U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Tia1 cytotoxic granule-associated RNA binding protein 1 [ Mus musculus (house mouse) ]

Gene ID: 21841, updated on 12-May-2024

Summary

Official Symbol
Tia1provided by MGI
Official Full Name
cytotoxic granule-associated RNA binding protein 1provided by MGI
Primary source
MGI:MGI:107914
See related
Ensembl:ENSMUSG00000071337 AllianceGenome:MGI:107914
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
TIA-1; mTIA-1; 2310050N03Rik
Summary
Enables mRNA 3'-UTR AU-rich region binding activity. Acts upstream of or within negative regulation of cytokine production and negative regulation of translation. Located in cytoplasmic stress granule and nuclear stress granule. Is expressed in several structures, including alimentary system; central nervous system; metanephros; respiratory system; and sensory organ. Orthologous to human TIA1 (TIA1 cytotoxic granule associated RNA binding protein). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in CNS E14 (RPKM 41.1), whole brain E14.5 (RPKM 40.1) and 19 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Tia1 in Genome Data Viewer
Location:
6 D1; 6 37.69 cM
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (86381001..86410387)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (86404203..86433405)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene prenylcysteine oxidase 1 Neighboring gene STARR-positive B cell enhancer ABC_E11322 Neighboring gene STARR-seq mESC enhancer starr_16526 Neighboring gene nuclear encoded tRNA glycine 4 (anticodon CCC) Neighboring gene STARR-positive B cell enhancer ABC_E6450 Neighboring gene STARR-positive B cell enhancer ABC_E8112 Neighboring gene expressed sequence C87436 Neighboring gene STARR-seq mESC enhancer starr_16527 Neighboring gene RIKEN cDNA A430078I02 gene Neighboring gene RIKEN cDNA 2310040G24 gene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Targeted (3)  1 citation

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA binding ISO
Inferred from Sequence Orthology
more info
 
enables mRNA 3'-UTR AU-rich region binding IDA
Inferred from Direct Assay
more info
PubMed 
enables mRNA 3'-UTR binding IDA
Inferred from Direct Assay
more info
PubMed 
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasmic stress granule IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasmic stress granule ISO
Inferred from Sequence Orthology
more info
PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in nuclear stress granule IDA
Inferred from Direct Assay
more info
PubMed 
located_in nuclear stress granule ISO
Inferred from Sequence Orthology
more info
PubMed 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
part_of ribonucleoprotein complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
cytotoxic granule associated RNA binding protein TIA1
Names
RNA-binding protein TIA-1
T-cell-restricted intracellular antigen-1
nucleolysin TIA-1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001164078.1NP_001157550.1  cytotoxic granule associated RNA binding protein TIA1 isoform 2

    See identical proteins and their annotated locations for NP_001157550.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region and lacks an alternate in-frame exon in the central coding region compared to variant 1. The resulting isoform (2) includes a two-aa segment and lacks a second internal segment, compared to isoform 1.
    Source sequence(s)
    AC153374, BC046812
    Consensus CDS
    CCDS51834.1
    UniProtKB/TrEMBL
    D3Z4H6, Q80ZW7
    Related
    ENSMUSP00000109342.3, ENSMUST00000113713.9
    Conserved Domains (4) summary
    cd12618
    Location:96175
    RRM2_TIA1; RNA recognition motif 2 in nucleolysin TIA-1 isoform p40 (p40-TIA-1) and similar proteins
    cd12621
    Location:205278
    RRM3_TIA1; RNA recognition motif 3 in nucleolysin TIA-1 isoform p40 (p40-TIA-1) and similar proteins
    TIGR01661
    Location:6271
    ELAV_HUD_SF; ELAV/HuD family splicing factor
    cl17169
    Location:883
    RRM_SF; RNA recognition motif (RRM) superfamily
  2. NM_001164079.1NP_001157551.1  cytotoxic granule associated RNA binding protein TIA1 isoform 3

