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Tlr1 toll-like receptor 1 [ Mus musculus (house mouse) ]

Gene ID: 21897, updated on 26-Sep-2022

Summary

Official Symbol
Tlr1provided by MGI
Official Full Name
toll-like receptor 1provided by MGI
Primary source
MGI:MGI:1341295
See related
Ensembl:ENSMUSG00000044827 AllianceGenome:MGI:1341295
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to enable several functions, including Toll-like receptor 2 binding activity; identical protein binding activity; and lipopeptide binding activity. Involved in positive regulation of interleukin-6 production and positive regulation of tumor necrosis factor production. Acts upstream of or within defense response. Predicted to be located in Golgi apparatus and membrane raft. Predicted to be part of Toll-like receptor 1-Toll-like receptor 2 protein complex. Predicted to be integral component of plasma membrane. Is expressed in cerebral cortex and telencephalon. Human ortholog(s) of this gene implicated in several diseases, including IgA glomerulonephritis; aspergillosis; leprosy; pyelonephritis; and tuberculosis. Orthologous to human TLR1 (toll like receptor 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in spleen adult (RPKM 12.1), colon adult (RPKM 6.6) and 11 other tissues See more
Orthologs
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Genomic context

See Tlr1 in Genome Data Viewer
Location:
5 C3.1; 5 33.53 cM
Exon count:
5
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (65082023..65090945, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (64924680..64933600, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 31889 Neighboring gene toll-like receptor 1 pseudogene Neighboring gene toll-like receptor 6 Neighboring gene family with sequence similarity 114, member A1 Neighboring gene microRNA 574 Neighboring gene predicted gene, 32374

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2)  1 citation
  • Endonuclease-mediated (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables Toll-like receptor 2 binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables Toll-like receptor 2 binding ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables lipopeptide binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables lipopeptide binding ISO
Inferred from Sequence Orthology
more info
 
enables signaling receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables transmembrane signaling receptor activity NAS
Non-traceable Author Statement
more info
PubMed 
enables triacyl lipopeptide binding NAS
Non-traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
involved_in MyD88-dependent toll-like receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in activation of NF-kappaB-inducing kinase activity NAS
Non-traceable Author Statement
more info
PubMed 
involved_in cell activation ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to bacterial lipopeptide IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cellular response to triacyl bacterial lipopeptide IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within cellular response to triacyl bacterial lipopeptide ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within defense response IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within detection of triacyl bacterial lipopeptide ISO
Inferred from Sequence Orthology
more info
 
involved_in detection of triacyl bacterial lipopeptide NAS
Non-traceable Author Statement
more info
PubMed 
involved_in immune response IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within immune system process IEA
Inferred from Electronic Annotation
more info
 
involved_in inflammatory response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within innate immune response IEA
Inferred from Electronic Annotation
more info
 
involved_in macrophage activation NAS
Non-traceable Author Statement
more info
PubMed 
involved_in microglial cell activation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of interleukin-6 production IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of interleukin-8 production ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of toll-like receptor 2 signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of tumor necrosis factor production IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of cytokine production IEA
Inferred from Electronic Annotation
more info
 
involved_in response to bacterial lipoprotein ISO
Inferred from Sequence Orthology
more info
 
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
 
involved_in toll-like receptor 1 signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in toll-like receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in toll-like receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
 
part_of Toll-like receptor 1-Toll-like receptor 2 protein complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of Toll-like receptor 1-Toll-like receptor 2 protein complex ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
 
located_in membrane NAS
Non-traceable Author Statement
more info
PubMed 
located_in membrane raft ISO
Inferred from Sequence Orthology
more info
 
located_in phagocytic vesicle NAS
Non-traceable Author Statement
more info
PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of receptor complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
toll-like receptor 1
Names
TIL
toll/interleukin-1 receptor-like protein
NP_001263374.1
NP_109607.1
XP_006503914.1
XP_006503916.1
XP_006503917.1
XP_006503919.1
XP_011239022.1
XP_030110223.1
XP_036020886.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001276445.1NP_001263374.1  toll-like receptor 1 precursor

