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Tnfrsf11a tumor necrosis factor receptor superfamily, member 11a, NFKB activator [ Mus musculus (house mouse) ]

Gene ID: 21934, updated on 26-Jun-2024

Summary

Official Symbol
Tnfrsf11aprovided by MGI
Official Full Name
tumor necrosis factor receptor superfamily, member 11a, NFKB activatorprovided by MGI
Primary source
MGI:MGI:1314891
See related
Ensembl:ENSMUSG00000026321 AllianceGenome:MGI:1314891
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
OFE; ODFR; Rank; Ly109; mRANK; TRANCE-R
Summary
Enables tumor necrosis factor-activated receptor activity. Involved in several processes, including circadian temperature homeostasis; positive regulation of fever generation by positive regulation of prostaglandin secretion; and tumor necrosis factor-mediated signaling pathway. Acts upstream of or within several processes, including hematopoietic or lymphoid organ development; mammary gland alveolus development; and positive regulation of bone resorption. Located in cell surface. Is expressed in bladder and lymphatic system. Human ortholog(s) of this gene implicated in Paget's disease of bone; autosomal recessive osteopetrosis 7; bone development disease; familial expansile osteolysis; and osteoporosis. Orthologous to human TNFRSF11A (TNF receptor superfamily member 11a). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in colon adult (RPKM 20.9), duodenum adult (RPKM 8.1) and 10 other tissues See more
Orthologs
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Genomic context

See Tnfrsf11a in Genome Data Viewer
Location:
1 E2.1; 1 49.7 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (105708443..105777172)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (105780673..105849444)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E988 Neighboring gene RAB11 binding and LisH domain, coiled-coil and HEAT repeat containing Neighboring gene predicted gene 10193 Neighboring gene predicted gene, 41926 Neighboring gene predicted gene, 41927

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cytokine binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables cytokine binding ISO
Inferred from Sequence Orthology
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables transmembrane signaling receptor activity ISO
Inferred from Sequence Orthology
more info
 
enables tumor necrosis factor receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables tumor necrosis factor receptor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
Process Evidence Code Pubs
involved_in adaptive immune response ISO
Inferred from Sequence Orthology
more info
 
involved_in circadian temperature homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in lymph node development IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within lymph node development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in mammary gland alveolus development IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within mammary gland alveolus development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within multicellular organism development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in multinuclear osteoclast differentiation IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within multinuclear osteoclast differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in ossification IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within ossification IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in osteoclast differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of DNA-binding transcription factor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of DNA-binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of ERK1 and ERK2 cascade ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of JUN kinase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of NF-kappaB transcription factor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of NF-kappaB transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of bone resorption IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within positive regulation of bone resorption IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of fever generation by positive regulation of prostaglandin secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of osteoclast differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to interleukin-1 IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in response to interleukin-1 IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to lipopolysaccharide IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to tumor necrosis factor IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in tumor necrosis factor-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in tumor necrosis factor-mediated signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in tumor necrosis factor-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in cell surface IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
is_active_in external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in external side of plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in membrane raft IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
tumor necrosis factor receptor superfamily member 11A
Names
osteoclast differentiation factor receptor
receptor activator of NF-KB
receptor activator of NF-kappaB

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_009399.5NP_033425.3  tumor necrosis factor receptor superfamily member 11A precursor

    See identical proteins and their annotated locations for NP_033425.3

    Status: VALIDATED

    Source sequence(s)
    AC101816, AC132123
    Consensus CDS
    CCDS15207.1
    UniProtKB/Swiss-Prot
    O35305, Q8VCT7
    Related
    ENSMUSP00000027559.7, ENSMUST00000027559.9
    Conserved Domains (1) summary
    cd13411
    Location:34196
    TNFRSF11A; Tumor necrosis factor receptor superfamily member 11A (TNFRSF11A), also known as receptor activator of nuclear factor-kappaB (RANK)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    105708443..105777172
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006529381.4XP_006529444.1  tumor necrosis factor receptor superfamily member 11A isoform X1

    Conserved Domains (2) summary
    cd00185
    Location:113153
    TNFRSF; CRD4 [structural motif]
    cl22855
    Location:104154
    TNFRSF; Tumor necrosis factor receptor superfamily (TNFRSF)