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Tlr4 toll-like receptor 4 [ Mus musculus (house mouse) ]

Gene ID: 21898, updated on 15-Jan-2019

Summary

Official Symbol
Tlr4provided by MGI
Official Full Name
toll-like receptor 4provided by MGI
Primary source
MGI:MGI:96824
See related
Ensembl:ENSMUSG00000039005
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Lps; Ly87; Ran/M1; Rasl2-8
Summary
This gene belongs to the evolutionarily-conserved Toll-like receptor family, whose members are type-1 transmembrane proteins that are involved in innate immunity. Toll-like receptors are characterized by an extracellular leucine-rich repeat domain that functions in ligand recognition and an intracellular toll/interleukin-1 receptor-like domain that is crucial for signal transduction. The receptor encoded by this gene mediates the innate immune response to bacterial lipopolysaccharide, a major component of the outer membrane of Gram-negative bacteria, through synthesis of pro-inflammatory cytokines and chemokines. In addition, this protein can recognize other pathogens from Gram-negative and Gram-positive bacteria as well as viral components. Mice deficient in this gene display a number of immune response-related phenotypes including hyporesponsiveness to bacterial lipopolysaccharide and increased levels of respiratory syncytial virus compared to controls. [provided by RefSeq, Sep 2015]
Expression
Broad expression in bladder adult (RPKM 2.0), subcutaneous fat pad adult (RPKM 1.2) and 20 other tissues See more
Orthologs

Genomic context

See Tlr4 in Genome Data Viewer
Location:
4 C1; 4 34.66 cM
Exon count:
3
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 4 NC_000070.6 (66827551..66846581)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 4 NC_000070.5 (66488845..66503831)

Chromosome 4 - NC_000070.6Genomic Context describing neighboring genes Neighboring gene astrotactin 2 Neighboring gene predicted gene, 31533 Neighboring gene predicted gene 11220 Neighboring gene high mobility group box 1, related sequence 18 Neighboring gene ribosomal protein S2 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from BioSystems

