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Tnfrsf10b tumor necrosis factor receptor superfamily, member 10b [ Mus musculus (house mouse) ]

Gene ID: 21933, updated on 5-Jan-2023

Summary

Official Symbol
Tnfrsf10bprovided by MGI
Official Full Name
tumor necrosis factor receptor superfamily, member 10bprovided by MGI
Primary source
MGI:MGI:1341090
See related
Ensembl:ENSMUSG00000022074 AllianceGenome:MGI:1341090
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
MK; DR5; Ly98; KILLER; TRICKB; TRAILR2; TRICK2A; TRICK2B
Summary
Predicted to enable TRAIL receptor activity; identical protein binding activity; and protease binding activity. Predicted to be involved in TRAIL-activated apoptotic signaling pathway and positive regulation of apoptotic process. Predicted to act upstream of or within apoptotic process and regulation of apoptotic process. Predicted to be located in Golgi apparatus; cytosol; and membrane raft. Predicted to be active in cell surface and plasma membrane. Is expressed in bladder; liver; renal vasculature; urethra of female; and urethra of male. Human ortholog(s) of this gene implicated in carcinoma (multiple); cervical cancer; hematologic cancer (multiple); and urinary bladder cancer. Orthologous to several human genes including TNFRSF10A (TNF receptor superfamily member 10a). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in limb E14.5 (RPKM 3.6), subcutaneous fat pad adult (RPKM 3.3) and 25 other tissues See more
Orthologs
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Genomic context

See Tnfrsf10b in Genome Data Viewer
Location:
14; 14 D2
Exon count:
8
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (70004921..70021860)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (69767472..69784411)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4930480K23 gene Neighboring gene charged multivesicular body protein 7 Neighboring gene heat shock protein 1 (chaperonin) pseudogene Neighboring gene PR domain containing 4 pseudogene Neighboring gene Rho-related BTB domain containing 2 Neighboring gene phosphatidylethanolamine binding protein 4 Neighboring gene NSA2 ribosome biogenesis homolog pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (5)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables TRAIL binding RCA
inferred from Reviewed Computational Analysis
more info
PubMed 
enables TRAIL receptor activity ISO
Inferred from Sequence Orthology
more info
 
enables cysteine-type endopeptidase activator activity involved in apoptotic process RCA
inferred from Reviewed Computational Analysis
more info
PubMed 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables protease binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in TRAIL-activated apoptotic signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within apoptotic process RCA
inferred from Reviewed Computational Analysis
more info
PubMed 
involved_in extrinsic apoptotic signaling pathway via death domain receptors ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within regulation of apoptotic process RCA
inferred from Reviewed Computational Analysis
more info
PubMed 
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
 
is_active_in cell surface IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cell surface ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in membrane ISO
Inferred from Sequence Orthology
more info
 
located_in membrane raft ISO
Inferred from Sequence Orthology
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
tumor necrosis factor receptor superfamily member 10B
Names
KILLER/DR5 TRAIL death-inducing receptor
death receptor 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_020275.4NP_064671.2  tumor necrosis factor receptor superfamily member 10B precursor

    See identical proteins and their annotated locations for NP_064671.2

    Status: VALIDATED

    Source sequence(s)
    AK050753, BC065141
    Consensus CDS
    CCDS27243.1
    UniProtKB/Swiss-Prot
    Q9JJL6, Q9QZM4
    Related
    ENSMUSP00000022663.6, ENSMUST00000022663.7
    Conserved Domains (2) summary
    cd08315
    Location:276362
    Death_TRAILR_DR4_DR5; Death domain of Tumor necrosis factor-Related Apoptosis-Inducing Ligand Receptors
    cd10580
    Location:70170
    TNFRSF10; Tumor necrosis factor receptor superfamily member 10 (TNFRSF10), includes TNFRSF10A (DR4), TNFRSF10B (DR5), TNFRSF10C (DcR1) and TNFRSF10D (DcR2)

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    70004921..70021860
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036158575.1XP_036014468.1  tumor necrosis factor receptor superfamily member 10B isoform X1

    Conserved Domains (1) summary
    cd10580
    Location:70170
    TNFRSF10; Tumor necrosis factor receptor superfamily member 10 (TNFRSF10), includes TNFRSF10A (DR4), TNFRSF10B (DR5), TNFRSF10C (DcR1) and TNFRSF10D (DcR2)