Clptm1l CLPTM1-like [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Clptm1lprovided by MGI
Official Full Name: CLPTM1-likeprovided by MGI
Primary source: MGI:MGI:2442892
See related: Ensembl:ENSMUSG00000021610 AllianceGenome:MGI:2442892
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Crr9; CRR9p; C130052I12Rik
Summary: Predicted to act upstream of or within apoptotic process. Predicted to be integral component of membrane. Predicted to be active in membrane. Is expressed in embryo; retina; and white fat. Orthologous to human CLPTM1L (CLPTM1 like). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in genital fat pad adult (RPKM 55.3), ovary adult (RPKM 54.4) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 13; 13 C1

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
109	current	GRCm39 (GCF_000001635.27)	13	NC_000079.7 (73752121..73768758)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	13	NC_000079.6 (73604002..73620639)

Chromosome 13 - NC_000079.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (3) 1 citation
Endonuclease-mediated (3)

General gene information

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Homology

Homologs of the Clptm1l gene: The Clptm1l gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, rat, chicken, zebrafish, fruit fly, mosquito, C.elegans, and frog.
Orthologs from Annotation Pipeline: 503 organisms have orthologs with human gene Clptm1l
Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info
enables phospholipid scramblase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in biological_process	ND No biological Data available more info
acts_upstream_of_or_within lipid transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in endomembrane system	IBA Inferred from Biological aspect of Ancestor more info	PubMed
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum membrane	ISO Inferred from Sequence Orthology more info
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info	PubMed

General protein information

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Preferred Names: lipid scramblase CLPTM1L

Names: CLPTM1-like protein; cisplatin resistance related protein CRR9p; cisplatin resistance-related protein 9; cleft lip and palate transmembrane protein 1-like protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_146047.2 → NP_666159.2 lipid scramblase CLPTM1L

Status: VALIDATED

Source sequence(s)

AC158359, AK032295, AK048357

Consensus CDS

CCDS56894.1

UniProtKB/Swiss-Prot

Q8BXA5, Q8R0P2

UniProtKB/TrEMBL

A0A6P5QQJ6, A0A8C6HGK7

Related

ENSMUSP00000022102.8, ENSMUST00000022102.9

Conserved Domains (1) summary

pfam05602
Location:22 → 422

CLPTM1; Cleft lip and palate transmembrane protein 1 (CLPTM1)