    See identical proteins and their annotated locations for NP_001157551.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks three alternate in-frame exons, compared to variant 1. The resulting isoform (3) lacks two internal segments, compared to isoform 1.
    Source sequence(s)
    AC153374
    Consensus CDS
    CCDS51833.1
    UniProtKB/TrEMBL
    Q8CII5
    Related
    ENSMUSP00000118558.2, ENSMUST00000130967.8
    Conserved Domains (2) summary
    cd12618
    Location:94173
    RRM2_TIA1; RNA recognition motif 2 in nucleolysin TIA-1 isoform p40 (p40-TIA-1) and similar proteins
    cl17169
    Location:881
    RRM_SF; RNA recognition motif (RRM) superfamily
  3. NM_011585.4NP_035715.1  cytotoxic granule associated RNA binding protein TIA1 isoform 1

    See identical proteins and their annotated locations for NP_035715.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC153374, U55862
    Consensus CDS
    CCDS20312.1
    UniProtKB/Swiss-Prot
    P52912
    UniProtKB/TrEMBL
    D3Z4H6, Q564E7
    Related
    ENSMUSP00000093425.3, ENSMUST00000095753.9
    Conserved Domains (4) summary
    cd12615
    Location:881
    RRM1_TIA1; RNA recognition motif 1 in nucleolysin TIA-1 isoform p40 (p40-TIA-1) and similar proteins
    cd12618
    Location:105184
    RRM2_TIA1; RNA recognition motif 2 in nucleolysin TIA-1 isoform p40 (p40-TIA-1) and similar proteins
    cd12621
    Location:214287
    RRM3_TIA1; RNA recognition motif 3 in nucleolysin TIA-1 isoform p40 (p40-TIA-1) and similar proteins
    TIGR01661
    Location:6280
    ELAV_HUD_SF; ELAV/HuD family splicing factor

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    86381001..86410387
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006505891.4XP_006505954.1  cytotoxic granule associated RNA binding protein TIA1 isoform X3

    Conserved Domains (3) summary
    cd12615
    Location:881
    RRM1_TIA1; RNA recognition motif 1 in nucleolysin TIA-1 isoform p40 (p40-TIA-1) and similar proteins
    cd12618
    Location:105184
    RRM2_TIA1; RNA recognition motif 2 in nucleolysin TIA-1 isoform p40 (p40-TIA-1) and similar proteins
    cl17169
    Location:214255
    RRM_SF; RNA recognition motif (RRM) superfamily
  2. XM_017321512.3XP_017177001.1  cytotoxic granule associated RNA binding protein TIA1 isoform X2

    Conserved Domains (3) summary
    cd12618
    Location:105184
    RRM2_TIA1; RNA recognition motif 2 in nucleolysin TIA-1 isoform p40 (p40-TIA-1) and similar proteins
    cd12621
    Location:214287
    RRM3_TIA1; RNA recognition motif 3 in nucleolysin TIA-1 isoform p40 (p40-TIA-1) and similar proteins
    cl17169
    Location:881
    RRM_SF; RNA recognition motif (RRM) superfamily
  3. XM_006505889.4XP_006505952.1  cytotoxic granule associated RNA binding protein TIA1 isoform X1

    See identical proteins and their annotated locations for XP_006505952.1

    UniProtKB/TrEMBL
    D3Z4H6, G5E8L2
    Related
    ENSMUSP00000093424.3, ENSMUST00000095752.9
    Conserved Domains (3) summary
    cd12618
    Location:94173
    RRM2_TIA1; RNA recognition motif 2 in nucleolysin TIA-1 isoform p40 (p40-TIA-1) and similar proteins
    cd12621
    Location:203276
    RRM3_TIA1; RNA recognition motif 3 in nucleolysin TIA-1 isoform p40 (p40-TIA-1) and similar proteins
    cl17169
    Location:881
    RRM_SF; RNA recognition motif (RRM) superfamily
  4. XM_017321513.3XP_017177002.1  cytotoxic granule associated RNA binding protein TIA1 isoform X5

    Conserved Domains (3) summary
    TIGR01628
    Location:4239
    PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
    cd12620
    Location:74146
    RRM3_TIAR; RNA recognition motif 3 (RRM3) found in nucleolysin TIAR and similar proteins
    cl17169
    Location:141
    RRM_SF; RNA recognition motif (RRM) superfamily
  5. XM_036166017.1XP_036021910.1  cytotoxic granule associated RNA binding protein TIA1 isoform X5

