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Hmbox1 homeobox containing 1 [ Mus musculus (house mouse) ]

Gene ID: 219150, updated on 21-May-2024

Summary

Official Symbol
Hmbox1provided by MGI
Official Full Name
homeobox containing 1provided by MGI
Primary source
MGI:MGI:2445066
See related
Ensembl:ENSMUSG00000021972 AllianceGenome:MGI:2445066
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
F830020C16Rik
Summary
Enables telomeric DNA binding activity. Involved in positive regulation of chromatin binding activity. Located in chromosome, telomeric region and nucleus. Is expressed in several structures, including central nervous system; early conceptus; female reproductive system; limb mesenchyme; and urinary system. Orthologous to human HMBOX1 (homeobox containing 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in lung adult (RPKM 16.3), thymus adult (RPKM 10.2) and 28 other tissues See more
Orthologs
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Genomic context

See Hmbox1 in Genome Data Viewer
Location:
14 D1; 14 33.79 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (65049049..65187354, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (64811600..64949899, complement)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene kinesin family member 13B Neighboring gene non-SMC element 2 homolog (MMS21, S. cerevisiae) pseudogene Neighboring gene predicted gene, 26225 Neighboring gene 60S ribosomal protein L35a pseudogene Neighboring gene CapStarr-seq enhancer MGSCv37_chr14:65534306-65534489 Neighboring gene CapStarr-seq enhancer MGSCv37_chr14:65568546-65568932 Neighboring gene high mobility group nucleosomal binding domain 2, pseudogene Neighboring gene integrator complex subunit 9 Neighboring gene STARR-positive B cell enhancer mm9_chr14:65644927-65645227 Neighboring gene predicted gene, 52118 Neighboring gene CapStarr-seq enhancer MGSCv37_chr14:65716318-65716519 Neighboring gene STARR-positive B cell enhancer ABC_E11573 Neighboring gene exostosin-like glycosyltransferase 3 Neighboring gene predicted gene, 52119

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Gene trapped (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables double-stranded telomeric DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein-containing complex binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
 
enables sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables sequence-specific double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables telomeric DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables telomeric DNA binding ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in centrosome ISO
Inferred from Sequence Orthology
more info
 
located_in chromosome IEA
Inferred from Electronic Annotation
more info
 
located_in chromosome, telomeric region IDA
Inferred from Direct Assay
more info
PubMed 
located_in chromosome, telomeric region ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in nuclear body ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
homeobox-containing protein 1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001347626.2NP_001334555.1  homeobox-containing protein 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC132602, AC141425
    Consensus CDS
    CCDS84150.1
    UniProtKB/TrEMBL
    H3BKF8, H3BKM3
    Related
    ENSMUSP00000135448.2, ENSMUST00000176128.8
    Conserved Domains (2) summary
    cd00086
    Location:268340
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
    pfam04814
    Location:25227
    HNF-1_N; Hepatocyte nuclear factor 1 (HNF-1), N-terminus
  2. NM_001347627.2NP_001334556.1  homeobox-containing protein 1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC132602, AC141425
    Consensus CDS
    CCDS84149.1
    UniProtKB/TrEMBL
    H3BK13
    Related
    ENSMUSP00000022544.8, ENSMUST00000022544.14
    Conserved Domains (2) summary
    cd00086
    Location:268340
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
    pfam04814
    Location:25227
    HNF-1_N; Hepatocyte nuclear factor 1 (HNF-1), N-terminus
  3. NM_177338.7NP_796312.2  homeobox-containing protein 1 isoform 2

    See identical proteins and their annotated locations for NP_796312.2

    Status: VALIDATED

    Source sequence(s)
    AC132602, AC141425
    Consensus CDS
    CCDS36955.1
    UniProtKB/Swiss-Prot
    Q80WC2, Q8BJA3, Q8BWE7, Q99LV1
    UniProtKB/TrEMBL
    H3BKF8
    Related
    ENSMUSP00000066905.4, ENSMUST00000067843.10
    Conserved Domains (2) summary
    cd00086
    Location:268340
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
    pfam04814
    Location:25227
    HNF-1_N; Hepatocyte nuclear factor 1 (HNF-1), N-terminus

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    65049049..65187354 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030247768.2XP_030103628.1  homeobox-containing protein 1 isoform X9

    UniProtKB/TrEMBL
    H3BK13
    Conserved Domains (2) summary
    cd00086
    Location:268340
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
    pfam04814
    Location:25227
    HNF-1_N; Hepatocyte nuclear factor 1 (HNF-1), N-terminus
  2. XM_030247767.2XP_030103627.1  homeobox-containing protein 1 isoform X9

