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Tia1 cytotoxic granule-associated RNA binding protein 1 [ Mus musculus (house mouse) ]

Gene ID: 21841, updated on 5-Aug-2018

Summary

Official Symbol
Tia1provided by MGI
Official Full Name
cytotoxic granule-associated RNA binding protein 1provided by MGI
Primary source
MGI:MGI:107914
See related
Ensembl:ENSMUSG00000071337 Vega:OTTMUSG00000022840
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
TIA-1; mTIA-1; AI256674; 2310050N03Rik
Expression
Broad expression in CNS E14 (RPKM 41.1), whole brain E14.5 (RPKM 40.1) and 19 other tissues See more
Orthologs

Genomic context

See Tia1 in Genome Data Viewer
Location:
6; 6 D1
Exon count:
15
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 6 NC_000072.6 (86404219..86433405)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 6 NC_000072.5 (86354213..86383399)

Chromosome 6 - NC_000072.6Genomic Context describing neighboring genes Neighboring gene prenylcysteine oxidase 1 Neighboring gene nuclear encoded tRNA glycine 4 (anticodon CCC) Neighboring gene expressed sequence C87436 Neighboring gene RIKEN cDNA A430078I02 gene Neighboring gene predicted gene, 38849

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
AU-rich element binding IDA
Inferred from Direct Assay
more info
PubMed 
RNA binding IEA
Inferred from Electronic Annotation
more info
 
nucleic acid binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
apoptotic process IEA
Inferred from Electronic Annotation
more info
 
negative regulation of cytokine biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of translation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of epithelial cell apoptotic process ISO
Inferred from Sequence Orthology
more info
 
protein localization to cytoplasmic stress granule ISO
Inferred from Sequence Orthology
more info
 
regulation of mRNA splicing, via spliceosome ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
cytoplasmic stress granule IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasmic stress granule ISO
Inferred from Sequence Orthology
more info
PubMed 
cytosol ISO
Inferred from Sequence Orthology
more info
 
nuclear stress granule IDA
Inferred from Direct Assay
more info
PubMed 
nuclear stress granule ISO
Inferred from Sequence Orthology
more info
PubMed 
nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus ISO
Inferred from Sequence Orthology
more info
 
ribonucleoprotein complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
nucleolysin TIA-1
Names
RNA-binding protein TIA-1
T-cell-restricted intracellular antigen-1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001164078.1NP_001157550.1  nucleolysin TIA-1 isoform 2

    See identical proteins and their annotated locations for NP_001157550.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region and lacks an alternate in-frame exon in the central coding region compared to variant 1. The resulting isoform (2) includes a two-aa segment and lacks a second internal segment, compared to isoform 1.
    Source sequence(s)
    AC153374, BC046812
    Consensus CDS
    CCDS51834.1
    UniProtKB/TrEMBL
    Q80ZW7
    Related
    ENSMUSP00000109342.2, OTTMUSP00000026225, ENSMUST00000113713.8, OTTMUST00000054890
    Conserved Domains (4) summary
    cd12618
    Location:96175
    RRM2_TIA1; RNA recognition motif 2 in nucleolysin TIA-1 isoform p40 (p40-TIA-1) and similar proteins
    cd12621
    Location:205278
    RRM3_TIA1; RNA recognition motif 3 in nucleolysin TIA-1 isoform p40 (p40-TIA-1) and similar proteins
    TIGR01661
    Location:6271
    ELAV_HUD_SF; ELAV/HuD family splicing factor
    cl17169
    Location:883
    RRM_SF; RNA recognition motif (RRM) superfamily
  2. NM_001164079.1NP_001157551.1  nucleolysin TIA-1 isoform 3

    See identical proteins and their annotated locations for NP_001157551.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks three alternate in-frame exons, compared to variant 1. The resulting isoform (3) lacks two internal segments, compared to isoform 1.
    Source sequence(s)
    AC153374
    Consensus CDS
    CCDS51833.1
    UniProtKB/TrEMBL
    Q8CII5
    Related
    ENSMUSP00000118558.1, OTTMUSP00000026223, ENSMUST00000130967.7, OTTMUST00000054885
    Conserved Domains (2) summary
    cd12618
    Location:94173
    RRM2_TIA1; RNA recognition motif 2 in nucleolysin TIA-1 isoform p40 (p40-TIA-1) and similar proteins
    cl17169
    Location:881
    RRM_SF; RNA recognition motif (RRM) superfamily
  3. NM_011585.4NP_035715.1  nucleolysin TIA-1 isoform 1

