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Thbs1 thrombospondin 1 [ Mus musculus (house mouse) ]

Gene ID: 21825, updated on 27-Feb-2024

Summary

Official Symbol
Thbs1provided by MGI
Official Full Name
thrombospondin 1provided by MGI
Primary source
MGI:MGI:98737
See related
Ensembl:ENSMUSG00000040152 AllianceGenome:MGI:98737
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
TSP1; TSP-1; tbsp1; Thbs-1
Summary
The protein encoded by this gene is a subunit of a disulfide-linked homotrimeric protein. This protein is an adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. This protein can bind to fibrinogen, fibronectin, laminin, type V collagen and integrins alpha-V/beta-1. This protein has been shown to play roles in platelet aggregation, angiogenesis, and tumorigenesis. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2015]
Expression
Broad expression in ovary adult (RPKM 32.7), limb E14.5 (RPKM 32.4) and 21 other tissues See more
Orthologs
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Genomic context

See Thbs1 in Genome Data Viewer
Location:
2 E5; 2 59.34 cM
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (117942357..117957614)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (118111876..118127133)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene predicted gene 13986 Neighboring gene STARR-seq mESC enhancer starr_05455 Neighboring gene DEAD (Asp-Glu-Ala-Asp) box polypeptide 18 pseudogene Neighboring gene STARR-positive B cell enhancer mm9_chr2:117936762-117937062 Neighboring gene predicted gene, 25308 Neighboring gene STARR-seq mESC enhancer starr_05456 Neighboring gene fibrous sheath-interacting protein 1 Neighboring gene STARR-positive B cell enhancer ABC_E7849 Neighboring gene STARR-positive B cell enhancer mm9_chr2:118089004-118089305 Neighboring gene STARR-seq mESC enhancer starr_05457 Neighboring gene RIKEN cDNA 1700054M17 gene Neighboring gene STARR-seq mESC enhancer starr_05459 Neighboring gene G protein-coupled receptor 176

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 
enables collagen V binding ISO
Inferred from Sequence Orthology
more info
 
enables endopeptidase inhibitor activity ISO
Inferred from Sequence Orthology
more info
 
enables extracellular matrix binding IDA
Inferred from Direct Assay
more info
PubMed 
enables extracellular matrix structural constituent RCA
inferred from Reviewed Computational Analysis
more info
PubMed 
enables fibrinogen binding ISO
Inferred from Sequence Orthology
more info
 
enables fibroblast growth factor binding ISO
Inferred from Sequence Orthology
more info
 
enables fibronectin binding ISO
Inferred from Sequence Orthology
more info
 
enables heparin binding ISO
Inferred from Sequence Orthology
more info
PubMed 
enables integrin binding ISO
Inferred from Sequence Orthology
more info
 
enables laminin binding ISO
Inferred from Sequence Orthology
more info
 
enables low-density lipoprotein particle binding ISO
Inferred from Sequence Orthology
more info
 
enables phosphatidylserine binding ISO
Inferred from Sequence Orthology
more info
 
enables protease binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
enables transforming growth factor beta binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within angiogenesis IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within apoptotic process IEA
Inferred from Electronic Annotation
more info
 
involved_in behavioral response to pain IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within blood vessel morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within cell adhesion IEA
Inferred from Electronic Annotation
more info
 
involved_in cell adhesion IEA
Inferred from Electronic Annotation
more info
 
involved_in cell migration ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cellular response to nitric oxide IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within endocardial cushion development IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in engulfment of apoptotic cell ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within growth plate cartilage development IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within growth plate cartilage development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within inflammatory response IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in inflammatory response ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within monocyte aggregation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of angiogenesis IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within negative regulation of angiogenesis IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within negative regulation of angiogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of angiogenesis ISO
Inferred from Sequence Orthology
more info
PubMed 
involved_in negative regulation of angiogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of blood vessel endothelial cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cGMP-mediated signaling ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cell migration involved in sprouting angiogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of cell-matrix adhesion ISO
Inferred from Sequence Orthology
more info
PubMed 
involved_in negative regulation of cell-matrix adhesion ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cysteine-type endopeptidase activity involved in apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of dendritic cell antigen processing and presentation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of endothelial cell chemotaxis ISO
Inferred from Sequence Orthology
more info
PubMed 
involved_in negative regulation of endothelial cell migration ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of endothelial cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of endothelial cell proliferation ISO
Inferred from Sequence Orthology
more info
PubMed 
involved_in negative regulation of endothelial cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of fibrinolysis ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of fibroblast growth factor receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of interleukin-12 production ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of long-chain fatty acid import across plasma membrane ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of nitric oxide mediated signal transduction ISO
Inferred from Sequence Orthology
more info
PubMed 
involved_in negative regulation of nitric oxide mediated signal transduction ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of plasminogen activation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of sprouting angiogenesis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within outflow tract morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in peptide cross-linking ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of positive regulation of MAP kinase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of angiogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of blood coagulation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of blood vessel endothelial cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of cell-substrate adhesion IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of chemotaxis ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of endothelial cell apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of endothelial cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of extrinsic apoptotic signaling pathway via death domain receptors ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of fibroblast migration ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of macrophage activation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of macrophage chemotaxis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of reactive oxygen species metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of smooth muscle cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of transforming growth factor beta production ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of transforming growth factor beta receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of transforming growth factor beta receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of translation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of tumor necrosis factor production ISO
Inferred from Sequence Orthology
more info
 
