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Cdc14b CDC14 cell division cycle 14B [ Mus musculus (house mouse) ]

Gene ID: 218294, updated on 8-Dec-2022

Summary

Official Symbol
Cdc14bprovided by MGI
Official Full Name
CDC14 cell division cycle 14Bprovided by MGI
Primary source
MGI:MGI:2441808
See related
Ensembl:ENSMUSG00000033102 AllianceGenome:MGI:2441808
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CDC14B3; Cdc14B1; 2810432N10Rik; A530086E13Rik
Summary
Predicted to enable protein serine/threonine phosphatase activity and protein tyrosine phosphatase activity. Predicted to be involved in cilium assembly; microtubule cytoskeleton organization; and regulation of cell cycle process. Predicted to act upstream of or within DNA repair. Predicted to be located in nucleoplasm. Predicted to be active in cytoplasm; microtubule cytoskeleton; and nucleolus. Is expressed in embryo. Orthologous to several human genes including CDC14B (cell division cycle 14B). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis adult (RPKM 6.1), placenta adult (RPKM 2.9) and 28 other tissues See more
Orthologs
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Genomic context

See Cdc14b in Genome Data Viewer
Location:
13; 13 B3
Exon count:
20
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (64337085..64423670, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (64192545..64274988, complement)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene zinc finger protein 367 Neighboring gene hyaluronic acid binding protein 4 Neighboring gene predicted gene, 46424 Neighboring gene RIKEN cDNA 1810034E14 gene Neighboring gene peroxiredoxin like 2C Neighboring gene predicted gene, 31128

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (3)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables myosin phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
enables phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
enables phosphoprotein phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein serine/threonine phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein serine/threonine phosphatase activity ISO
Inferred from Sequence Orthology
more info
 
enables protein tyrosine phosphatase activity ISO
Inferred from Sequence Orthology
more info
 
enables protein tyrosine/serine/threonine phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within DNA repair IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cellular response to DNA damage stimulus IEA
Inferred from Electronic Annotation
more info
 
involved_in cilium assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in dephosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in microtubule cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of cytokinesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in protein dephosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of exit from mitosis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in centrosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in mitotic spindle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in nucleolus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
is_active_in spindle pole IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
dual specificity protein phosphatase CDC14B
Names
CDC14 cell division cycle 14 homolog B
NP_001116461.1
NP_766175.3
XP_006517282.1
XP_006517290.1
XP_006517292.1
XP_011242817.1
XP_036013890.1
XP_036013891.1
XP_036013892.1
XP_036013893.1
XP_036013894.1
XP_036013895.1
XP_036013896.1
XP_036013897.1
XP_036013898.1
XP_036013899.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001122989.1NP_001116461.1  dual specificity protein phosphatase CDC14B isoform 2

    See identical proteins and their annotated locations for NP_001116461.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and 5' coding region, compared to variant 1, resulting in the use of a novel start codon and a protein (isoform 2) with a shorter, distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AK036045, AK041155, BY199064
    Consensus CDS
    CCDS49292.1
    UniProtKB/Swiss-Prot
    Q6PFY9
    Related
    ENSMUSP00000105391.3, ENSMUST00000109769.10
    Conserved Domains (2) summary
    pfam14671
    Location:17151
    DSPn; Dual specificity protein phosphatase, N-terminal half
    cl21483
    Location:209323
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
  2. NM_172587.3NP_766175.3  dual specificity protein phosphatase CDC14B isoform 1

    See identical proteins and their annotated locations for NP_766175.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK036045, AK041155, AK044332, CN720173
    Consensus CDS
    CCDS26598.1
    UniProtKB/Swiss-Prot
    Q6PFY9, Q8BLV5
    Related
    ENSMUSP00000046003.9, ENSMUST00000039318.16
    Conserved Domains (2) summary
    cd14499
    Location:199372
    CDC14_C; C-terminal dual-specificity phosphatase domain of CDC14 family proteins
    cd17657
    Location:52190
    CDC14_N; N-terminal domain pseudophosphatase domain of CDC14 family proteins

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    64337085..64423670 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036158005.1XP_036013898.1  dual specificity protein phosphatase CDC14B isoform X11

    Conserved Domains (2) summary
    cd14499
    Location:199372
    CDC14_C; C-terminal dual-specificity phosphatase domain of CDC14 family proteins
    cd17657
    Location:52190
    CDC14_N; N-terminal domain pseudophosphatase domain of CDC14 family proteins
  2. XM_036157997.1XP_036013890.1  dual specificity protein phosphatase CDC14B isoform X1

    Conserved Domains (2) summary
    cd14499
    Location:199372
    CDC14_C; C-terminal dual-specificity phosphatase domain of CDC14 family proteins
    cd17657
    Location:52190
    CDC14_N; N-terminal domain pseudophosphatase domain of CDC14 family proteins
  3. XM_036158001.1XP_036013894.1  dual specificity protein phosphatase CDC14B isoform X6

