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Cd40lg CD40 ligand [ Mus musculus (house mouse) ]

Gene ID: 21947, updated on 11-Jan-2022

Summary

Official Symbol
Cd40lgprovided by MGI
Official Full Name
CD40 ligandprovided by MGI
Primary source
MGI:MGI:88337
See related
Ensembl:ENSMUSG00000031132
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
IGM; IMD3; Ly62; TRAP; gp39; CD154; Cd40l; HIGM1; Ly-62; T-BAM; CD40-L; Tnfsf5; Tnlg8b
Summary
Predicted to enable CD40 receptor binding activity and integrin binding activity. Involved in isotype switching. Acts upstream of or within B cell differentiation and regulation of immunoglobulin production. Located in external side of plasma membrane. Is expressed in Meckel's cartilage; dorsal root ganglion; and limb. Used to study inflammatory bowel disease and systemic lupus erythematosus. Human ortholog(s) of this gene implicated in several diseases, including Kawasaki disease; artery disease (multiple); autoimmune disease (multiple); combined T cell and B cell immunodeficiency (multiple); and hematologic cancer (multiple). Orthologous to human CD40LG (CD40 ligand). [provided by Alliance of Genome Resources, Nov 2021]
Expression
Biased expression in thymus adult (RPKM 2.5), mammary gland adult (RPKM 1.2) and 4 other tissues See more
Orthologs
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Genomic context

See Cd40lg in Genome Data Viewer
Location:
X A6; X 31.21 cM
Exon count:
5
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) X NC_000086.8 (56257503..56269402)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (57212143..57224042)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) X NC_000086.6 (54465320..54477219)

Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene vestigial like family member 1 Neighboring gene predicted gene 14718 Neighboring gene Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6 Neighboring gene small nucleolar RNA, C/D box 61 Neighboring gene RNA binding motif protein, X chromosome

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables CD40 receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables CD40 receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables cytokine activity IEA
Inferred from Electronic Annotation
more info
 
enables integrin binding ISO
Inferred from Sequence Orthology
more info
 
enables protein serine/threonine kinase activator activity ISO
Inferred from Sequence Orthology
more info
 
enables tumor necrosis factor receptor binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within B cell differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in B cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in CD40 signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in dendritic cell differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in immune response IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within immunoglobulin production IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in inflammatory response ISO
Inferred from Sequence Orthology
more info
 
involved_in integrin-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in isotype switching IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in platelet activation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of B cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of MHC class II biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of NF-kappaB transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of T cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of dendritic cell differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of endothelial cell apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of immune response to tumor cell ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of interferon-gamma production ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of interleukin-10 production ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of interleukin-12 production ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of interleukin-4 production ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of immunoglobulin production IDA
Inferred from Direct Assay
more info
PubMed 
involved_in signal transduction NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
located_in cell body ISO
Inferred from Sequence Orthology
more info
 
located_in cell projection ISO
Inferred from Sequence Orthology
more info
 
located_in cell surface ISO
Inferred from Sequence Orthology
more info
 
located_in external side of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
 
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
CD40 ligand
Names
T-cell antigen Gp39
TNF-related activation protein
tumor necrosis factor ligand 8b
tumor necrosis factor ligand superfamily member 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_011616.2NP_035746.2  CD40 ligand

    See identical proteins and their annotated locations for NP_035746.2

    Status: VALIDATED

    Source sequence(s)
    X65453
    Consensus CDS
    CCDS30152.1
    UniProtKB/Swiss-Prot
    P27548
    UniProtKB/TrEMBL
    Q0VEI3
    Related
    ENSMUSP00000033466.2, ENSMUST00000033466.2
    Conserved Domains (1) summary
    pfam00229
    Location:137260
    TNF; TNF(Tumour Necrosis Factor) family

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000086.8 Reference GRCm39 C57BL/6J

    Range
    56257503..56269402
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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