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Tnfsf11 tumor necrosis factor (ligand) superfamily, member 11 [ Mus musculus (house mouse) ]

Gene ID: 21943, updated on 18-Sep-2018

Summary

Official Symbol
Tnfsf11provided by MGI
Official Full Name
tumor necrosis factor (ligand) superfamily, member 11provided by MGI
Primary source
MGI:MGI:1100089
See related
Ensembl:ENSMUSG00000022015
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
ODF; OPGL; RANKL; Ly109l; Trance
Expression
Biased expression in thymus adult (RPKM 1.0), mammary gland adult (RPKM 0.5) and 8 other tissues See more
Orthologs

Genomic context

See Tnfsf11 in Genome Data Viewer
Location:
14 D3; 14 41.26 cM
Exon count:
5
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 14 NC_000080.6 (78277446..78308043, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 14 NC_000080.5 (78677253..78707850, complement)

Chromosome 14 - NC_000080.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 30608 Neighboring gene microRNA 1971 Neighboring gene predicted gene, 30662 Neighboring gene predicted gene, 18277

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
cytokine activity ISO
Inferred from Sequence Orthology
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
tumor necrosis factor receptor binding IEA
Inferred from Electronic Annotation
more info
 
tumor necrosis factor receptor superfamily binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
ERK1 and ERK2 cascade IDA
Inferred from Direct Assay
more info
PubMed 
TNFSF11-mediated signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
TNFSF11-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
activation of JUN kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
animal organ morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
bone development IMP
Inferred from Mutant Phenotype
more info
PubMed 
bone resorption IDA
Inferred from Direct Assay
more info
PubMed 
calcium ion homeostasis IGI
Inferred from Genetic Interaction
more info
PubMed 
calcium-mediated signaling IDA
Inferred from Direct Assay
more info
PubMed 
cell differentiation IEA
Inferred from Electronic Annotation
more info
 
cellular response to leukemia inhibitory factor IEP
Inferred from Expression Pattern
more info
PubMed 
cytokine-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
immune response IEA
Inferred from Electronic Annotation
more info
 
lymph node development TAS
Traceable Author Statement
more info
PubMed 
mammary gland alveolus development IMP
Inferred from Mutant Phenotype
more info
PubMed 
mammary gland epithelial cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
monocyte chemotaxis ISO
Inferred from Sequence Orthology
more info
 
multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
ossification IMP
Inferred from Mutant Phenotype
more info
PubMed 
osteoclast development IDA
Inferred from Direct Assay
more info
PubMed 
osteoclast differentiation IDA
Inferred from Direct Assay
more info
PubMed 
osteoclast differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
osteoclast differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
osteoclast differentiation ISO
Inferred from Sequence Orthology
more info
 
osteoclast proliferation IDA
Inferred from Direct Assay
more info
PubMed 
paracrine signaling IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of DNA-binding transcription factor activity IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signaling ISO
Inferred from Sequence Orthology
more info
 
positive regulation of I-kappaB kinase/NF-kappaB signaling IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of JNK cascade IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of MAP kinase activity ISO
Inferred from Sequence Orthology
more info
 
positive regulation of NF-kappaB transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
positive regulation of T cell activation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of bone resorption ISO
Inferred from Sequence Orthology
more info
 
positive regulation of corticotropin-releasing hormone secretion IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of fever generation by positive regulation of prostaglandin secretion IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of gene expression IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of homotypic cell-cell adhesion ISO
Inferred from Sequence Orthology
more info
 
positive regulation of intracellular signal transduction ISO
Inferred from Sequence Orthology
more info
 
positive regulation of osteoclast development IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of osteoclast differentiation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of osteoclast differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of osteoclast differentiation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of protein kinase B signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
protein homooligomerization IDA
Inferred from Direct Assay
more info
PubMed 
regulation of osteoclast differentiation IDA
Inferred from Direct Assay
more info
PubMed 
tooth eruption IMP
Inferred from Mutant Phenotype
more info
PubMed 
tumor necrosis factor-mediated signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
extracellular region IEA
Inferred from Electronic Annotation
more info
 
extracellular space IEA
Inferred from Electronic Annotation
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
tumor necrosis factor ligand superfamily member 11
Names
OPG ligand
TNF-related activation-induced cytokine
osteoclast differentiation factor
osteoprotegerin ligand
receptor activator of NF-kappaB ligand
receptor activator of nuclear factor kappa-B ligand
tumor necrosis factor-related activation-induced cytokine

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_011613.3NP_035743.2  tumor necrosis factor ligand superfamily member 11

    See identical proteins and their annotated locations for NP_035743.2

    Status: VALIDATED

    Source sequence(s)
    AF019048, AK159498
    Consensus CDS
    CCDS27294.1
    UniProtKB/Swiss-Prot
    O35235
    Related
    ENSMUSP00000022592.7, ENSMUST00000022592.7
    Conserved Domains (1) summary
    pfam00229
    Location:184312
    TNF; TNF(Tumour Necrosis Factor) family

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000080.6 Reference GRCm38.p4 C57BL/6J

    Range
    78277446..78308043 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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