Dlgap5 DLG associated protein 5 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Dlgap5provided by MGI
Official Full Name: DLG associated protein 5provided by MGI
Primary source: MGI:MGI:2183453
See related: Ensembl:ENSMUSG00000037544 AllianceGenome:MGI:2183453
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Dlg7; Hurp; Dap-5; mKIAA0008
Summary: Predicted to enable microtubule binding activity. Predicted to be involved in several processes, including centrosome localization; kinetochore assembly; and mitotic spindle organization. Predicted to be located in centriolar satellite; cytosol; and mitochondrion. Predicted to be active in cytoplasm; nucleus; and spindle pole centrosome. Is expressed in hemolymphoid system gland; intestine; liver; and reproductive system. Orthologous to human DLGAP5 (DLG associated protein 5). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in liver E14 (RPKM 20.5), liver E14.5 (RPKM 17.2) and 10 other tissues See more
Orthologs: human all
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Genomic context

Location:: 14 C1; 14 24.6 cM

Exon count:: 19

Annotation release	Status	Assembly	Chr	Location
109	current	GRCm39 (GCF_000001635.27)	14	NC_000080.7 (47625236..47655864, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	14	NC_000080.6 (47387779..47418407, complement)

Chromosome 14 - NC_000080.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The process of bipolar spindle assembly in the presence of multiple MTOCs in female meiosis resembles the clustering of extra centrosomes during cancer cell division. HURP plays an essential role in both processes.
Title: HURP permits MTOC sorting for robust meiotic spindle bipolarity, similar to extra centrosome clustering in cancer cells.
HURP has an essential function in uterine biology
Title: Hurp deficiency in mice leads to female infertility caused by an implantation defect.
These results indicate that the HURP gene might be a potential oncogenic gene and capable of enhancing the chemosensitivity of deoxycytosine analogs in NIH3T3 cells.
Title: Enhanced transformation and chemosensitivity of NIH3T3 cells transduced with hepatoma up-regulated protein.
endogenous levels of HURP mRNA were found to be tightly regulated during cell cycle progression and in regenerating mouse liver after partial hepatectomy [HURP]
Title: Identification of a novel cell cycle regulated gene, HURP, overexpressed in human hepatocellular carcinoma.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH126167 (e-PCR)
- UniSTS:162877

C86398 (e-PCR)
- UniSTS:180640

Homology

Homologs of the Dlgap5 gene: The Dlgap5 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, rat, chicken, and zebrafish.
Orthologs from Annotation Pipeline: 494 organisms have orthologs with human gene Dlgap5
Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables microtubule binding	IBA Inferred from Biological aspect of Ancestor more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within cell cycle	IEA Inferred from Electronic Annotation more info
involved_in centrosome localization	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in chromosome segregation	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in kinetochore assembly	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in mitotic spindle organization	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in regulation of mitotic cell cycle	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in signaling	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info	PubMed
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in mitotic spindle	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info
is_active_in spindle pole centrosome	IBA Inferred from Biological aspect of Ancestor more info	PubMed
located_in spindle pole centrosome	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: disks large-associated protein 5

Names: discs, large homolog 7; discs, large homolog-associated protein 5; hepatoma up-regulated protein homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_144553.2 → NP_653136.2 disks large-associated protein 5

See identical proteins and their annotated locations for NP_653136.2

Status: VALIDATED

Source sequence(s)

AB076696, AC123665, AK085882

Consensus CDS

CCDS26987.1

UniProtKB/Swiss-Prot

Q8K4R9

UniProtKB/TrEMBL

A0A0R4J0G7

Related

ENSMUSP00000040416.4, ENSMUST00000043296.10

Conserved Domains (1) summary

pfam03359
Location:397 → 543

GKAP; Guanylate-kinase-associated protein (GKAP) protein

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000080.7 Reference GRCm39 C57BL/6J

Range

47625236..47655864 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006518835.5 → XP_006518898.1 disks large-associated protein 5 isoform X3

Conserved Domains (1) summary

pfam03359
Location:399 → 543

GKAP; Guanylate-kinase-associated protein (GKAP) protein
XM_006518833.2 → XP_006518896.1 disks large-associated protein 5 isoform X1

Conserved Domains (1) summary

pfam03359
Location:387 → 531

GKAP; Guanylate-kinase-associated protein (GKAP) protein
XM_006518834.2 → XP_006518897.1 disks large-associated protein 5 isoform X2

Related

ENSMUSP00000153953.2, ENSMUST00000180299.8

Conserved Domains (1) summary

pfam03359
Location:399 → 543

GKAP; Guanylate-kinase-associated protein (GKAP) protein

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_001145949.1: Suppressed sequence

Description

NM_001145949.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein, and the transcript appears incompletely processed at its 3' end.