Format

Send to:

Choose Destination

FARSA phenylalanyl-tRNA synthetase subunit alpha [ Homo sapiens (human) ]

Gene ID: 2193, updated on 4-Nov-2018

Summary

Official Symbol
FARSAprovided by HGNC
Official Full Name
phenylalanyl-tRNA synthetase subunit alphaprovided by HGNC
Primary source
HGNC:HGNC:3592
See related
Ensembl:ENSG00000179115 MIM:602918; Vega:OTTHUMG00000180569
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FRSA; CML33; FARSL; PheHA; FARSLA
Summary
Aminoacyl-tRNA synthetases are a class of enzymes that charge tRNAs with their cognate amino acids. This gene encodes a product which is similar to the catalytic subunit of prokaryotic and Saccharomyces cerevisiae phenylalanyl-tRNA synthetases (PheRS). This gene product has been shown to be expressed in a tumor-selective and cell cycle stage- and differentiation-dependent manner, the first member of the tRNA synthetase gene family shown to exhibit this type of regulated expression [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in brain (RPKM 24.2), lymph node (RPKM 16.8) and 25 other tissues See more
Orthologs

Genomic context

See FARSA in Genome Data Viewer
Location:
19p13.13
Exon count:
12
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 19 NC_000019.10 (12922470..12933744, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (13033284..13044558, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene glutaryl-CoA dehydrogenase Neighboring gene synaptonemal complex central element protein 2 Neighboring gene microRNA 5695 Neighboring gene FARSA antisense RNA 1 Neighboring gene microRNA 6515 Neighboring gene calreticulin Neighboring gene RAD23 homolog A, nucleotide excision repair protein

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Clozapine-induced agranulocytosis is associated with rare HLA-DQB1 and HLA-B alleles.
NHGRI GWA Catalog
Genome wide association study (GWAS) of Chagas cardiomyopathy in Trypanosoma cruzi seropositive subjects.
NHGRI GWA Catalog
Seventy-five genetic loci influencing the human red blood cell.
NHGRI GWA Catalog

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
RNA binding HDA PubMed 
phenylalanine-tRNA ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
phenylalanine-tRNA ligase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
tRNA binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
phenylalanyl-tRNA aminoacylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
phenylalanyl-tRNA aminoacylation IDA
Inferred from Direct Assay
more info
PubMed 
protein heterotetramerization IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
membrane HDA PubMed 
phenylalanine-tRNA ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
phenylalanine-tRNA ligase complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
phenylalanine--tRNA ligase alpha subunit
Names
pheRS
phenylalanine tRNA ligase 1, alpha, cytoplasmic
phenylalanine--tRNA ligase alpha chain
phenylalanine-tRNA synthetase alpha-subunit
phenylalanine-tRNA synthetase-like, alpha subunit
phenylalanyl-tRNA synthetase alpha chain
phenylalanyl-tRNA synthetase alpha subunit
phenylalanyl-tRNA synthetase-like, alpha subunit
NP_004452.1
XP_024307187.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_004461.2NP_004452.1  phenylalanine--tRNA ligase alpha subunit

    See identical proteins and their annotated locations for NP_004452.1

    Status: VALIDATED

    Source sequence(s)
    AC092069, AK130195, BC006495, BG284015, U07424
    Consensus CDS
    CCDS12287.1
    UniProtKB/Swiss-Prot
    Q9Y285
    UniProtKB/TrEMBL
    Q6IBR2
    Related
    ENSP00000320309.3, OTTHUMP00000264636, ENST00000314606.8, OTTHUMT00000451935
    Conserved Domains (1) summary
    cl27322
    Location:1484
    PheS; Phenylalanyl-tRNA synthetase alpha subunit [Translation, ribosomal structure and biogenesis]

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p12 Primary Assembly

    Range
    12922470..12933744 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024451419.1XP_024307187.1  phenylalanine--tRNA ligase alpha subunit isoform X1

    Conserved Domains (1) summary
    cl27322
    Location:1545
    PheS; Phenylalanyl-tRNA synthetase alpha subunit [Translation, ribosomal structure and biogenesis]
Support Center