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Tnnc2 troponin C2, fast [ Mus musculus (house mouse) ]

Gene ID: 21925, updated on 26-Sep-2022

Summary

Official Symbol
Tnnc2provided by MGI
Official Full Name
troponin C2, fastprovided by MGI
Primary source
MGI:MGI:98780
See related
Ensembl:ENSMUSG00000017300 AllianceGenome:MGI:98780
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Tncs
Summary
Predicted to enable actin filament binding activity; calcium ion binding activity; and calcium-dependent protein binding activity. Predicted to contribute to actin binding activity. Predicted to be involved in regulation of muscle contraction and skeletal muscle contraction. Predicted to be part of troponin complex. Is expressed in several structures, including alimentary system; limb segment; skeletal musculature; urinary system; and urogenital ridge. Orthologous to human TNNC2 (troponin C2, fast skeletal type). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in mammary gland adult (RPKM 240.7), limb E14.5 (RPKM 66.2) and 4 other tissues See more
Orthologs
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Genomic context

See Tnnc2 in Genome Data Viewer
Location:
2; 2 H3
Exon count:
6
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (164619081..164621654, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (164777161..164779734, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene deoxynucleotidyltransferase, terminal, interacting protein 1 Neighboring gene ubiquitin-conjugating enzyme E2C Neighboring gene sorting nexin family member 21 Neighboring gene acyl-CoA thioesterase 8 Neighboring gene zinc finger SWIM-type containing 3

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
contributes_to actin binding ISO
Inferred from Sequence Orthology
more info
 
enables actin filament binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables calcium ion binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables calcium-dependent protein binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in regulation of muscle contraction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in skeletal muscle contraction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in skeletal muscle contraction ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
part_of troponin complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of troponin complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
troponin C, skeletal muscle
Names
STNC
troponin C, fast skeletal

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_009394.2NP_033420.1  troponin C, skeletal muscle

    See identical proteins and their annotated locations for NP_033420.1

    Status: VALIDATED

    Source sequence(s)
    BC024390, CB566378
    Consensus CDS
    CCDS17056.1
    UniProtKB/Swiss-Prot
    P20801
    UniProtKB/TrEMBL
    A0A6P5PA92, A0A8C6HVN9
    Related
    ENSMUSP00000099384.5, ENSMUST00000103095.5
    Conserved Domains (1) summary
    PTZ00184
    Location:12156
    PTZ00184; calmodulin; Provisional

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    164619081..164621654 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)