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Xkr6 X-linked Kx blood group related 6 [ Mus musculus (house mouse) ]

Gene ID: 219149, updated on 27-Nov-2024

Summary

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Official Symbol
Xkr6provided by MGI
Official Full Name
X-linked Kx blood group related 6provided by MGI
Primary source
MGI:MGI:2447765
See related
Ensembl:ENSMUSG00000035067 AllianceGenome:MGI:2447765
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Xrg6; 2700008G24Rik
Summary
Predicted to be involved in apoptotic process involved in development; engulfment of apoptotic cell; and phosphatidylserine exposure on apoptotic cell surface. Is active in plasma membrane. Is expressed in nervous system. Orthologous to human XKR6 (XK related 6). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in adrenal adult (RPKM 2.4), cerebellum adult (RPKM 2.0) and 17 other tissues See more
Orthologs
human all
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Genomic context

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See Xkr6 in Genome Data Viewer
Location:
14 D1; 14 33.34 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (63841608..64084451)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (63606530..63845706)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_36926 Neighboring gene predicted gene 17232 Neighboring gene STARR-positive B cell enhancer ABC_E8564 Neighboring gene L-threonine dehydrogenase Neighboring gene myotubularin related protein 9 Neighboring gene VISTA enhancer mm1542 Neighboring gene predicted gene 15918 Neighboring gene STARR-seq mESC enhancer starr_36930 Neighboring gene STARR-seq mESC enhancer starr_36931 Neighboring gene predicted gene, 38524 Neighboring gene microRNA 598 Neighboring gene predicted gene, 36218 Neighboring gene STARR-seq mESC enhancer starr_36932 Neighboring gene predicted gene, 41175 Neighboring gene PIN2/TERF1 interacting, telomerase inhibitor 1 Neighboring gene SRY (sex determining region Y)-box 7

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Exposure of phosphatidylserine by Xk-related protein family members during apoptosis. Suzuki J, et al. J Biol Chem, 2014 Oct 31. PMID 25231987, Free PMC Article
  2. Viral Infection-Induced Differential Expression of LncRNAs Associated with Collagen in Mouse Placentas and Amniotic Sacs. Pan J, et al. Am J Reprod Immunol, 2015 Sep. PMID 26073538
  3. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808
  4. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
  5. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 

General gene information

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Markers

Homology

Clone Names

  • MGC37452

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in apoptotic process involved in development IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in engulfment of apoptotic cell IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phosphatidylserine exposure on apoptotic cell surface IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
XK-related protein 6
Names
X Kell blood group precursor related family member 6 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_173393.2 → NP_775569.2  XK-related protein 6

    See identical proteins and their annotated locations for NP_775569.2

    Status: VALIDATED

    Source sequence(s)
    AC118607, AC120788, AY534252
    Consensus CDS
    CCDS27204.2
    UniProtKB/Swiss-Prot
    E9Q6C8, G3X9Y8, Q5GH65, Q8R1I8
    Related
    ENSMUSP00000113708.3, ENSMUST00000119973.3
    Conserved Domains (1) summary
    pfam09815
    Location:131 → 497
    XK-related; XK-related protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    63841608..64084451
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036158567.1 → XP_036014460.1  XK-related protein 6 isoform X1

    Conserved Domains (1) summary
    pfam09815
    Location:127 → 418
    XK-related; XK-related protein

  2. XM_006518881.5 → XP_006518944.1  XK-related protein 6 isoform X4

    See identical proteins and their annotated locations for XP_006518944.1

    UniProtKB/Swiss-Prot
    E9Q6C8
    Related
    ENSMUSP00000112691.3, ENSMUST00000120820.3
    Conserved Domains (1) summary
    pfam09815
    Location:1 → 241
    XK-related; XK-related protein

  3. XM_017315977.3 → XP_017171466.1  XK-related protein 6 isoform X2

    Conserved Domains (1) summary
    pfam09815
    Location:33 → 280
    XK-related; XK-related protein

  4. XM_006518880.5 → XP_006518943.1  XK-related protein 6 isoform X3

    Conserved Domains (1) summary
    pfam09815
    Location:26 → 270
    XK-related; XK-related protein
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
E9Q6C8.1 GenPept UniProtKB/Swiss-Prot:E9Q6C8

Gene LinkOut

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