    UniProtKB/TrEMBL
    H3BK13
    Conserved Domains (2) summary
    cd00086
    Location:268340
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
    pfam04814
    Location:25227
    HNF-1_N; Hepatocyte nuclear factor 1 (HNF-1), N-terminus
  3. XM_011245031.4XP_011243333.1  homeobox-containing protein 1 isoform X4

    UniProtKB/TrEMBL
    H3BKF8
    Conserved Domains (2) summary
    cd00086
    Location:268340
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
    pfam04814
    Location:25227
    HNF-1_N; Hepatocyte nuclear factor 1 (HNF-1), N-terminus
  4. XM_011245029.4XP_011243331.1  homeobox-containing protein 1 isoform X3

    UniProtKB/TrEMBL
    H3BKF8
    Conserved Domains (2) summary
    cd00086
    Location:268340
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
    pfam04814
    Location:25227
    HNF-1_N; Hepatocyte nuclear factor 1 (HNF-1), N-terminus
  5. XM_011245036.4XP_011243338.1  homeobox-containing protein 1 isoform X8

    See identical proteins and their annotated locations for XP_011243338.1

    UniProtKB/TrEMBL
    H3BK13
    Related
    ENSMUSP00000135211.2, ENSMUST00000176832.8
    Conserved Domains (2) summary
    cd00086
    Location:268340
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
    pfam04814
    Location:25227
    HNF-1_N; Hepatocyte nuclear factor 1 (HNF-1), N-terminus
  6. XM_011245035.4XP_011243337.1  homeobox-containing protein 1 isoform X8

    See identical proteins and their annotated locations for XP_011243337.1

    UniProtKB/TrEMBL
    H3BK13
    Conserved Domains (2) summary
    cd00086
    Location:268340
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
    pfam04814
    Location:25227
    HNF-1_N; Hepatocyte nuclear factor 1 (HNF-1), N-terminus
  7. XM_030247765.2XP_030103625.1  homeobox-containing protein 1 isoform X2

    UniProtKB/TrEMBL
    H3BKF8
    Related
    ENSMUSP00000135372.3, ENSMUST00000177326.8
    Conserved Domains (2) summary
    cd00086
    Location:268340
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
    pfam04814
    Location:25227
    HNF-1_N; Hepatocyte nuclear factor 1 (HNF-1), N-terminus
  8. XM_030247766.2XP_030103626.1  homeobox-containing protein 1 isoform X6

    UniProtKB/TrEMBL
    H3BJ31, H3BK67
    Related
    ENSMUSP00000135272.2, ENSMUST00000175744.8
    Conserved Domains (2) summary
    cd00086
    Location:268340
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
    pfam04814
    Location:25227
    HNF-1_N; Hepatocyte nuclear factor 1 (HNF-1), N-terminus
  9. XM_011245037.4XP_011243339.1  homeobox-containing protein 1 isoform X10

    UniProtKB/TrEMBL
    H3BK13
    Related
    ENSMUSP00000135657.3, ENSMUST00000175905.8
    Conserved Domains (2) summary
    cd00086
    Location:268340
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
    pfam04814
    Location:25227
    HNF-1_N; Hepatocyte nuclear factor 1 (HNF-1), N-terminus
  10. XM_011245034.4XP_011243336.1  homeobox-containing protein 1 isoform X7

    See identical proteins and their annotated locations for XP_011243336.1

    UniProtKB/TrEMBL
    H3BK13
    Conserved Domains (2) summary
    cd00086
    Location:268340
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
    pfam04814
    Location:25227
    HNF-1_N; Hepatocyte nuclear factor 1 (HNF-1), N-terminus
  11. XM_006518882.5XP_006518945.1  homeobox-containing protein 1 isoform X1

    UniProtKB/TrEMBL
    H3BKF8
    Conserved Domains (2) summary
    cd00086
    Location:268340
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
    pfam04814
    Location:25227
    HNF-1_N; Hepatocyte nuclear factor 1 (HNF-1), N-terminus
  12. XM_011245033.4XP_011243335.1  homeobox-containing protein 1 isoform X5

    See identical proteins and their annotated locations for XP_011243335.1

    UniProtKB/TrEMBL
    H3BJ31
    Conserved Domains (2) summary
    cd00086
    Location:268340
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
    pfam04814
    Location:25227
    HNF-1_N; Hepatocyte nuclear factor 1 (HNF-1), N-terminus
  13. XM_036158568.1XP_036014461.1  homeobox-containing protein 1 isoform X8

    UniProtKB/TrEMBL
    H3BK13
    Conserved Domains (2) summary
    cd00086
    Location:268340
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
    pfam04814
    Location:25227
    HNF-1_N; Hepatocyte nuclear factor 1 (HNF-1), N-terminus

RNA

  1. XR_004938387.1 RNA Sequence

  2. XR_004938386.1 RNA Sequence