    Conserved Domains (3) summary
    TIGR01628
    Location:4239
    PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
    cd12620
    Location:74146
    RRM3_TIAR; RNA recognition motif 3 (RRM3) found in nucleolysin TIAR and similar proteins
    cl17169
    Location:141
    RRM_SF; RNA recognition motif (RRM) superfamily
  6. XM_036166018.1XP_036021911.1  cytotoxic granule associated RNA binding protein TIA1 isoform X5

    Conserved Domains (3) summary
    TIGR01628
    Location:4239
    PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
    cd12620
    Location:74146
    RRM3_TIAR; RNA recognition motif 3 (RRM3) found in nucleolysin TIAR and similar proteins
    cl17169
    Location:141
    RRM_SF; RNA recognition motif (RRM) superfamily
  7. XM_036166016.1XP_036021909.1  cytotoxic granule associated RNA binding protein TIA1 isoform X4

    Conserved Domains (2) summary
    cd12620
    Location:113185
    RRM3_TIAR; RNA recognition motif 3 (RRM3) found in nucleolysin TIAR and similar proteins
    cd12353
    Location:680
    RRM2_TIA1_like; RNA recognition motif 2 (RRM2) found in granule-associated RNA binding proteins p40-TIA-1 and TIAR
  8. XM_036166020.1XP_036021913.1  cytotoxic granule associated RNA binding protein TIA1 isoform X6

    Conserved Domains (2) summary
    cd12618
    Location:380
    RRM2_TIA1; RNA recognition motif 2 (RRM2) found in nucleolysin TIA-1 isoform p40 (p40-TIA-1) and similar proteins
    cl17169
    Location:113154
    RRM_SF; RNA recognition motif (RRM) superfamily
  9. XM_006505893.5XP_006505956.1  cytotoxic granule associated RNA binding protein TIA1 isoform X5

    See identical proteins and their annotated locations for XP_006505956.1

    Conserved Domains (3) summary
    TIGR01628
    Location:4239
    PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
    cd12620
    Location:74146
    RRM3_TIAR; RNA recognition motif 3 (RRM3) found in nucleolysin TIAR and similar proteins
    cl17169
    Location:141
    RRM_SF; RNA recognition motif (RRM) superfamily
  10. XM_011241285.4XP_011239587.1  cytotoxic granule associated RNA binding protein TIA1 isoform X4

    Conserved Domains (2) summary
    cd12620
    Location:113185
    RRM3_TIAR; RNA recognition motif 3 (RRM3) found in nucleolysin TIAR and similar proteins
    cd12353
    Location:680
    RRM2_TIA1_like; RNA recognition motif 2 (RRM2) found in granule-associated RNA binding proteins p40-TIA-1 and TIAR
  11. XM_030255313.1XP_030111173.1  cytotoxic granule associated RNA binding protein TIA1 isoform X5

    Conserved Domains (3) summary
    TIGR01628
    Location:4239
    PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
    cd12620
    Location:74146
    RRM3_TIAR; RNA recognition motif 3 (RRM3) found in nucleolysin TIAR and similar proteins
    cl17169
    Location:141
    RRM_SF; RNA recognition motif (RRM) superfamily
  12. XM_036166019.1XP_036021912.1  cytotoxic granule associated RNA binding protein TIA1 isoform X5

    Conserved Domains (3) summary
    TIGR01628
    Location:4239
    PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
    cd12620
    Location:74146
    RRM3_TIAR; RNA recognition motif 3 (RRM3) found in nucleolysin TIAR and similar proteins
    cl17169
    Location:141
    RRM_SF; RNA recognition motif (RRM) superfamily

RNA

  1. XR_003956185.2 RNA Sequence

  2. XR_004942934.1 RNA Sequence

  3. XR_004942933.1 RNA Sequence

  4. XR_004942935.1 RNA Sequence

  5. XR_377438.5 RNA Sequence

    Related
    ENSMUST00000113712.10
  6. XR_003956184.2 RNA Sequence