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Mtmr6 myotubularin related protein 6 [ Mus musculus (house mouse) ]

Gene ID: 219135, updated on 24-Jan-2023

Summary

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Official Symbol
Mtmr6provided by MGI
Official Full Name
myotubularin related protein 6provided by MGI
Primary source
MGI:MGI:2145637
See related
Ensembl:ENSMUSG00000021987 AllianceGenome:MGI:2145637
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gm38641; 4022440C11Rik
Summary
Predicted to enable phosphatidylinositol-3,5-bisphosphate phosphatase activity and phosphatidylinositol-3-phosphatase activity. Predicted to be involved in phosphatidylinositol dephosphorylation. Predicted to act upstream of or within endocytosis and lipid metabolic process. Predicted to be located in cell projection; endoplasmic reticulum; and plasma membrane. Predicted to be active in cytoplasm; membrane; and nuclear envelope. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; integumental system; and sensory organ. Orthologous to human MTMR6 (myotubularin related protein 6). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis adult (RPKM 32.5), cerebellum adult (RPKM 18.2) and 27 other tissues See more
Orthologs
human all
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Genomic context

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See Mtmr6 in Genome Data Viewer
Location:
14; 14 D1
Exon count:
20
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (60502576..60539820)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (60265180..60302371)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC108168164 Neighboring gene nucleoporin 58 Neighboring gene microRNA 719 Neighboring gene predicted gene, 34874 Neighboring gene APC membrane recruitment 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Phosphatidylinositol 3-phosphatase myotubularin-related protein 6 (MTMR6) is regulated by small GTPase Rab1B in the early secretory and autophagic pathways. Mochizuki Y, et al. J Biol Chem, 2013 Jan 11. PMID 23188820, Free PMC Article
  2. Sequential breakdown of 3-phosphorylated phosphoinositides is essential for the completion of macropinocytosis. Maekawa M, et al. Proc Natl Acad Sci U S A, 2014 Mar 18. PMID 24591580, Free PMC Article
  3. Characterization of myotubularin-related protein 7 and its binding partner, myotubularin-related protein 9. Mochizuki Y, et al. Proc Natl Acad Sci U S A, 2003 Aug 19. PMID 12890864, Free PMC Article
  4. Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method. Piao Y, et al. Genome Res, 2001 Sep. PMID 11544199, Free PMC Article
  5. BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING). Motani K, et al. J Biol Chem, 2020 Aug 7. PMID 32554809, Free PMC Article

See all (22) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC27983

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphatidylinositol phosphate phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphatidylinositol-3,5-bisphosphate phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
enables phosphatidylinositol-3,5-bisphosphate phosphatase activity ISO
Inferred from Sequence Orthology
more info
  
enables phosphatidylinositol-3-phosphate phosphatase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in dephosphorylation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within endocytosis IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in phosphatidylinositol dephosphorylation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in nuclear envelope IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
located_in nuclear envelope ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
myotubularin-related protein 6
Names
phosphatidylinositol-3,5-bisphosphate 3-phosphatase
phosphatidylinositol-3-phosphate phosphatase
NP_659092.1
XP_006518928.1
XP_017171460.1
XP_017171461.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001401198.1 → NP_001388127.1  myotubularin-related protein 6 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC166113

  2. NM_001401199.1 → NP_001388128.1  myotubularin-related protein 6 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC166113

  3. NM_001401200.1 → NP_001388129.1  myotubularin-related protein 6 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC166113

  4. NM_144843.5 → NP_659092.1  myotubularin-related protein 6 isoform 1

    See identical proteins and their annotated locations for NP_659092.1

    Status: VALIDATED

    Source sequence(s)
    AC166113
    Consensus CDS
    CCDS27176.1
    UniProtKB/Swiss-Prot
    L8AZD2, Q8VE11
    Related
    ENSMUSP00000022563.8, ENSMUST00000022563.9
    Conserved Domains (2) summary
    cd13343
    Location:1 → 101
    PH-GRAM_MTMR6; Myotubularian (MTM) related (MTMR) 6 protein Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain
    pfam06602
    Location:107 → 444
    Myotub-related; Myotubularin-like phosphatase domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    60502576..60539820
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

  2. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    60488923..60502057
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006518865.5 → XP_006518928.1  myotubularin-related protein 6 isoform X3

    Conserved Domains (2) summary
    cl17171
    Location:2 → 95
    PH-like; Pleckstrin homology-like domain
    cl28904
    Location:124 → 425
    PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

  2. XM_017315972.3 → XP_017171461.1  myotubularin-related protein 6 isoform X2

    Conserved Domains (2) summary
    cl17171
    Location:2 → 95
    PH-like; Pleckstrin homology-like domain
    cl28904
    Location:124 → 463
    PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

  3. XM_017315971.3 → XP_017171460.1  myotubularin-related protein 6 isoform X1

    UniProtKB/TrEMBL
    L8AZD2
    Related
    ENSMUSP00000153403.2, ENSMUST00000224366.2
    Conserved Domains (2) summary
    cd13343
    Location:1 → 101
    PH-GRAM_MTMR6; Myotubularian (MTM) related (MTMR) 6 protein Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain
    cl28904
    Location:130 → 469
    PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8VE11.1 GenPept UniProtKB/Swiss-Prot:Q8VE11

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