  • Activated TLR4 signalling, organism-specific biosystem (from REACTOME)
    Activated TLR4 signalling, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Amoebiasis, organism-specific biosystem (from KEGG)
    Amoebiasis, organism-specific biosystemEntamoeba histolytica, an extracellular protozoan parasite is a human pathogen that invades the intestinal epithelium. Infection occurs on ingestion of contaminated water and food. The pathogenesis o...
  • Amoebiasis, conserved biosystem (from KEGG)
    Amoebiasis, conserved biosystemEntamoeba histolytica, an extracellular protozoan parasite is a human pathogen that invades the intestinal epithelium. Infection occurs on ingestion of contaminated water and food. The pathogenesis o...
  • ApoE and miR-146 in inflammation and atherosclerosis, organism-specific biosystem (from WikiPathways)
    ApoE and miR-146 in inflammation and atherosclerosis, organism-specific biosystemApolipoprotein E (ApoE) enhances purine-rich PU-box-binding protein 1 (PU.1)-dependent miR-146a transcription to suppress nuclear factor-?B (NF-?B)-driven monocyte and macrophage activation and there...
  • Chagas disease (American trypanosomiasis), organism-specific biosystem (from KEGG)
    Chagas disease (American trypanosomiasis), organism-specific biosystemTrypanosoma cruzi is an intracellular protozoan parasite that causes Chagas disease. The parasite life cycle involves hematophagous reduviid bugs as vectors. Once parasites enter the host body, they ...
  • Chagas disease (American trypanosomiasis), conserved biosystem (from KEGG)
    Chagas disease (American trypanosomiasis), conserved biosystemTrypanosoma cruzi is an intracellular protozoan parasite that causes Chagas disease. The parasite life cycle involves hematophagous reduviid bugs as vectors. Once parasites enter the host body, they ...
  • HIF-1 signaling pathway, organism-specific biosystem (from KEGG)
    HIF-1 signaling pathway, organism-specific biosystemHypoxia-inducible factor 1 (HIF-1) is a transcription factor that functions as a master regulator of oxygen homeostasis. It consists of two subunits: an inducibly-expressed HIF-1alpha subunit and a c...
  • Hepatitis B, organism-specific biosystem (from KEGG)
    Hepatitis B, organism-specific biosystemHepatitis B virus (HBV) is an enveloped virus and contains a partially double-stranded relaxed circular DNA (RC-DNA) genome. After entry into hepatocytes, HBV RC-DNA is transported to the nucleus and...
  • Immune System, organism-specific biosystem (from REACTOME)
    Immune System, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Inflammatory bowel disease (IBD), organism-specific biosystem (from KEGG)
    Inflammatory bowel disease (IBD), organism-specific biosystemInflammatory bowel disease (IBD), which includes Crohn disease (CD) and ulcerative colitis (UC), is characterized by chronic inflammation of the gastrointestinal tract due to environmental and geneti...
  • Inflammatory bowel disease (IBD), conserved biosystem (from KEGG)
    Inflammatory bowel disease (IBD), conserved biosystemInflammatory bowel disease (IBD), which includes Crohn disease (CD) and ulcerative colitis (UC), is characterized by chronic inflammation of the gastrointestinal tract due to environmental and geneti...
  • Influenza A, organism-specific biosystem (from KEGG)
    Influenza A, organism-specific biosystemInfluenza is a contagious respiratory disease caused by influenza virus infection. Influenza A virus is responsible for both annual seasonal epidemics and periodic worldwide pandemics. Novel strains ...
  • Influenza A, conserved biosystem (from KEGG)
    Influenza A, conserved biosystemInfluenza is a contagious respiratory disease caused by influenza virus infection. Influenza A virus is responsible for both annual seasonal epidemics and periodic worldwide pandemics. Novel strains ...
  • Innate Immune System, organism-specific biosystem (from REACTOME)
    Innate Immune System, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Legionellosis, organism-specific biosystem (from KEGG)
    Legionellosis, organism-specific biosystemLegionellosis is a potentially fatal infectious disease caused by the bacterium Legionella pneumophila and other legionella species. Two distinct clinical and epidemiological syndromes are associated...
  • Legionellosis, conserved biosystem (from KEGG)
    Legionellosis, conserved biosystemLegionellosis is a potentially fatal infectious disease caused by the bacterium Legionella pneumophila and other legionella species. Two distinct clinical and epidemiological syndromes are associated...
  • Leishmaniasis, organism-specific biosystem (from KEGG)
    Leishmaniasis, organism-specific biosystemLeishmania is an intracellular protozoan parasite of macrophages that causes visceral, mucosal, and cutaneous diseases. The parasite is transmitted to humans by sandflies, where they survive and prol...
  • Leishmaniasis, conserved biosystem (from KEGG)
    Leishmaniasis, conserved biosystemLeishmania is an intracellular protozoan parasite of macrophages that causes visceral, mucosal, and cutaneous diseases. The parasite is transmitted to humans by sandflies, where they survive and prol...