    See identical proteins and their annotated locations for NP_001263374.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC161757
    Consensus CDS
    CCDS19302.1
    UniProtKB/Swiss-Prot
    Q9EPQ1, Q9EPW5
    UniProtKB/TrEMBL
    B9EJ46
    Related
    ENSMUSP00000142500.2, ENSMUST00000197315.5
    Conserved Domains (6) summary
    PRK15370
    Location:377487
    PRK15370; type III secretion system effector E3 ubiquitin transferase SlrP
    smart00082
    Location:527581
    LRRCT; Leucine rich repeat C-terminal domain
    smart00255
    Location:639782
    TIR; Toll - interleukin 1 - resistance
    COG4886
    Location:48317
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    sd00031
    Location:5073
    LRR_1; leucine-rich repeat [structural motif]
    sd00033
    Location:355376
    LRR_RI; leucine-rich repeat [structural motif]
  2. NM_030682.2NP_109607.1  toll-like receptor 1 precursor

    See identical proteins and their annotated locations for NP_109607.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the shorter transcript. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC161757, AY009154
    Consensus CDS
    CCDS19302.1
    UniProtKB/Swiss-Prot
    Q9EPQ1, Q9EPW5
    UniProtKB/TrEMBL
    B9EJ46
    Related
    ENSMUSP00000060793.5, ENSMUST00000059349.6
    Conserved Domains (6) summary
    PRK15370
    Location:377487
    PRK15370; type III secretion system effector E3 ubiquitin transferase SlrP
    smart00082
    Location:527581
    LRRCT; Leucine rich repeat C-terminal domain
    smart00255
    Location:639782
    TIR; Toll - interleukin 1 - resistance
    COG4886
    Location:48317
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    sd00031
    Location:5073
    LRR_1; leucine-rich repeat [structural motif]
    sd00033
    Location:355376
    LRR_RI; leucine-rich repeat [structural motif]

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    65082023..65090945 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006503854.2XP_006503917.1  toll-like receptor 1 isoform X1

    See identical proteins and their annotated locations for XP_006503917.1

    UniProtKB/Swiss-Prot
    Q9EPQ1, Q9EPW5
    UniProtKB/TrEMBL
    B9EJ46
    Conserved Domains (6) summary
    PRK15370
    Location:377487
    PRK15370; type III secretion system effector E3 ubiquitin transferase SlrP
    smart00082
    Location:527581
    LRRCT; Leucine rich repeat C-terminal domain
    smart00255
    Location:639782
    TIR; Toll - interleukin 1 - resistance
    COG4886
    Location:48317
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    sd00031
    Location:5073
    LRR_1; leucine-rich repeat [structural motif]
    sd00033
    Location:355376
    LRR_RI; leucine-rich repeat [structural motif]
  2. XM_006503853.3XP_006503916.1  toll-like receptor 1 isoform X1

    See identical proteins and their annotated locations for XP_006503916.1

    UniProtKB/Swiss-Prot
    Q9EPQ1, Q9EPW5
    UniProtKB/TrEMBL
    B9EJ46
    Conserved Domains (6) summary
    PRK15370
    Location:377487
    PRK15370; type III secretion system effector E3 ubiquitin transferase SlrP
    smart00082
    Location:527581
    LRRCT; Leucine rich repeat C-terminal domain
    smart00255
    Location:639782
    TIR; Toll - interleukin 1 - resistance
    COG4886
    Location:48317
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    sd00031
    Location:5073
    LRR_1; leucine-rich repeat [structural motif]
    sd00033
    Location:355376
    LRR_RI; leucine-rich repeat [structural motif]
  3. XM_030254363.2XP_030110223.1  toll-like receptor 1 isoform X1

