 gene Neighboring gene tenascin C

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1)  1 citation
  • Endonuclease-mediated (3) 

Pathways from PubChem

General gene information

Markers

Homology

General protein information

Preferred Names
tumor necrosis factor ligand superfamily member 8
Names
CD30 ligand
CD30-L
tumor necrosis factor ligand 3a

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_009403.3NP_033429.1  tumor necrosis factor ligand superfamily member 8

    See identical proteins and their annotated locations for NP_033429.1

    Status: PROVISIONAL

    Source sequence(s)
    AK030916
    Consensus CDS
    CCDS18264.1
    UniProtKB/Swiss-Prot
    P32972
    UniProtKB/TrEMBL
    A0A8C6IK59, Q544U1
    Related
    ENSMUSP00000030047.3, ENSMUST00000030047.3
    Conserved Domains (1) summary
    pfam00229
    Location:118235
    TNF; TNF(Tumour Necrosis Factor) family

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    63749439..63779745 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017320114.2XP_017175603.1  tumor necrosis factor ligand superfamily member 8 isoform X1

    Conserved Domains (1) summary
    pfam00229
    Location:95211
    TNF; TNF(tumor Necrosis Factor) family
  2. XM_036163967.1XP_036019860.1  tumor necrosis factor ligand superfamily member 8 isoform X2

    Conserved Domains (1) summary
    cl00147
    Location:118187
    TNF; Tumor Necrosis Factor; TNF superfamily members include the cytokines: TNF (TNF-alpha), LT (lymphotoxin-alpha, TNF-beta), CD40 ligand, Apo2L (TRAIL), Fas ligand, and osteoprotegerin (OPG) ligand. These proteins generally have an intracellular N-terminal ...