Tnfaip6 tumor necrosis factor alpha induced protein 6 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Tnfaip6provided by MGI
Official Full Name: tumor necrosis factor alpha induced protein 6provided by MGI
Primary source: MGI:MGI:1195266
See related: Ensembl:ENSMUSG00000053475 AllianceGenome:MGI:1195266
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Tsg6; TSG-6; Tnfip6
Summary: Predicted to enable several functions, including carboxylesterase activity; fibronectin binding activity; and hyaluronic acid binding activity. Involved in ovarian cumulus expansion. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Human ortholog(s) of this gene implicated in corneal neovascularization. Orthologous to human TNFAIP6 (TNF alpha induced protein 6). [provided by Alliance of Genome Resources, Mar 2025]
Expression: Biased expression in limb E14.5 (RPKM 6.2), cerebellum adult (RPKM 4.1) and 11 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 C1.1; 2 29.98 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (51928125..51946693)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (52038113..52056681)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

TSG-6-Mediated Extracellular Matrix Modifications Regulate Hypoxic-Ischemic Brain Injury.
Title: TSG-6-Mediated Extracellular Matrix Modifications Regulate Hypoxic-Ischemic Brain Injury.
Endogenous TSG-6 modulates corneal inflammation following chemical injury.
Title: Endogenous TSG-6 modulates corneal inflammation following chemical injury.
TSG6 hyaluronan matrix remodeling dampens the inflammatory response during colitis.
Title: TSG6 hyaluronan matrix remodeling dampens the inflammatory response during colitis.
Characterization of the Involvement of Tumour Necrosis Factor (TNF)-alpha-Stimulated Gene 6 (TSG-6) in Ischemic Brain Injury Caused by Middle Cerebral Artery Occlusion in Mouse.
Title: Characterization of the Involvement of Tumour Necrosis Factor (TNF)-α-Stimulated Gene 6 (TSG-6) in Ischemic Brain Injury Caused by Middle Cerebral Artery Occlusion in Mouse.
Mesenchymal stem/stromal cells primed by inflammatory cytokines alleviate psoriasis-like inflammation via the TSG-6-neutrophil axis.
Title: Mesenchymal stem/stromal cells primed by inflammatory cytokines alleviate psoriasis-like inflammation via the TSG-6-neutrophil axis.
The Link module of human TSG-6 (Link_TSG6) promotes wound healing, suppresses inflammation and improves glandular function in mouse models of Dry Eye Disease.
Title: The Link module of human TSG-6 (Link_TSG6) promotes wound healing, suppresses inflammation and improves glandular function in mouse models of Dry Eye Disease.
Anti-inflammatory protein TNFalpha-stimulated gene-6 (TSG-6) reduces inflammatory response after brain injury in mice.
Title: Anti-inflammatory protein TNFα-stimulated gene-6 (TSG-6) reduces inflammatory response after brain injury in mice.
Cutaneous Wounds in Mice Lacking TSG-6 Exhibit Delayed Closure and an Abnormal Inflammatory Response.
Title: Cutaneous Wounds in Mice Lacking TSG-6 Exhibit Delayed Closure and an Abnormal Inflammatory Response.
Mesenchymal stem cells alleviate liver injury induced by chronic-binge ethanol feeding in mice via release of TSG6 and suppression of STAT3 activation.
Title: Mesenchymal stem cells alleviate liver injury induced by chronic-binge ethanol feeding in mice via release of TSG6 and suppression of STAT3 activation.
Tsg-6 is a key regulator for switching stemness and biological properties of mesenchymal stem cells.
Title: TNF-Stimulated Gene-6 Is a Key Regulator in Switching Stemness and Biological Properties of Mesenchymal Stem Cells.

Submit: New GeneRIF Correction See all GeneRIFs (40)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Targeted (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Tnfsg6 (e-PCR)
- UniSTS:254307

U83903 (e-PCR)
- UniSTS:158962

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables calcium ion binding	ISO Inferred from Sequence Orthology more info
enables calcium ion binding	ISS Inferred from Sequence or Structural Similarity more info
enables carboxylesterase activity	IEA Inferred from Electronic Annotation more info
enables carboxylesterase activity	ISO Inferred from Sequence Orthology more info
enables fibronectin binding	ISO Inferred from Sequence Orthology more info
enables fibronectin binding	ISS Inferred from Sequence or Structural Similarity more info
enables hyaluronic acid binding	ISO Inferred from Sequence Orthology more info
enables hyaluronic acid binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in cell adhesion	IEA Inferred from Electronic Annotation more info
involved_in fibronectin fibril organization	ISO Inferred from Sequence Orthology more info
involved_in fibronectin fibril organization	ISS Inferred from Sequence or Structural Similarity more info
involved_in hyaluronan metabolic process	ISO Inferred from Sequence Orthology more info
involved_in hyaluronan metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of BMP signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of BMP signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of inflammatory response	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of inflammatory response	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of inflammatory response	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of neutrophil chemotaxis	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of neutrophil chemotaxis	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of osteoblast differentiation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of osteoblast differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of osteoclast differentiation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of osteoclast differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in ovarian cumulus expansion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cell migration	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cell migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of receptor clustering	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of receptor clustering	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in extracellular region	ISO Inferred from Sequence Orthology more info
located_in extracellular region	ISS Inferred from Sequence or Structural Similarity more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IEA Inferred from Electronic Annotation more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: tumor necrosis factor-inducible gene 6 protein

Names: TNF alpha-induced protein 6; TNF-stimulated gene 6 protein; tumor necrosis factor induced protein 6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_009398.2 → NP_033424.1 tumor necrosis factor-inducible gene 6 protein precursor

See identical proteins and their annotated locations for NP_033424.1

Status: PROVISIONAL

Source sequence(s)

AL929138

Consensus CDS

CCDS16032.1

UniProtKB/Swiss-Prot

O08859

UniProtKB/TrEMBL

Q3USX6

Related

ENSMUSP00000069231.6, ENSMUST00000065927.6

Conserved Domains (2) summary

cd03515
Location:36 → 128

Link_domain_TSG_6_like; This is the extracellular link domain of the type found in human TSG-6. The link domain is a hyaluronan (HA)-binding domain. TSG-6 is the protein product of tumor necrosis factor-stimulated gene-6. TSG-6 is up-regulated in inflammatory lesions and in the ...

pfam00431
Location:135 → 244

CUB; CUB domain