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Tnfaip6 tumor necrosis factor alpha induced protein 6 [ Mus musculus (house mouse) ]

Gene ID: 21930, updated on 5-Mar-2024

Summary

Official Symbol
Tnfaip6provided by MGI
Official Full Name
tumor necrosis factor alpha induced protein 6provided by MGI
Primary source
MGI:MGI:1195266
See related
Ensembl:ENSMUSG00000053475 AllianceGenome:MGI:1195266
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Tsg6; TSG-6; Tnfip6
Summary
Predicted to enable hyaluronic acid binding activity. Predicted to be involved in negative regulation of inflammatory response. Predicted to be active in extracellular space. Human ortholog(s) of this gene implicated in corneal neovascularization. Orthologous to human TNFAIP6 (TNF alpha induced protein 6). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in limb E14.5 (RPKM 6.2), cerebellum adult (RPKM 4.1) and 11 other tissues See more
Orthologs
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Genomic context

See Tnfaip6 in Genome Data Viewer
Location:
2 C1.1; 2 29.98 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (51928125..51946693)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (52038113..52056681)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene chaperonin containing Tcp1, subunit 8 (theta) pseudogene Neighboring gene N-myc (and STAT) interactor Neighboring gene STARR-seq mESC enhancer starr_04475 Neighboring gene STARR-seq mESC enhancer starr_04477 Neighboring gene replication timing regulatory factor 1 Neighboring gene nebulin Neighboring gene STARR-seq mESC enhancer starr_04479 Neighboring gene RIKEN cDNA 4930573O16 gene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1)  1 citation
  • Endonuclease-mediated (3) 

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables calcium ion binding ISO
Inferred from Sequence Orthology
more info
 
enables carboxylesterase activity ISO
Inferred from Sequence Orthology
more info
 
enables fibronectin binding ISO
Inferred from Sequence Orthology
more info
 
enables hyaluronic acid binding ISO
Inferred from Sequence Orthology
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in extracellular region ISO
Inferred from Sequence Orthology
more info
 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
tumor necrosis factor-inducible gene 6 protein
Names
TNF alpha-induced protein 6
TNF-stimulated gene 6 protein
tumor necrosis factor induced protein 6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_009398.2NP_033424.1  tumor necrosis factor-inducible gene 6 protein precursor

    See identical proteins and their annotated locations for NP_033424.1

    Status: PROVISIONAL

    Source sequence(s)
    AL929138
    Consensus CDS
    CCDS16032.1
    UniProtKB/Swiss-Prot
    O08859
    UniProtKB/TrEMBL
    Q3USX6
    Related
    ENSMUSP00000069231.6, ENSMUST00000065927.6
    Conserved Domains (2) summary
    cd03515
    Location:36128
    Link_domain_TSG_6_like; This is the extracellular link domain of the type found in human TSG-6. The link domain is a hyaluronan (HA)-binding domain. TSG-6 is the protein product of tumor necrosis factor-stimulated gene-6. TSG-6 is up-regulated in inflammatory lesions and in the ...
    pfam00431
    Location:135244
    CUB; CUB domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    51928125..51946693
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)