    See identical proteins and their annotated locations for NP_035715.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC153374, U55862
    Consensus CDS
    CCDS20312.1
    UniProtKB/Swiss-Prot
    P52912
    UniProtKB/TrEMBL
    Q564E7
    Related
    ENSMUSP00000093425.2, OTTMUSP00000026222, ENSMUST00000095753.8, OTTMUST00000054884
    Conserved Domains (4) summary
    cd12615
    Location:881
    RRM1_TIA1; RNA recognition motif 1 in nucleolysin TIA-1 isoform p40 (p40-TIA-1) and similar proteins
    cd12618
    Location:105184
    RRM2_TIA1; RNA recognition motif 2 in nucleolysin TIA-1 isoform p40 (p40-TIA-1) and similar proteins
    cd12621
    Location:214287
    RRM3_TIA1; RNA recognition motif 3 in nucleolysin TIA-1 isoform p40 (p40-TIA-1) and similar proteins
    TIGR01661
    Location:6280
    ELAV_HUD_SF; ELAV/HuD family splicing factor

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000072.6 Reference GRCm38.p4 C57BL/6J

    Range
    86404219..86433405
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017321512.1XP_017177001.1  nucleolysin TIA-1 isoform X2

  2. XM_006505891.2XP_006505954.1  nucleolysin TIA-1 isoform X3

    Conserved Domains (3) summary
    cd12615
    Location:881
    RRM1_TIA1; RNA recognition motif 1 in nucleolysin TIA-1 isoform p40 (p40-TIA-1) and similar proteins
    cd12618
    Location:105184
    RRM2_TIA1; RNA recognition motif 2 in nucleolysin TIA-1 isoform p40 (p40-TIA-1) and similar proteins
    cl17169
    Location:214255
    RRM_SF; RNA recognition motif (RRM) superfamily
  3. XM_006505889.2XP_006505952.1  nucleolysin TIA-1 isoform X1

    See identical proteins and their annotated locations for XP_006505952.1

    UniProtKB/TrEMBL
    G5E8L2
    Related
    ENSMUSP00000093424.2, OTTMUSP00000026224, ENSMUST00000095752.8, OTTMUST00000054886
    Conserved Domains (4) summary
    cd12618
    Location:94173
    RRM2_TIA1; RNA recognition motif 2 in nucleolysin TIA-1 isoform p40 (p40-TIA-1) and similar proteins
    cd12621
    Location:203276
    RRM3_TIA1; RNA recognition motif 3 in nucleolysin TIA-1 isoform p40 (p40-TIA-1) and similar proteins
    TIGR01661
    Location:6269
    ELAV_HUD_SF; ELAV/HuD family splicing factor
    cl17169
    Location:881
    RRM_SF; RNA recognition motif (RRM) superfamily
  4. XM_011241285.2XP_011239587.1  nucleolysin TIA-1 isoform X4

    Conserved Domains (2) summary
    cd12618
    Location:483
    RRM2_TIA1; RNA recognition motif 2 in nucleolysin TIA-1 isoform p40 (p40-TIA-1) and similar proteins
    cl17169
    Location:113186
    RRM_SF; RNA recognition motif (RRM) superfamily
  5. XM_017321513.1XP_017177002.1  nucleolysin TIA-1 isoform X5

    Conserved Domains (1) summary
    cl17169
    Location:74147
    RRM_SF; RNA recognition motif (RRM) superfamily
  6. XM_011241286.2XP_011239588.1  nucleolysin TIA-1 isoform X5

    See identical proteins and their annotated locations for XP_011239588.1

    Conserved Domains (1) summary
    cl17169
    Location:74147
    RRM_SF; RNA recognition motif (RRM) superfamily
  7. XM_017321514.1XP_017177003.1  nucleolysin TIA-1 isoform X5

    Conserved Domains (1) summary
    cl17169
    Location:74147
    RRM_SF; RNA recognition motif (RRM) superfamily
  8. XM_006505893.3XP_006505956.1  nucleolysin TIA-1 isoform X5

    See identical proteins and their annotated locations for XP_006505956.1

    Conserved Domains (1) summary
    cl17169
    Location:74147
    RRM_SF; RNA recognition motif (RRM) superfamily

RNA

  1. XR_377438.3 RNA Sequence

    Related
    ENSMUST00000113712.9, OTTMUST00000054888
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