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Tnfsf11 tumor necrosis factor (ligand) superfamily, member 11 [ Mus musculus (house mouse) ]

Gene ID: 21943, updated on 29-Jan-2023

Summary

Official Symbol
Tnfsf11provided by MGI
Official Full Name
tumor necrosis factor (ligand) superfamily, member 11provided by MGI
Primary source
MGI:MGI:1100089
See related
Ensembl:ENSMUSG00000022015 AllianceGenome:MGI:1100089
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
ODF; OPGL; RANKL; Ly109l; Trance
Summary
Enables identical protein binding activity and tumor necrosis factor receptor superfamily binding activity. Involved in several processes, including intracellular signal transduction; positive regulation of secretion by cell; and tumor necrosis factor-mediated signaling pathway. Acts upstream of or within several processes, including animal organ development; cellular response to cytokine stimulus; and positive regulation of intracellular signal transduction. Predicted to be located in cytoplasm; extracellular space; and plasma membrane. Predicted to be integral component of membrane. Is expressed in genitourinary system; hemolymphoid system; hindlimb long bone; and lymphatic system. Used to study autosomal recessive osteopetrosis 2 and osteoporosis. Human ortholog(s) of this gene implicated in autosomal recessive osteopetrosis 2 and osteoporosis. Orthologous to human TNFSF11 (TNF superfamily member 11). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in thymus adult (RPKM 1.0), mammary gland adult (RPKM 0.5) and 8 other tissues See more
Orthologs
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Genomic context

See Tnfsf11 in Genome Data Viewer
Location:
14 D3; 14 41.26 cM
Exon count:
5
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (78514886..78545483, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (78277446..78308043, complement)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 30608 Neighboring gene microRNA 1971 Neighboring gene predicted gene, 30662 Neighboring gene predicted gene, 18277

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cytokine activity ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables tumor necrosis factor receptor binding IEA
Inferred from Electronic Annotation
more info
 
enables tumor necrosis factor receptor superfamily binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in ERK1 and ERK2 cascade IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of I-kappaB kinase/NF-kappaB signaling IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of JNK cascade IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within TNFSF11-mediated signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in TNFSF11-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within animal organ morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within bone development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within bone resorption IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within calcium ion homeostasis IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in calcium-mediated signaling IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within cell differentiation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cellular response to leukemia inhibitory factor IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in cytokine-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in immune response IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within lymph node development TAS
Traceable Author Statement
more info
PubMed 
acts_upstream_of_or_within mammary gland alveolus development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within mammary gland epithelial cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in monocyte chemotaxis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within ossification IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within osteoclast development IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of osteoclast differentiation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within osteoclast differentiation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of osteoclast differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within osteoclast differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in osteoclast differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in osteoclast differentiation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within osteoclast proliferation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within paracrine signaling IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of DNA-binding transcription factor activity IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signaling ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of I-kappaB kinase/NF-kappaB signaling IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of JNK cascade IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of MAP kinase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of NF-kappaB transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of T cell activation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of bone resorption ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of corticotropin-releasing hormone secretion IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of fever generation by positive regulation of prostaglandin secretion IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of gene expression IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of homotypic cell-cell adhesion ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of intracellular signal transduction ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of osteoclast development IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of osteoclast differentiation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of osteoclast differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of osteoclast differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of protein kinase B signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of protein kinase B signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of actin binding IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within regulation of osteoclast differentiation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within tooth eruption IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in tumor necrosis factor-mediated signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
tumor necrosis factor ligand superfamily member 11
Names
OPG ligand
TNF-related activation-induced cytokine
osteoclast differentiation factor
osteoprotegerin ligand
receptor activator of NF-kappaB ligand
receptor activator of nuclear factor kappa-B ligand
tumor necrosis factor-related activation-induced cytokine

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_011613.4NP_035743.2  tumor necrosis factor ligand superfamily member 11

    See identical proteins and their annotated locations for NP_035743.2

    Status: VALIDATED

    Source sequence(s)
    AC126690
    Consensus CDS
    CCDS27294.1
    UniProtKB/Swiss-Prot
    O35235, Q9R1Y0
    Related
    ENSMUSP00000022592.8, ENSMUST00000022592.8
    Conserved Domains (1) summary
    pfam00229
    Location:184312
    TNF; TNF(Tumour Necrosis Factor) family

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    78514886..78545483 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)