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Serinc5 serine incorporator 5 [ Mus musculus (house mouse) ]

Gene ID: 218442, updated on 12-May-2024

Summary

Official Symbol
Serinc5provided by MGI
Official Full Name
serine incorporator 5provided by MGI
Primary source
MGI:MGI:2444223
See related
Ensembl:ENSMUSG00000021703 AllianceGenome:MGI:2444223
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
TPO1; AIGP3; A130038L21Rik
Summary
Acts upstream of or within myelination. Located in Golgi apparatus and myelin sheath. Is expressed in several structures, including central nervous system; forelimb; phalanx; retina; and tooth. Orthologous to human SERINC5 (serine incorporator 5). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in thymus adult (RPKM 31.9), ovary adult (RPKM 22.9) and 28 other tissues See more
Orthologs
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Genomic context

See Serinc5 in Genome Data Viewer
Location:
13 C3; 13 47.75 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (92747646..92848455)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (92611138..92711947)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_35268 Neighboring gene predicted gene, 52060 Neighboring gene zinc finger, FYVE domain containing 16 Neighboring gene spermatogenic leucine zipper 1 Neighboring gene STARR-positive B cell enhancer ABC_E2417 Neighboring gene STARR-positive B cell enhancer ABC_E9153 Neighboring gene predicted gene, 41018 Neighboring gene STARR-positive B cell enhancer ABC_E10807 Neighboring gene STARR-seq mESC enhancer starr_35273 Neighboring gene peptidylprolyl isomerase A (Ppia) pseudogene Neighboring gene thrombospondin 4

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2)  1 citation
  • Gene trapped (1) 

General gene information

Markers

Gene Ontology Provided by MGI

Process Evidence Code Pubs
involved_in defense response to virus ISO
Inferred from Sequence Orthology
more info
 
involved_in detection of virus ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within immune system process IEA
Inferred from Electronic Annotation
more info
 
involved_in innate immune response ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within myelination IDA
Inferred from Direct Assay
more info
PubMed 
involved_in phosphatidylserine metabolic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within phospholipid biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
PubMed 
located_in centrosome ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in myelin sheath IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
serine incorporator 5
Names
AIGP-3
axotomy-induced glycoprotein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_172588.2NP_766176.1  serine incorporator 5

    See identical proteins and their annotated locations for NP_766176.1

    Status: PROVISIONAL

    Source sequence(s)
    BC062131
    Consensus CDS
    CCDS36744.1
    UniProtKB/Swiss-Prot
    Q80ZH8, Q8BHJ6, Q8CHM0
    Related
    ENSMUSP00000047547.8, ENSMUST00000049488.9
    Conserved Domains (1) summary
    pfam03348
    Location:13458
    Serinc; Serine incorporator (Serinc)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    92747646..92848455
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)