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Tasor transcription activation suppressor [ Mus musculus (house mouse) ]

Gene ID: 218850, updated on 6-Jun-2024

Summary

Official Symbol
Tasorprovided by MGI
Official Full Name
transcription activation suppressorprovided by MGI
Primary source
MGI:MGI:1921694
See related
Ensembl:ENSMUSG00000040651 AllianceGenome:MGI:1921694
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Fam208a; MommeD6; D14Abb1e; 4732418E12; 4933409E02Rik
Summary
Predicted to enable chromatin binding activity. Involved in anterior/posterior axis specification, embryo and mesodermal to mesenchymal transition involved in gastrulation. Acts upstream of or within in utero embryonic development and mitotic spindle assembly. Predicted to be located in chromosome and nucleus. Predicted to be active in heterochromatin and nucleoplasm. Is expressed in several structures, including brain; ovary stratum granulosum; and seminiferous tubule. Orthologous to human TASOR (transcription activation suppressor). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in bladder adult (RPKM 7.4), CNS E18 (RPKM 6.8) and 28 other tissues See more
Orthologs
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Genomic context

See Tasor in Genome Data Viewer
Location:
14 A3; 14 16.51 cM
Exon count:
24
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (27150759..27205512)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (27423674..27483555)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene Rho guanine nucleotide exchange factor 3 Neighboring gene STARR-seq mESC enhancer starr_36271 Neighboring gene STARR-positive B cell enhancer ABC_E1891 Neighboring gene predicted gene, 52096 Neighboring gene predicted gene, 34702 Neighboring gene STARR-seq mESC enhancer starr_36272 Neighboring gene STARR-seq mESC enhancer starr_36273 Neighboring gene STARR-positive B cell enhancer ABC_E8897 Neighboring gene STARR-seq mESC enhancer starr_36274 Neighboring gene coiled-coil domain containing 66 Neighboring gene STARR-seq mESC enhancer starr_36275 Neighboring gene predicted gene, 25697 Neighboring gene predicted gene 7604

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Chemically induced (ENU) (2)  1 citation
  • Endonuclease-mediated (3) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables chromatin binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables chromatin binding ISO
Inferred from Sequence Orthology
more info
 
enables molecular_function ND
No biological Data available
more info
 
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
 
located_in chromosome IEA
Inferred from Electronic Annotation
more info
 
part_of heterochromatin IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of heterochromatin ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
protein TASOR
Names
family with sequence similarity 208, member A
protein FAM208A
retinoblastoma-associated protein 140
transgene activation suppressor protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001114879.3NP_001108351.1  protein TASOR isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC154327, CT485787
    UniProtKB/Swiss-Prot
    E9PUH2, Q69ZR9, Q9CUD3
    Conserved Domains (1) summary
    pfam12509
    Location:153314
    DUF3715; Protein of unknown function (DUF3715)
  2. NM_001404930.1NP_001391859.1  protein TASOR isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC154327, CT485787
    UniProtKB/Swiss-Prot
    E9PUH2, Q69ZR9, Q9CUD3
  3. NM_028945.3NP_083221.1  protein TASOR isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC154327, CT485787
    Consensus CDS
    CCDS49432.1
    UniProtKB/Swiss-Prot
    E9PUH2, Q69ZR9, Q9CUD3
    Related
    ENSMUSP00000022450.5, ENSMUST00000022450.6
    Conserved Domains (1) summary
    pfam12509
    Location:153314
    DUF3715; Protein of unknown function (DUF3715)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    27150759..27205512
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006518820.5XP_006518883.1  protein TASOR isoform X1

    UniProtKB/Swiss-Prot
    E9PUH2, Q69ZR9, Q9CUD3
    Conserved Domains (1) summary
    pfam12509
    Location:161314
    DUF3715; Protein of unknown function (DUF3715)

RNA

  1. XR_383159.5 RNA Sequence

  2. XR_383158.5 RNA Sequence

  3. XR_004938380.1 RNA Sequence