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Otop1 otopetrin 1 [ Mus musculus (house mouse) ]

Gene ID: 21906, updated on 8-Dec-2022

Summary

Official Symbol
Otop1provided by MGI
Official Full Name
otopetrin 1provided by MGI
Primary source
MGI:MGI:2388363
See related
Ensembl:ENSMUSG00000051596 AllianceGenome:MGI:2388363
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
tlt; Otp1; A530025J20Rik
Summary
Enables proton channel activity. Involved in cellular response to insulin stimulus; negative regulation of interferon-gamma-mediated signaling pathway; and proton transmembrane transport. Acts upstream of or within detection of gravity and inner ear morphogenesis. Located in membrane. Is integral component of plasma membrane. Is expressed in several structures, including adrenal gland; inner ear; integumental system; stomach; and thymus. Orthologous to human OTOP1 (otopetrin 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in adrenal adult (RPKM 7.8), mammary gland adult (RPKM 6.4) and 8 other tissues See more
Orthologs
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Genomic context

See Otop1 in Genome Data Viewer
Location:
5 B3; 5 20.35 cM
Exon count:
6
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (38434748..38461560)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (38277404..38304217)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene Ly1 antibody reactive clone Neighboring gene transmembrane protein 128 Neighboring gene predicted gene, 34193 Neighboring gene predicted gene, 26560 Neighboring gene dopamine receptor D5

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables proton channel activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables proton channel activity IDA
Inferred from Direct Assay
more info
PubMed 
enables proton channel activity ISO
Inferred from Sequence Orthology
more info
 
enables proton channel activity TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
proton channel OTOP1
Names
tilted

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_172709.3NP_766297.2  proton channel OTOP1

    See identical proteins and their annotated locations for NP_766297.2

    Status: VALIDATED

    Source sequence(s)
    AF548337, AK040792, EH101457
    UniProtKB/Swiss-Prot
    Q80VM9, Q8BS22
    UniProtKB/TrEMBL
    A0A0R4J1J4
    Related
    ENSMUSP00000109734.6, ENSMUST00000114099.6
    Conserved Domains (1) summary
    pfam03189
    Location:131586
    Otopetrin; Otopetrin

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    38434748..38461560
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_178139.1: Suppressed sequence

    Description
    NM_178139.1: This RefSeq was temporarily suppressed because currently sufficient experimental data to support this transcript do not exist.