  • Malaria, organism-specific biosystem (from KEGG)
    Malaria, organism-specific biosystemPlasmodium protozoa are parasites that account for malaria infection. Sporozoite forms of the parasite are injected by mosquito bites under the skin and are carried to the liver where they develop in...
  • Malaria, conserved biosystem (from KEGG)
    Malaria, conserved biosystemPlasmodium protozoa are parasites that account for malaria infection. Sporozoite forms of the parasite are injected by mosquito bites under the skin and are carried to the liver where they develop in...
  • Measles, organism-specific biosystem (from KEGG)
    Measles, organism-specific biosystemMeasles virus (MV) is highly contagious virus that leads infant death worldwide. Humans are the unique natural reservoir for this virus. It causes severe immunosuppression favouring secondary bacteri...
  • Measles, conserved biosystem (from KEGG)
    Measles, conserved biosystemMeasles virus (MV) is highly contagious virus that leads infant death worldwide. Humans are the unique natural reservoir for this virus. It causes severe immunosuppression favouring secondary bacteri...
  • MyD88-independent TLR3/TLR4 cascade, organism-specific biosystem (from REACTOME)
    MyD88-independent TLR3/TLR4 cascade, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • NF-kappa B signaling pathway, organism-specific biosystem (from KEGG)
    NF-kappa B signaling pathway, organism-specific biosystemNuclear factor-kappa B (NF-kappa B) is the generic name of a family of transcription factors that function as dimers and regulate genes involved in immunity, inflammation and cell survival. There are...
  • NF-kappa B signaling pathway, conserved biosystem (from KEGG)
    NF-kappa B signaling pathway, conserved biosystemNuclear factor-kappa B (NF-kappa B) is the generic name of a family of transcription factors that function as dimers and regulate genes involved in immunity, inflammation and cell survival. There are...
  • NOD-like receptor signaling pathway, organism-specific biosystem (from KEGG)
    NOD-like receptor signaling pathway, organism-specific biosystemSpecific families of pattern recognition receptors are responsible for detecting various pathogens and generating innate immune responses. The intracellular NOD-like receptor (NLR) family contains mo...
  • NOD-like receptor signaling pathway, conserved biosystem (from KEGG)
    NOD-like receptor signaling pathway, conserved biosystemSpecific families of pattern recognition receptors are responsible for detecting various pathogens and generating innate immune responses. The intracellular NOD-like receptor (NLR) family contains mo...
  • PI3K-Akt signaling pathway, organism-specific biosystem (from KEGG)
    PI3K-Akt signaling pathway, organism-specific biosystemThe phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, tra...
  • PI3K-Akt signaling pathway, conserved biosystem (from KEGG)
    PI3K-Akt signaling pathway, conserved biosystemThe phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, tra...
  • Pertussis, organism-specific biosystem (from KEGG)
    Pertussis, organism-specific biosystemPertussis, also known as whooping cough, is an acute respiratory infectious disease caused by a bacteria called Bordetella Pertussis. The characteristic symptoms are paroxysmal cough, inspiratory whe...
  • Pertussis, conserved biosystem (from KEGG)
    Pertussis, conserved biosystemPertussis, also known as whooping cough, is an acute respiratory infectious disease caused by a bacteria called Bordetella Pertussis. The characteristic symptoms are paroxysmal cough, inspiratory whe...
  • Phagosome, organism-specific biosystem (from KEGG)
    Phagosome, organism-specific biosystemPhagocytosis is the process of taking in relatively large particles by a cell, and is a central mechanism in the tissue remodeling, inflammation, and defense against infectious agents. A phagosome is...
  • Phagosome, conserved biosystem (from KEGG)
    Phagosome, conserved biosystemPhagocytosis is the process of taking in relatively large particles by a cell, and is a central mechanism in the tissue remodeling, inflammation, and defense against infectious agents. A phagosome is...
  • Primary Focal Segmental Glomerulosclerosis FSGS, organism-specific biosystem (from WikiPathways)
    Primary Focal Segmental Glomerulosclerosis FSGS, organism-specific biosystemPrimary or idiopathic focal segmental glomerulosclerosis (FSGS) a cause of nephrotic syndrome in children and adolescents, as well as an important cause of end stage renal disease in adults. FSGS is ...
  • Proteoglycans in cancer, organism-specific biosystem (from KEGG)
    Proteoglycans in cancer, organism-specific biosystemMany proteoglycans (PGs) in the tumor microenvironment have been shown to be key macromolecules that contribute to biology of various types of cancer including proliferation, adhesion, angiogenesis a...
  • Proteoglycans in cancer, conserved biosystem (from KEGG)
    Proteoglycans in cancer, conserved biosystemMany proteoglycans (PGs) in the tumor microenvironment have been shown to be key macromolecules that contribute to biology of various types of cancer including proliferation, adhesion, angiogenesis a...