    UniProtKB/Swiss-Prot
    Q9EPW5
    UniProtKB/TrEMBL
    B9EJ46
    Conserved Domains (6) summary
    PRK15370
    Location:377487
    PRK15370; type III secretion system effector E3 ubiquitin transferase SlrP
    smart00082
    Location:527581
    LRRCT; Leucine rich repeat C-terminal domain
    smart00255
    Location:639782
    TIR; Toll - interleukin 1 - resistance
    COG4886
    Location:48317
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    sd00031
    Location:5073
    LRR_1; leucine-rich repeat [structural motif]
    sd00033
    Location:355376
    LRR_RI; leucine-rich repeat [structural motif]
  4. XM_006503856.3XP_006503919.1  toll-like receptor 1 isoform X1

    See identical proteins and their annotated locations for XP_006503919.1

    UniProtKB/Swiss-Prot
    Q9EPQ1, Q9EPW5
    UniProtKB/TrEMBL
    B9EJ46
    Conserved Domains (6) summary
    PRK15370
    Location:377487
    PRK15370; type III secretion system effector E3 ubiquitin transferase SlrP
    smart00082
    Location:527581
    LRRCT; Leucine rich repeat C-terminal domain
    smart00255
    Location:639782
    TIR; Toll - interleukin 1 - resistance
    COG4886
    Location:48317
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    sd00031
    Location:5073
    LRR_1; leucine-rich repeat [structural motif]
    sd00033
    Location:355376
    LRR_RI; leucine-rich repeat [structural motif]
  5. XM_036164993.1XP_036020886.1  toll-like receptor 1 isoform X1

    UniProtKB/Swiss-Prot
    Q9EPW5
    UniProtKB/TrEMBL
    B9EJ46
    Conserved Domains (6) summary
    PRK15370
    Location:377487
    PRK15370; type III secretion system effector E3 ubiquitin transferase SlrP
    smart00082
    Location:527581
    LRRCT; Leucine rich repeat C-terminal domain
    smart00255
    Location:639782
    TIR; Toll - interleukin 1 - resistance
    COG4886
    Location:48317
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    sd00031
    Location:5073
    LRR_1; leucine-rich repeat [structural motif]
    sd00033
    Location:355376
    LRR_RI; leucine-rich repeat [structural motif]
  6. XM_006503851.4XP_006503914.1  toll-like receptor 1 isoform X1

    See identical proteins and their annotated locations for XP_006503914.1

    UniProtKB/Swiss-Prot
    Q9EPQ1, Q9EPW5
    UniProtKB/TrEMBL
    B9EJ46
    Conserved Domains (6) summary
    PRK15370
    Location:377487
    PRK15370; type III secretion system effector E3 ubiquitin transferase SlrP
    smart00082
    Location:527581
    LRRCT; Leucine rich repeat C-terminal domain
    smart00255
    Location:639782
    TIR; Toll - interleukin 1 - resistance
    COG4886
    Location:48317
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    sd00031
    Location:5073
    LRR_1; leucine-rich repeat [structural motif]
    sd00033
    Location:355376
    LRR_RI; leucine-rich repeat [structural motif]
  7. XM_011240720.4XP_011239022.1  toll-like receptor 1 isoform X1

    See identical proteins and their annotated locations for XP_011239022.1

    UniProtKB/Swiss-Prot
    Q9EPQ1, Q9EPW5
    UniProtKB/TrEMBL
    B9EJ46
    Conserved Domains (6) summary
    PRK15370
    Location:377487
    PRK15370; type III secretion system effector E3 ubiquitin transferase SlrP
    smart00082
    Location:527581
    LRRCT; Leucine rich repeat C-terminal domain
    smart00255
    Location:639782
    TIR; Toll - interleukin 1 - resistance
    COG4886
    Location:48317
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    sd00031
    Location:5073
    LRR_1; leucine-rich repeat [structural motif]
    sd00033
    Location:355376
    LRR_RI; leucine-rich repeat [structural motif]