    Conserved Domains (2) summary
    cd14499
    Location:199372
    CDC14_C; C-terminal dual-specificity phosphatase domain of CDC14 family proteins
    cd17657
    Location:52190
    CDC14_N; N-terminal domain pseudophosphatase domain of CDC14 family proteins
  4. XM_036158000.1XP_036013893.1  dual specificity protein phosphatase CDC14B isoform X5

    UniProtKB/TrEMBL
    A0A1Y7VJB9
    Related
    ENSMUSP00000152388.2, ENSMUST00000221634.2
    Conserved Domains (2) summary
    cd14499
    Location:199372
    CDC14_C; C-terminal dual-specificity phosphatase domain of CDC14 family proteins
    cd17657
    Location:52190
    CDC14_N; N-terminal domain pseudophosphatase domain of CDC14 family proteins
  5. XM_036157998.1XP_036013891.1  dual specificity protein phosphatase CDC14B isoform X3

    Conserved Domains (2) summary
    cd14499
    Location:199372
    CDC14_C; C-terminal dual-specificity phosphatase domain of CDC14 family proteins
    cd17657
    Location:52190
    CDC14_N; N-terminal domain pseudophosphatase domain of CDC14 family proteins
  6. XM_006517227.4XP_006517290.1  dual specificity protein phosphatase CDC14B isoform X10

    Conserved Domains (2) summary
    cd14499
    Location:162335
    CDC14_C; C-terminal dual-specificity phosphatase domain of CDC14 family proteins
    pfam14671
    Location:13151
    DSPn; Dual specificity protein phosphatase, N-terminal half
  7. XM_036157999.1XP_036013892.1  dual specificity protein phosphatase CDC14B isoform X4

    Conserved Domains (2) summary
    cd14499
    Location:199372
    CDC14_C; C-terminal dual-specificity phosphatase domain of CDC14 family proteins
    cd17657
    Location:52190
    CDC14_N; N-terminal domain pseudophosphatase domain of CDC14 family proteins
  8. XM_036158006.1XP_036013899.1  dual specificity protein phosphatase CDC14B isoform X13

    Conserved Domains (1) summary
    cd14499
    Location:10183
    CDC14_C; C-terminal dual-specificity phosphatase domain of CDC14 family proteins
  9. XM_006517229.3XP_006517292.1  dual specificity protein phosphatase CDC14B isoform X12

    Conserved Domains (1) summary
    cd14499
    Location:10183
    CDC14_C; C-terminal dual-specificity phosphatase domain of CDC14 family proteins
  10. XM_006517219.1XP_006517282.1  dual specificity protein phosphatase CDC14B isoform X2

    Conserved Domains (2) summary
    cd14499
    Location:162335
    CDC14_C; C-terminal dual-specificity phosphatase domain of CDC14 family proteins
    pfam14671
    Location:13151
    DSPn; Dual specificity protein phosphatase, N-terminal half
  11. XM_011244515.4XP_011242817.1  dual specificity protein phosphatase CDC14B isoform X9

    Conserved Domains (2) summary
    cd14499
    Location:104277
    CDC14_C; C-terminal dual-specificity phosphatase domain of CDC14 family proteins
    pfam14671
    Location:193
    DSPn; Dual specificity protein phosphatase, N-terminal half
  12. XM_036158003.1XP_036013896.1  dual specificity protein phosphatase CDC14B isoform X7

    UniProtKB/Swiss-Prot
    Q8BLV5
    Conserved Domains (2) summary
    cd14499
    Location:199372
    CDC14_C; C-terminal dual-specificity phosphatase domain of CDC14 family proteins
    cd17657
    Location:52190
    CDC14_N; N-terminal domain pseudophosphatase domain of CDC14 family proteins
  13. XM_036158004.1XP_036013897.1  dual specificity protein phosphatase CDC14B isoform X8

    Conserved Domains (2) summary
    cd14499
    Location:199372
    CDC14_C; C-terminal dual-specificity phosphatase domain of CDC14 family proteins
    cd17657
    Location:52190
    CDC14_N; N-terminal domain pseudophosphatase domain of CDC14 family proteins
  14. XM_036158002.1XP_036013895.1  dual specificity protein phosphatase CDC14B isoform X7

    UniProtKB/Swiss-Prot
    Q8BLV5
    Conserved Domains (2) summary
    cd14499
    Location:199372
    CDC14_C; C-terminal dual-specificity phosphatase domain of CDC14 family proteins
    cd17657
    Location:52190
    CDC14_N; N-terminal domain pseudophosphatase domain of CDC14 family proteins

RNA

  1. XR_004938019.1 RNA Sequence

  2. XR_004938022.1 RNA Sequence

  3. XR_004938021.1 RNA Sequence

  4. XR_873438.3 RNA Sequence

  5. XR_004938020.1 RNA Sequence