  • Regulation of TLR by endogenous ligand, organism-specific biosystem (from REACTOME)
    Regulation of TLR by endogenous ligand, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Rheumatoid arthritis, organism-specific biosystem (from KEGG)
    Rheumatoid arthritis, organism-specific biosystemRheumatoid arthritis (RA) is a chronic autoimmune joint disease where persistent inflammation affects bone remodeling leading to progressive bone destruction. In RA, abnormal activation of the immune...
  • Rheumatoid arthritis, conserved biosystem (from KEGG)
    Rheumatoid arthritis, conserved biosystemRheumatoid arthritis (RA) is a chronic autoimmune joint disease where persistent inflammation affects bone remodeling leading to progressive bone destruction. In RA, abnormal activation of the immune...
  • Salmonella infection, organism-specific biosystem (from KEGG)
    Salmonella infection, organism-specific biosystemSalmonella infection usually presents as a self-limiting gastroenteritis or the more severe typhoid fever and bacteremia. The common disease-causing Salmonella species in human is a single species, S...
  • Salmonella infection, conserved biosystem (from KEGG)
    Salmonella infection, conserved biosystemSalmonella infection usually presents as a self-limiting gastroenteritis or the more severe typhoid fever and bacteremia. The common disease-causing Salmonella species in human is a single species, S...
  • Spinal Cord Injury, organism-specific biosystem (from WikiPathways)
    Spinal Cord Injury, organism-specific biosystemThis pathway provides an overview of cell types, therapeutic targets, drugs, new proposed targets and pathways implicated in spinal cord injury. Spinal cord injury is a complex multi-step process tha...
  • TLR4 (Toll-like receptor 4) signaling pathway, organism-specific biosystem (from LIPID MAPS)
    TLR4 (Toll-like receptor 4) signaling pathway, organism-specific biosystem
    TLR4 (Toll-like receptor 4) signaling pathway
  • Toll Like Receptor 3 (TLR3) Cascade, organism-specific biosystem (from REACTOME)
    Toll Like Receptor 3 (TLR3) Cascade, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Toll Like Receptor 4 (TLR4) Cascade, organism-specific biosystem (from REACTOME)
    Toll Like Receptor 4 (TLR4) Cascade, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Toll Like Receptor signaling, organism-specific biosystem (from WikiPathways)
    Toll Like Receptor signaling, organism-specific biosystemToll-like receptors (TLRs) are a class of proteins that play a key role in the innate immune system. They are single, membrane-spanning, non-catalytic receptors usually expressed in sentinel cells su...
  • Toll-Like Receptors Cascades, organism-specific biosystem (from REACTOME)
    Toll-Like Receptors Cascades, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Toll-like receptor signaling, organism-specific biosystem (from KEGG)
    Toll-like receptor signaling, organism-specific biosystemFunctional set; Cellular processes; Cell signaling
  • Toll-like receptor signaling, conserved biosystem (from KEGG)
    Toll-like receptor signaling, conserved biosystemFunctional set; Cellular processes; Cell signaling
  • Toll-like receptor signaling pathway, organism-specific biosystem (from KEGG)
    Toll-like receptor signaling pathway, organism-specific biosystemSpecific families of pattern recognition receptors are responsible for detecting microbial pathogens and generating innate immune responses. Toll-like receptors (TLRs) are membrane-bound receptors id...
  • Toll-like receptor signaling pathway, conserved biosystem (from KEGG)
    Toll-like receptor signaling pathway, conserved biosystemSpecific families of pattern recognition receptors are responsible for detecting microbial pathogens and generating innate immune responses. Toll-like receptors (TLRs) are membrane-bound receptors id...
  • Toxoplasmosis, organism-specific biosystem (from KEGG)
    Toxoplasmosis, organism-specific biosystemToxoplasma gondii is an obligate intracellular parasite that is prevalent worldwide. The tachyzoite form acquired by oral ingestion downmodulates proinflammatory signaling pathways via various mechan...
  • Toxoplasmosis, conserved biosystem (from KEGG)
    Toxoplasmosis, conserved biosystemToxoplasma gondii is an obligate intracellular parasite that is prevalent worldwide. The tachyzoite form acquired by oral ingestion downmodulates proinflammatory signaling pathways via various mechan...
  • Tuberculosis, organism-specific biosystem (from KEGG)
    Tuberculosis, organism-specific biosystemTuberculosis, or TB, is an infectious disease caused by Mycobacterium tuberculosis. One third of the world's population is thought to be infected with TB. About 90% of those infected result in latent...
  • Tuberculosis, conserved biosystem (from KEGG)
    Tuberculosis, conserved biosystemTuberculosis, or TB, is an infectious disease caused by Mycobacterium tuberculosis. One third of the world's population is thought to be infected with TB. About 90% of those infected result in latent...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
identical protein binding ISO
Inferred from Sequence Orthology
more info
 
