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Dedd death effector domain-containing [ Mus musculus (house mouse) ]

Gene ID: 21945, updated on 26-Sep-2022

Summary

Official Symbol
Deddprovided by MGI
Official Full Name
death effector domain-containingprovided by MGI
Primary source
MGI:MGI:1333874
See related
Ensembl:ENSMUSG00000013973 AllianceGenome:MGI:1333874
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
DEFT; KE05; FLDED1; Dedpro1; CASP8IP1
Summary
Enables DNA binding activity. Acts upstream of or within decidualization; extrinsic apoptotic signaling pathway via death domain receptors; and negative regulation of nitrogen compound metabolic process. Located in cytoplasm and nucleolus. Is expressed in central nervous system and retina. Orthologous to human DEDD (death effector domain containing). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis adult (RPKM 26.5), large intestine adult (RPKM 9.3) and 28 other tissues See more
Orthologs
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Genomic context

See Dedd in Genome Data Viewer
Location:
1 H3; 1 79.34 cM
Exon count:
11
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (171152229..171170069)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (171324661..171342501)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene ribosomal protein L27, pseudogene 1 Neighboring gene predicted gene, 25151 Neighboring gene predicted gene, 20045 Neighboring gene nitrilase 1 Neighboring gene prefoldin 2 Neighboring gene kelch domain containing 9 Neighboring gene nectin cell adhesion molecule 4

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1)  1 citation
  • Endonuclease-mediated (1) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in nucleolus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleolus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
death effector domain-containing protein
Names
tumor necrosis factor (ligand) superfamily, member 19

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001128609.1NP_001122081.1  death effector domain-containing protein

    See identical proteins and their annotated locations for NP_001122081.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) is the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC084821, AK009728, BM947911
    Consensus CDS
    CCDS15490.1
    UniProtKB/Swiss-Prot
    Q9R227, Q9Z1L3
    UniProtKB/TrEMBL
    A0A6P5QK76, Q3U001
    Related
    ENSMUSP00000106931.2, ENSMUST00000111300.8
    Conserved Domains (1) summary
    cd08790
    Location:22118
    DED_DEDD; Death Effector Domain of DEDD
  2. NM_001357550.1NP_001344479.1  death effector domain-containing protein

    Status: VALIDATED

    Source sequence(s)
    AC087229
    Consensus CDS
    CCDS15490.1
    UniProtKB/Swiss-Prot
    Q9R227
    UniProtKB/TrEMBL
    A0A6P5QK76, Q3U001
    Conserved Domains (1) summary
    cd08790
    Location:22118
    DED_DEDD; Death Effector Domain of DEDD
  3. NM_001357551.1NP_001344480.1  death effector domain-containing protein

    Status: VALIDATED

    Source sequence(s)
    AC087229
    Consensus CDS
    CCDS15490.1
    UniProtKB/Swiss-Prot
    Q9R227
    UniProtKB/TrEMBL
    A0A6P5QK76, Q3U001
    Related
    ENSMUSP00000095075.2, ENSMUST00000097467.8
    Conserved Domains (1) summary
    cd08790
    Location:22118
    DED_DEDD; Death Effector Domain of DEDD
  4. NM_001357552.1NP_001344481.1  death effector domain-containing protein

    Status: VALIDATED

    Source sequence(s)
    AC087229
    Consensus CDS
    CCDS15490.1
    UniProtKB/Swiss-Prot
    Q9R227
    UniProtKB/TrEMBL
    A0A6P5QK76, Q3U001
    Conserved Domains (1) summary
    cd08790
    Location:22118
    DED_DEDD; Death Effector Domain of DEDD
  5. NM_001357553.1NP_001344482.1  death effector domain-containing protein

    Status: VALIDATED

    Source sequence(s)
    AC087229
    Consensus CDS
    CCDS15490.1
    UniProtKB/Swiss-Prot
    Q9R227
    UniProtKB/TrEMBL
    A0A6P5QK76, Q3U001
    Conserved Domains (1) summary
    cd08790
    Location:22118
    DED_DEDD; Death Effector Domain of DEDD
  6. NM_011615.3NP_035745.3  death effector domain-containing protein

    See identical proteins and their annotated locations for NP_035745.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an internal 5' UTR exon, as compared to variant 1.
    Source sequence(s)
    AC084821, AK009728, BM947911
    Consensus CDS
    CCDS15490.1
    UniProtKB/Swiss-Prot
    Q9R227, Q9Z1L3
    UniProtKB/TrEMBL
    A0A6P5QK76, Q3U001
    Related
    ENSMUSP00000068419.5, ENSMUST00000064950.11
    Conserved Domains (1) summary
    cd08790
    Location:22118
    DED_DEDD; Death Effector Domain of DEDD

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    171152229..171170069
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006496739.4XP_006496802.1  death effector domain-containing protein isoform X1

    See identical proteins and their annotated locations for XP_006496802.1

    UniProtKB/Swiss-Prot
    Q9R227, Q9Z1L3
    UniProtKB/TrEMBL
    A0A6P5QK76, Q3U001
    Related
    ENSMUSP00000106930.2, ENSMUST00000111299.8
    Conserved Domains (1) summary
    cd08790
    Location:22118
    DED_DEDD; Death Effector Domain of DEDD
  2. XM_011238782.2XP_011237084.1  death effector domain-containing protein isoform X1

    See identical proteins and their annotated locations for XP_011237084.1

    UniProtKB/Swiss-Prot
    Q9R227, Q9Z1L3
    UniProtKB/TrEMBL
    A0A6P5QK76, Q3U001
    Conserved Domains (1) summary
    cd08790
    Location:22118
    DED_DEDD; Death Effector Domain of DEDD
  3. XM_006496741.5XP_006496804.1  death effector domain-containing protein isoform X1

    See identical proteins and their annotated locations for XP_006496804.1

    UniProtKB/Swiss-Prot
    Q9R227, Q9Z1L3
    UniProtKB/TrEMBL
    A0A6P5QK76, Q3U001
    Conserved Domains (1) summary
    cd08790
    Location:22118
    DED_DEDD; Death Effector Domain of DEDD