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Tk1 thymidine kinase 1 [ Mus musculus (house mouse) ]

Gene ID: 21877, updated on 8-Nov-2022

Summary

Official Symbol
Tk1provided by MGI
Official Full Name
thymidine kinase 1provided by MGI
Primary source
MGI:MGI:98763
See related
Ensembl:ENSMUSG00000025574 AllianceGenome:MGI:98763
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Tk-1; Tk1a; Tk1b; D530002A18Rik
Summary
Enables thymidine kinase activity. Predicted to be involved in protein homotetramerization and thymidine metabolic process. Predicted to act upstream of or within DNA biosynthetic process. Predicted to be located in cytosol. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; heart; and hemolymphoid system. Orthologous to human TK1 (thymidine kinase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in liver E14.5 (RPKM 50.7), liver E14 (RPKM 47.2) and 19 other tissues See more
Orthologs
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Genomic context

See Tk1 in Genome Data Viewer
Location:
11 E2; 11 82.96 cM
Exon count:
9
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (117706345..117716913, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (117815519..117826087, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 6030468B19 gene Neighboring gene synaptogyrin 2 Neighboring gene arylformamidase Neighboring gene baculoviral IAP repeat-containing 5 Neighboring gene VISTA enhancer mm780 Neighboring gene transmembrane protein 235

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (1)  1 citation
  • Endonuclease-mediated (3) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables thymidine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables thymidine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables thymidine kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
enables zinc ion binding ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
thymidine kinase, cytosolic
NP_001258658.1
NP_033413.2
XP_006533212.1
XP_036012517.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001271729.1NP_001258658.1  thymidine kinase, cytosolic isoform 2

    See identical proteins and their annotated locations for NP_001258658.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate coding exon compared to variant 1, that causes a frameshift and use of a downstream translation start site compared to variant 1. The resulting isoform (2) is shorter at the N-terminus compared to isoform 1.
    Source sequence(s)
    AA047942, AK139244, BY773001, CF732600
    UniProtKB/Swiss-Prot
    P04184
    Conserved Domains (1) summary
    cl23762
    Location:1161
    TK; Thymidine kinase
  2. NM_009387.2NP_033413.2  thymidine kinase, cytosolic isoform 1

    See identical proteins and their annotated locations for NP_033413.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AA047942, AK139244, BY773001
    Consensus CDS
    CCDS25692.1
    UniProtKB/Swiss-Prot
    P04184, Q921J8
    Related
    ENSMUSP00000026661.4, ENSMUST00000026661.4
    Conserved Domains (1) summary
    cl23762
    Location:18197
    TK; Thymidine kinase

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    117706345..117716913 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036156624.1XP_036012517.1  thymidine kinase, cytosolic isoform X2

    Conserved Domains (1) summary
    cl23762
    Location:1161
    TK; Thymidine kinase
  2. XM_006533149.3XP_006533212.1  thymidine kinase, cytosolic isoform X1

    Conserved Domains (1) summary
    cl23762
    Location:41199
    TK; Thymidine kinase

RNA

  1. XR_004936934.1 RNA Sequence