lipopolysaccharide binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
lipopolysaccharide binding ISO
Inferred from Sequence Orthology
more info
 
lipopolysaccharide receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
lipopolysaccharide receptor activity ISO
Inferred from Sequence Orthology
more info
 
phosphatidylinositol 3-kinase binding ISO
Inferred from Sequence Orthology
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein heterodimerization activity ISO
Inferred from Sequence Orthology
more info
 
signaling receptor binding ISO
Inferred from Sequence Orthology
more info
 
transmembrane signaling receptor activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
B cell proliferation involved in immune response IMP
Inferred from Mutant Phenotype
more info
PubMed 
I-kappaB phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
I-kappaB phosphorylation ISO
Inferred from Sequence Orthology
more info
 
MyD88-dependent toll-like receptor signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
TRIF-dependent toll-like receptor signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
activation of MAPK activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
activation of NF-kappaB-inducing kinase activity NAS
Non-traceable Author Statement
more info
PubMed 
activation of innate immune response IMP
Inferred from Mutant Phenotype
more info
PubMed 
astrocyte development IMP
Inferred from Mutant Phenotype
more info
PubMed 
cellular response to amyloid-beta ISO
Inferred from Sequence Orthology
more info
 
cellular response to interferon-gamma ISO
Inferred from Sequence Orthology
more info
 
cellular response to lipopolysaccharide IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to lipopolysaccharide IMP
Inferred from Mutant Phenotype
more info
PubMed 
cellular response to lipopolysaccharide ISO
Inferred from Sequence Orthology
more info
 
cellular response to lipoteichoic acid IMP
Inferred from Mutant Phenotype
more info
PubMed 
cellular response to oxidised low-density lipoprotein particle stimulus IGI
Inferred from Genetic Interaction
more info
PubMed 
defense response to Gram-negative bacterium IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
defense response to Gram-negative bacterium IMP
Inferred from Mutant Phenotype
more info
PubMed 
detection of lipopolysaccharide ISO
Inferred from Sequence Orthology
more info
 
detection of lipopolysaccharide TAS
Traceable Author Statement
more info
PubMed 
detection of mechanical stimulus involved in sensory perception of pain ISO
Inferred from Sequence Orthology
more info
 
detection of temperature stimulus involved in sensory perception of pain ISO
Inferred from Sequence Orthology
more info
 
immune system process IEA
Inferred from Electronic Annotation
more info
 
inflammatory response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
innate immune response TAS
Traceable Author Statement
more info
PubMed 
innate immune response-activating signal transduction ISO
Inferred from Sequence Orthology
more info
 
interferon-gamma production IGI
Inferred from Genetic Interaction
more info
PubMed 
interleukin-1 beta secretion IDA
Inferred from Direct Assay
more info
PubMed 
intestinal epithelial structure maintenance IMP
Inferred from Mutant Phenotype
more info
PubMed 
leukotriene metabolic process ISO
Inferred from Sequence Orthology
more info
 
lipopolysaccharide-mediated signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
lipopolysaccharide-mediated signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
lipopolysaccharide-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
PubMed 
NOT lipopolysaccharide-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
PubMed 
macrophage activation ISO
Inferred from Sequence Orthology
more info
 
macrophage activation ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
mast cell activation NAS
Non-traceable Author Statement
more info
PubMed 
microglial cell activation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of ERK1 and ERK2 cascade IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of cold-induced thermogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of interferon-gamma production IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of interleukin-17 production IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of interleukin-23 production IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of interleukin-6 production IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of tumor necrosis factor production IMP
Inferred from Mutant Phenotype
more info
PubMed 
nitric oxide production involved in inflammatory response IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of B cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of DNA binding ISO
Inferred from Sequence Orthology
more info
 
positive regulation of DNA-binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
positive regulation of ERK1 and ERK2 cascade IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of I-kappaB kinase/NF-kappaB signaling IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of JNK cascade IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of JNK cascade IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of MHC class II biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of NF-kappaB transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
positive regulation of NIK/NF-kappaB signaling ISO
Inferred from Sequence Orthology
more info
 
positive regulation of NLRP3 inflammasome complex assembly IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cellular response to macrophage colony-stimulating factor stimulus ISO
Inferred from Sequence Orthology
more info
 
positive regulation of chemokine production IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of chemokine production ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cytokine production involved in inflammatory response IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of gene expression IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
positive regulation of inflammatory response IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of inflammatory response ISO
Inferred from Sequence Orthology
more info
 
