U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

FARSA phenylalanyl-tRNA synthetase subunit alpha [ Homo sapiens (human) ]

Gene ID: 2193, updated on 9-Dec-2024

Summary

Official Symbol
FARSAprovided by HGNC
Official Full Name
phenylalanyl-tRNA synthetase subunit alphaprovided by HGNC
Primary source
HGNC:HGNC:3592
See related
Ensembl:ENSG00000179115 MIM:602918; AllianceGenome:HGNC:3592
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FRSA; CML33; FARSL; PheHA; FARSLA; RILDBC2
Summary
Aminoacyl-tRNA synthetases are a class of enzymes that charge tRNAs with their cognate amino acids. This gene encodes a product which is similar to the catalytic subunit of prokaryotic and Saccharomyces cerevisiae phenylalanyl-tRNA synthetases (PheRS). This gene product has been shown to be expressed in a tumor-selective and cell cycle stage- and differentiation-dependent manner, the first member of the tRNA synthetase gene family shown to exhibit this type of regulated expression [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in brain (RPKM 24.2), lymph node (RPKM 16.8) and 25 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See FARSA in Genome Data Viewer
Location:
19p13.13
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (12922479..12933711, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (13046966..13058199, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (13033293..13044525, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene glutaryl-CoA dehydrogenase Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr19:13010146-13011345 Neighboring gene synaptonemal complex central element protein 2 Neighboring gene CRISPRi-FlowFISH-validated KLF1 regulatory element 3 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:13021591-13021759 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:13022560-13023262 Neighboring gene Sharpr-MPRA regulatory region 4901 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14092 Neighboring gene microRNA 5695 Neighboring gene FARSA antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14093 Neighboring gene Sharpr-MPRA regulatory region 7930 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:13045760-13045865 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14095 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14096 Neighboring gene CRISPRi-FlowFISH-validated RAD23A regulatory element 2 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:13049721-13050470 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr19:13050707-13051906 Neighboring gene microRNA 6515 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:13056454-13057146 Neighboring gene calreticulin Neighboring gene Sharpr-MPRA regulatory region 11818 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr19:13058093-13059292 Neighboring gene RAD23 homolog A, nucleotide excision repair protein Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr19:13063321-13064520 Neighboring gene GADD45G interacting protein 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Rajab interstitial lung disease with brain calcifications 2
MedGen: C5436603 OMIM: 619013 GeneReviews: Not available
Compare labs

EBI GWAS Catalog

Description
Clozapine-induced agranulocytosis is associated with rare HLA-DQB1 and HLA-B alleles.
EBI GWAS Catalog
Genome wide association study (GWAS) of Chagas cardiomyopathy in Trypanosoma cruzi seropositive subjects.
EBI GWAS Catalog
Seventy-five genetic loci influencing the human red blood cell.
EBI GWAS Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables RNA binding HDA PubMed 
enables magnesium ion binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables phenylalanine-tRNA ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables phenylalanine-tRNA ligase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables tRNA binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in phenylalanyl-tRNA aminoacylation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in phenylalanyl-tRNA aminoacylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein heterotetramerization IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm NAS
Non-traceable Author Statement
more info
PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in membrane HDA PubMed 
part_of phenylalanine-tRNA ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of phenylalanine-tRNA ligase complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of phenylalanine-tRNA ligase complex IPI
Inferred from Physical Interaction
more info
PubMed 

General protein information

Preferred Names
phenylalanine--tRNA ligase alpha subunit
Names
pheRS
phenylalanine tRNA ligase 1, alpha, cytoplasmic
phenylalanine--tRNA ligase alpha chain
phenylalanine-tRNA synthetase alpha-subunit
phenylalanine-tRNA synthetase-like, alpha subunit
phenylalanyl-tRNA synthetase alpha chain
phenylalanyl-tRNA synthetase alpha subunit
phenylalanyl-tRNA synthetase-like, alpha subunit
NP_004452.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_004461.3NP_004452.1  phenylalanine--tRNA ligase alpha subunit

    See identical proteins and their annotated locations for NP_004452.1

    Status: VALIDATED

    Source sequence(s)
    AK130195, BC006495, U07424
    Consensus CDS
    CCDS12287.1
    UniProtKB/Swiss-Prot
    B4E363, Q9NSD8, Q9Y285, Q9Y4W8
    UniProtKB/TrEMBL
    K7ER00, Q6IBR2
    Related
    ENSP00000320309.3, ENST00000314606.9
    Conserved Domains (1) summary
    PTZ00326
    Location:1484
    PTZ00326; phenylalanyl-tRNA synthetase alpha chain; Provisional

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    12922479..12933711 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    13046966..13058199 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)