U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Ccar2 cell cycle activator and apoptosis regulator 2 [ Mus musculus (house mouse) ]

Gene ID: 219158, updated on 12-May-2024

Summary

Official Symbol
Ccar2provided by MGI
Official Full Name
cell cycle activator and apoptosis regulator 2provided by MGI
Primary source
MGI:MGI:2444228
See related
Ensembl:ENSMUSG00000033712 AllianceGenome:MGI:2444228
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Dbc1; mKIAA1967; 2610301G19Rik
Summary
Enables enzyme inhibitor activity. Involved in negative regulation of catalytic activity and regulation of circadian rhythm. Predicted to be located in several cellular components, including mitochondrial matrix; nucleoplasm; and spindle. Predicted to be part of DBIRD complex. Predicted to be active in nucleus. Is expressed in several structures, including central nervous system and retina. Orthologous to human CCAR2 (cell cycle and apoptosis regulator 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 35.4), whole brain E14.5 (RPKM 35.1) and 28 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Ccar2 in Genome Data Viewer
Location:
14 D2; 14 36.24 cM
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (70375617..70391272, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (70138168..70153791, complement)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene early growth response 3 Neighboring gene CapStarr-seq enhancer MGSCv37_chr14:70499772-70499955 Neighboring gene bridging integrator 3 Neighboring gene RIKEN cDNA 9930012K11 gene Neighboring gene CapStarr-seq enhancer MGSCv37_chr14:70553578-70553761 Neighboring gene CapStarr-seq enhancer MGSCv37_chr14:70559515-70559758 Neighboring gene PDZ and LIM domain 2

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (5) 
  • Gene trapped (1) 
  • Targeted (1)  1 citation

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC7730

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA polymerase II complex binding ISO
Inferred from Sequence Orthology
more info
 
enables enzyme binding ISO
Inferred from Sequence Orthology
more info
 
enables enzyme inhibitor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables enzyme inhibitor activity ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within DNA damage response IEA
Inferred from Electronic Annotation
more info
 
involved_in RNA splicing ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within apoptotic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within mRNA processing IEA
Inferred from Electronic Annotation
more info
 
involved_in mitochondrial fragmentation involved in apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of catalytic activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of catalytic activity ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cell growth ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of proteasomal ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of DNA damage checkpoint ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of canonical Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in regulation of DNA-templated transcription elongation ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of circadian rhythm IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of protein deacetylation ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of protein stability ISO
Inferred from Sequence Orthology
more info
 
involved_in response to UV ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within rhythmic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
part_of DBIRD complex ISO
Inferred from Sequence Orthology
more info
 
part_of chromatin ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondrial matrix ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in spindle ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
cell cycle and apoptosis regulator protein 2
Names
cell division cycle and apoptosis regulator protein 2

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_146055.3NP_666167.3  cell cycle and apoptosis regulator protein 2

    See identical proteins and their annotated locations for NP_666167.3

    Status: VALIDATED

    Source sequence(s)
    AC151836
    Consensus CDS
    CCDS49534.1
    UniProtKB/Swiss-Prot
    Q6PIB1, Q8BWR5, Q8C0F0, Q8R3G6, Q8VDP4
    Related
    ENSMUSP00000036924.6, ENSMUST00000035612.7
    Conserved Domains (4) summary
    COG1196
    Location:811917
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    PRK13914
    Location:444494
    PRK13914; invasion associated endopeptidase
    pfam14443
    Location:343454
    DBC1
    pfam14444
    Location:55112
    S1-like

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    70375617..70391272 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006518897.5XP_006518960.1  cell cycle and apoptosis regulator protein 2 isoform X2

    Conserved Domains (4) summary
    COG1196
    Location:810916
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    PRK13914
    Location:444494
    PRK13914; invasion associated endopeptidase
    pfam14443
    Location:343454
    DBC1
    pfam14444
    Location:55112
    S1-like
  2. XM_006518896.5XP_006518959.1  cell cycle and apoptosis regulator protein 2 isoform X1

    See identical proteins and their annotated locations for XP_006518959.1

    UniProtKB/Swiss-Prot
    Q6PIB1, Q8BWR5, Q8C0F0, Q8R3G6, Q8VDP4
    Conserved Domains (4) summary
    COG1196
    Location:811917
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    PRK13914
    Location:444494
    PRK13914; invasion associated endopeptidase
    pfam14443
    Location:343454
    DBC1
    pfam14444
    Location:55112
    S1-like