involved_in response to calcium ion ISO
Inferred from Sequence Orthology
more info
 
involved_in response to endoplasmic reticulum stress IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to glucose ISO
Inferred from Sequence Orthology
more info
 
involved_in response to magnesium ion ISO
Inferred from Sequence Orthology
more info
 
involved_in response to mechanical stimulus ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within response to unfolded protein IEA
Inferred from Electronic Annotation
more info
 
involved_in sprouting angiogenesis ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in cell surface ISO
Inferred from Sequence Orthology
more info
 
located_in collagen-containing extracellular matrix HDA PubMed 
is_active_in collagen-containing extracellular matrix IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
located_in external side of plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in extracellular matrix ISO
Inferred from Sequence Orthology
more info
 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
located_in extracellular space HDA PubMed 
located_in extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
 
part_of fibrinogen complex ISO
Inferred from Sequence Orthology
more info
 
located_in platelet alpha granule ISO
Inferred from Sequence Orthology
more info
 
located_in sarcoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
located_in secretory granule ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
thrombospondin-1
Names
glycoprotein G

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001313914.1NP_001300843.1  thrombospondin-1 isoform 2 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AK163092, AL845495, AL928957, BC050917
    UniProtKB/Swiss-Prot
    P35441
    UniProtKB/TrEMBL
    Q3TR40
    Conserved Domains (10) summary
    smart00209
    Location:438490
    TSP1; Thrombospondin type 1 repeats
    sd00001
    Location:845882
    TSP3; TSP3 repeat_long [structural motif]
    sd00002
    Location:787821
    TSP3; TSP3 repeat_long [structural motif]
    sd00003
    Location:691726
    TSP3_1C; TSP3 repeat_1C [structural motif]
    pfam00090
    Location:383428
    TSP_1; Thrombospondin type 1 domain
    pfam00093
    Location:318372
    VWC; von Willebrand factor type C domain
    pfam02412
    Location:846882
    TSP_3; Thrombospondin type 3 repeat
    pfam05735
    Location:9721169
    TSP_C; Thrombospondin C-terminal region
    pfam12947
    Location:650689
    EGF_3; EGF domain
    cl22861
    Location:26221
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
  2. NM_011580.4NP_035710.2  thrombospondin-1 isoform 1 precursor

    See identical proteins and their annotated locations for NP_035710.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK163092, AL845495, AL928957, BC050917
    Consensus CDS
    CCDS38200.1
    UniProtKB/TrEMBL
    Q80YQ1, Q8CGB2
    Related
    ENSMUSP00000044903.9, ENSMUST00000039559.9
    Conserved Domains (10) summary
    smart00209
    Location:439491
    TSP1; Thrombospondin type 1 repeats
    sd00001
    Location:846883
    TSP3; TSP3 repeat_long [structural motif]
    sd00002
    Location:788822
    TSP3; TSP3 repeat_long [structural motif]
    sd00003
    Location:692727
    TSP3_1C; TSP3 repeat_1C [structural motif]
    pfam00090
    Location:384429
    TSP_1; Thrombospondin type 1 domain
    pfam00093
    Location:319373
    VWC; von Willebrand factor type C domain
    pfam02412
    Location:847883
    TSP_3; Thrombospondin type 3 repeat
    pfam05735
    Location:9731170
    TSP_C; Thrombospondin C-terminal region
    pfam12947
    Location:651690
    EGF_3; EGF domain
    cl22861
    Location:26221
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    117942357..117957614
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)