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Tmod1 tropomodulin 1 [ Mus musculus (house mouse) ]

Gene ID: 21916, updated on 5-Mar-2024

Summary

Official Symbol
Tmod1provided by MGI
Official Full Name
tropomodulin 1provided by MGI
Primary source
MGI:MGI:98775
See related
Ensembl:ENSMUSG00000028328 AllianceGenome:MGI:98775
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Tmod; E-Tmod
Summary
Enables tropomyosin binding activity. Involved in lens fiber cell development. Acts upstream of or within adult locomotory behavior; muscle contraction; and myofibril assembly. Located in cortical cytoskeleton; membrane; and sarcomere. Is expressed in several structures, including ganglia; heart; hemolymphoid system; musculature; and sensory organ. Used to study dilated cardiomyopathy. Orthologous to human TMOD1 (tropomodulin 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in heart adult (RPKM 56.3), liver E14 (RPKM 21.5) and 15 other tissues See more
Orthologs
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Genomic context

See Tmod1 in Genome Data Viewer
Location:
4 B1; 4 24.49 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (46038940..46116032)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (46038940..46116032)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene coiled-coil domain containing 180 Neighboring gene tudor domain containing 7 Neighboring gene predicted gene, 52729 Neighboring gene STARR-seq mESC enhancer starr_10118 Neighboring gene predicted gene, 54220 Neighboring gene thiosulfate sulfurtransferase (rhodanese)-like domain containing 2 Neighboring gene nuclear cap binding protein subunit 1 Neighboring gene STARR-seq mESC enhancer starr_10120 Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:46209123-46209232 Neighboring gene xeroderma pigmentosum, complementation group A

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC124125, MGC124126

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables actin binding ISO
Inferred from Sequence Orthology
more info
 
enables tropomyosin binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables tropomyosin binding IDA
Inferred from Direct Assay
more info
PubMed 
enables tropomyosin binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in actin filament organization IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within adult locomotory behavior IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in lens fiber cell development IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in muscle contraction IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within muscle contraction IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in myofibril assembly IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within myofibril assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in pointed-end actin filament capping IEA
Inferred from Electronic Annotation
more info
 
NOT acts_upstream_of_or_within skeletal muscle myosin thick filament assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
part_of COP9 signalosome ISO
Inferred from Sequence Orthology
more info
 
located_in actin filament ISO
Inferred from Sequence Orthology
more info
 
located_in cortical cytoskeleton IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
is_active_in cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoskeleton TAS
Traceable Author Statement
more info
PubMed 
located_in membrane IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in myofibril IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in myofibril IDA
Inferred from Direct Assay
more info
PubMed 
located_in myofibril ISO
Inferred from Sequence Orthology
more info
 
located_in sarcomere IDA
Inferred from Direct Assay
more info
PubMed 
located_in sarcomere ISO
Inferred from Sequence Orthology
more info
 
is_active_in striated muscle thin filament IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in striated muscle thin filament ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
tropomodulin-1
Names
erythrocyte tropomodulin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001424904.1NP_001411833.1  tropomodulin-1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL732615
  2. NM_001424905.1NP_001411834.1  tropomodulin-1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL732615
  3. NM_001424906.1NP_001411835.1  tropomodulin-1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL732615
  4. NM_001424907.1NP_001411836.1  tropomodulin-1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL732615
  5. NM_021883.3NP_068683.1  tropomodulin-1 isoform 1

    See identical proteins and their annotated locations for NP_068683.1

    Status: VALIDATED

    Source sequence(s)
    AL732615
    Consensus CDS
    CCDS18143.1
    UniProtKB/Swiss-Prot
    P49813, Q3KP84, Q9ERR9
    Related
    ENSMUSP00000103402.3, ENSMUST00000107773.3
    Conserved Domains (2) summary
    cd00116
    Location:195289
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    pfam03250
    Location:3143
    Tropomodulin; Tropomodulin

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    46038940..46116032
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006537772.5XP_006537835.1  tropomodulin-1 isoform X1

    Conserved Domains (2) summary
    pfam03250
    Location:3143
    Tropomodulin
    cl39015
    Location:195289
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...