positive regulation of interferon-alpha production IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of interferon-beta biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of interferon-beta production IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of interferon-gamma production IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of interleukin-1 beta secretion ISO
Inferred from Sequence Orthology
more info
 
positive regulation of interleukin-1 biosynthetic process NAS
Non-traceable Author Statement
more info
PubMed 
positive regulation of interleukin-1 production IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of interleukin-10 production IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of interleukin-12 biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
positive regulation of interleukin-12 production IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of interleukin-13 biosynthetic process NAS
Non-traceable Author Statement
more info
PubMed 
positive regulation of interleukin-6 biosynthetic process NAS
Non-traceable Author Statement
more info
PubMed 
positive regulation of interleukin-6 production IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of interleukin-6 production IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of interleukin-6 production ISO
Inferred from Sequence Orthology
more info
 
positive regulation of interleukin-6 production NAS
Non-traceable Author Statement
more info
PubMed 
positive regulation of interleukin-8 biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
positive regulation of interleukin-8 production ISO
Inferred from Sequence Orthology
more info
 
positive regulation of lymphocyte proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of macrophage activation IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of macrophage cytokine production IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of nitric oxide biosynthetic process IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of nitric oxide biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of nitric-oxide synthase biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of oxidative stress-induced neuron death IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of peptidyl-tyrosine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of platelet activation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of reactive oxygen species biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of stress-activated MAPK cascade IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of tumor necrosis factor biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
positive regulation of tumor necrosis factor production IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of tumor necrosis factor production IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of cytokine secretion IEA
Inferred from Electronic Annotation
more info
 
regulation of dendritic cell cytokine production IDA
Inferred from Direct Assay
more info
PubMed 
regulation of inflammatory response IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of sensory perception of pain ISO
Inferred from Sequence Orthology
more info
 
regulation of tumor necrosis factor secretion ISO
Inferred from Sequence Orthology
more info
 
response to bacterium IMP
Inferred from Mutant Phenotype
more info
PubMed 
response to ethanol ISO
Inferred from Sequence Orthology
more info
 
response to fatty acid ISO
Inferred from Sequence Orthology
more info
 
response to lipopolysaccharide IGI
Inferred from Genetic Interaction
more info
PubMed 
response to lipopolysaccharide IMP
Inferred from Mutant Phenotype
more info
PubMed 
response to lipopolysaccharide ISO
Inferred from Sequence Orthology
more info
 
response to oxidative stress ISO
Inferred from Sequence Orthology
more info
 
signal transduction IEA
Inferred from Electronic Annotation
more info
 
toll-like receptor 4 signaling pathway IEA
Inferred from Electronic Annotation
more info
 
toll-like receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
toll-like receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
cell surface ISO
Inferred from Sequence Orthology
more info
 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
endosome IEA
Inferred from Electronic Annotation
more info
 
external side of plasma membrane ISO
Inferred from Sequence Orthology
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
integral component of plasma membrane ISO
Inferred from Sequence Orthology
more info
 
intrinsic component of plasma membrane ISO
Inferred from Sequence Orthology
more info
 
lipopolysaccharide receptor complex ISO
Inferred from Sequence Orthology
more info
 
membrane IEA
Inferred from Electronic Annotation
more info
 
colocalizes_with membrane raft ISO
Inferred from Sequence Orthology
more info
 
perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane ISO
Inferred from Sequence Orthology
more info
 
receptor complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
toll-like receptor 4
Names
Toll like receptor 4
lipopolysaccharide response

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_021297.3NP_067272.1  toll-like receptor 4 precursor

    See identical proteins and their annotated locations for NP_067272.1

    Status: REVIEWED

    Source sequence(s)
    AI450864, AK030348, BX514079, BX649609, CD544295, JX878359
    Consensus CDS
    CCDS18271.1
    UniProtKB/Swiss-Prot
    Q9QUK6
    UniProtKB/TrEMBL
    L0CL36
    Related
    ENSMUSP00000045770.5, ENSMUST00000048096.11
    Conserved Domains (4) summary
    smart00255
    Location:672813
    TIR; Toll - interleukin 1 - resistance
    cd00116
    Location:369555
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:5878
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:53113
    LRR_8; Leucine rich repeat

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000070.6 Reference GRCm38.p4 C57BL/6J

    Range
    66827551..66846581
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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