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Rasa1 RAS p21 protein activator 1 [ Mus musculus (house mouse) ]

Gene ID: 218397, updated on 31-Jan-2019

Summary

Official Symbol
Rasa1provided by MGI
Official Full Name
RAS p21 protein activator 1provided by MGI
Primary source
MGI:MGI:97860
See related
Ensembl:ENSMUSG00000021549
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gap; Rasa; RasGAP
Expression
Ubiquitous expression in CNS E14 (RPKM 8.0), CNS E11.5 (RPKM 7.1) and 28 other tissues See more
Orthologs

Genomic context

See Rasa1 in Genome Data Viewer
Location:
13 C3; 13 45.05 cM
Exon count:
26
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 13 NC_000079.6 (85214699..85289493, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 13 NC_000079.5 (85354304..85429091, complement)

Chromosome 13 - NC_000079.6Genomic Context describing neighboring genes Neighboring gene smoothened homolog pseudogene Neighboring gene cyclin H Neighboring gene high mobility group box 3 pseudogene Neighboring gene NHP2-like protein 1 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC7759

Gene Ontology Provided by MGI

Function Evidence Code Pubs
GTPase activator activity ISO
Inferred from Sequence Orthology
more info
 
GTPase binding ISO
Inferred from Sequence Orthology
more info
 
ion channel binding ISO
Inferred from Sequence Orthology
more info
 
kinase binding ISO
Inferred from Sequence Orthology
more info
 
phosphotyrosine residue binding ISO
Inferred from Sequence Orthology
more info
 
platelet-derived growth factor receptor binding ISO
Inferred from Sequence Orthology
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase B binding ISO
Inferred from Sequence Orthology
more info
 
protein tyrosine kinase binding ISO
Inferred from Sequence Orthology
more info
 
protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
 
receptor tyrosine kinase binding ISO
Inferred from Sequence Orthology
more info
 
signaling receptor binding ISO
Inferred from Sequence Orthology
more info
 
transcription factor binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
activation of GTPase activity ISO
Inferred from Sequence Orthology
more info
 
blood vessel morphogenesis ISO
Inferred from Sequence Orthology
more info
 
cellular response to epidermal growth factor stimulus ISO
Inferred from Sequence Orthology
more info
 
cellular response to platelet-derived growth factor stimulus ISO
Inferred from Sequence Orthology
more info
 
negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
negative regulation of cell adhesion ISO
Inferred from Sequence Orthology
more info
 
negative regulation of cell-matrix adhesion ISO
Inferred from Sequence Orthology
more info
 
positive regulation of GTPase activity ISO
Inferred from Sequence Orthology
more info
 
positive regulation of fibroblast proliferation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of glucose import ISO
Inferred from Sequence Orthology
more info
 
positive regulation of peptidyl-tyrosine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
regulation of actin filament polymerization ISO
Inferred from Sequence Orthology
more info
 
response to drug ISO
Inferred from Sequence Orthology
more info
 
signal transduction ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
cytosol ISO
Inferred from Sequence Orthology
more info
 
membrane ISO
Inferred from Sequence Orthology
more info
 
nuclear membrane ISO
Inferred from Sequence Orthology
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane ISO
Inferred from Sequence Orthology
more info
 
ruffle IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
ras GTPase-activating protein 1
Names
GTPase-activating protein
p120-rasGAP

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_145452.3NP_663427.2  ras GTPase-activating protein 1

    Status: VALIDATED

    Source sequence(s)
    BB645489, BC065082, BU055087, CF534745, CV555618
    Consensus CDS
    CCDS26667.2
    UniProtKB/TrEMBL
    E9PYG6
    Related
    ENSMUSP00000105179.2, ENSMUST00000109552.2
    Conserved Domains (8) summary
    cd08400
    Location:582707
    C2_Ras_p21A1; C2 domain present in RAS p21 protein activator 1 (RasA1)
    cd10353
    Location:152255
    SH2_Nterm_RasGAP; N-terminal Src homology 2 (SH2) domain found in Ras GTPase-activating protein 1 (GAP)
    cd10354
    Location:341417
    SH2_Cterm_RasGAP; C-terminal Src homology 2 (SH2) domain found in Ras GTPase-activating protein 1 (GAP)
    cd11788
    Location:272330
    SH3_RasGAP; Src Homology 3 domain of Ras GTPase-Activating Protein 1
    cd05391
    Location:7051036
    RasGAP_p120GAP; Ras-GTPase Activating Domain of p120
    smart00323
    Location:6891035
    RasGAP; GTPase-activator protein for Ras-like GTPases
    cd13260
    Location:480567
    PH_RASA1; RAS p21 protein activator (GTPase activating protein) 1 Pleckstrin homology (PH) domain
    pfam00169
    Location:480568
    PH; PH domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000079.6 Reference GRCm38.p4 C57BL/6J

    Range
    85214699..85289493 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011244518.2XP_011242820.1  ras GTPase-activating protein 1 isoform X1

    Conserved Domains (7) summary
    cd08400
    Location:582707
    C2_Ras_p21A1; C2 domain present in RAS p21 protein activator 1 (RasA1)
    cd10353
    Location:152255
    SH2_Nterm_RasGAP; N-terminal Src homology 2 (SH2) domain found in Ras GTPase-activating protein 1 (GAP)
    cd10354
    Location:341417
    SH2_Cterm_RasGAP; C-terminal Src homology 2 (SH2) domain found in Ras GTPase-activating protein 1 (GAP)
    cd11788
    Location:272330
    SH3_RasGAP; Src Homology 3 domain of Ras GTPase-Activating Protein 1
    pfam00169
    Location:480568
    PH; PH domain
    cl02569
    Location:705887
    RasGAP; Ras GTPase Activating Domain
    cl17171
    Location:480567
    PH-like; Pleckstrin homology-like domain
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