U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Th tyrosine hydroxylase [ Mus musculus (house mouse) ]

Gene ID: 21823, updated on 11-Aug-2022

Summary

Official Symbol
Thprovided by MGI
Official Full Name
tyrosine hydroxylaseprovided by MGI
Primary source
MGI:MGI:98735
See related
Ensembl:ENSMUSG00000000214 AllianceGenome:MGI:98735
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to enable several functions, including cation binding activity; tetrahydrobiopterin binding activity; and tyrosine 3-monooxygenase activity. Involved in eye development and visual perception. Acts upstream of or within several processes, including dopamine biosynthetic process from tyrosine; dopaminergic synaptic transmission; and learning or memory. Located in several cellular components, including axon; perikaryon; and perinuclear region of cytoplasm. Is expressed in several structures, including alimentary system; cardiovascular system; eye; genitourinary system; and nervous system. Human ortholog(s) of this gene implicated in Parkinson's disease; Parkinsonism; hypertension; and obesity. Orthologous to human TH (tyrosine hydroxylase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in adrenal adult (RPKM 216.0) and frontal lobe adult (RPKM 33.7) See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Location:
7 F5; 7 88.06 cM
Exon count:
13
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (142446516..142453732, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (142892779..142899995, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 7 NC_000073.5 (150078681..150085871, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene ribosomal protein L13 pseudogene Neighboring gene predicted gene 6471 Neighboring gene predicted gene, 39117 Neighboring gene achaete-scute family bHLH transcription factor 2 Neighboring gene tetraspanin 32

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (20)  1 citation
  • Endonuclease-mediated (6) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables amino acid binding ISO
Inferred from Sequence Orthology
more info
 
enables dopamine binding ISO
Inferred from Sequence Orthology
more info
 
enables enzyme binding ISO
Inferred from Sequence Orthology
more info
 
enables ferric iron binding ISO
Inferred from Sequence Orthology
more info
 
enables ferrous iron binding ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables iron ion binding IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables monooxygenase activity ISO
Inferred from Sequence Orthology
more info
 
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
 
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen IEA
Inferred from Electronic Annotation
more info
 
enables oxygen binding ISO
Inferred from Sequence Orthology
more info
 
enables protein domain specific binding ISO
Inferred from Sequence Orthology
more info
 
enables tetrahydrobiopterin binding ISO
Inferred from Sequence Orthology
more info
 
enables tyrosine 3-monooxygenase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables tyrosine 3-monooxygenase activity ISO
Inferred from Sequence Orthology
more info
 
enables tyrosine 3-monooxygenase activity TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
involved_in aminergic neurotransmitter loading into synaptic vesicle ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within animal organ morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in aromatic amino acid family metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in catecholamine biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in dopamine biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in dopamine biosynthetic process from tyrosine IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within dopamine biosynthetic process from tyrosine IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within dopamine biosynthetic process from tyrosine IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in dopamine biosynthetic process from tyrosine ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within dopamine biosynthetic process from tyrosine TAS
Traceable Author Statement
more info
PubMed 
acts_upstream_of_or_within eating behavior IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within eating behavior IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in embryonic camera-type eye morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in epinephrine biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in eye photoreceptor cell development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in heart development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within heart development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in heart development ISO
Inferred from Sequence Orthology
more info
 
involved_in hyaloid vascular plexus regression IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within learning IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within locomotory behavior IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within locomotory behavior IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within mating behavior IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within memory IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within neurotransmitter biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
involved_in norepinephrine biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of heart contraction IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to ethanol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in response to ethanol ISO
Inferred from Sequence Orthology
more info
 
involved_in response to hypoxia IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in response to hypoxia ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within synaptic transmission, dopaminergic IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in visual perception IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
is_active_in axon IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in axon IDA
Inferred from Direct Assay
more info
PubMed 
located_in axon ISO
Inferred from Sequence Orthology
more info
 
located_in cell projection IEA
Inferred from Electronic Annotation
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasmic side of plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasmic vesicle ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasmic vesicle membrane ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in dendrite ISO
Inferred from Sequence Orthology
more info
 
located_in melanosome membrane ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 
located_in neuron projection IDA
Inferred from Direct Assay
more info
PubMed 
located_in neuron projection ISO
Inferred from Sequence Orthology
more info
 
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
is_active_in perikaryon IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in perikaryon IDA
Inferred from Direct Assay
more info
PubMed 
located_in perikaryon ISO
Inferred from Sequence Orthology
more info
 
located_in perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in smooth endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
located_in synaptic vesicle ISO
Inferred from Sequence Orthology
more info
 
located_in terminal bouton ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
tyrosine 3-monooxygenase
Names
tyrosine 3-hydroxylase
NP_033403.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_009377.2NP_033403.1  tyrosine 3-monooxygenase

    See identical proteins and their annotated locations for NP_033403.1

    Status: VALIDATED

    Source sequence(s)
    AK139568, BB868869, CJ194802
    Consensus CDS
    CCDS22036.1
    UniProtKB/Swiss-Prot
    P24529
    Related
    ENSMUSP00000000219.4, ENSMUST00000000219.10
    Conserved Domains (4) summary
    TIGR01269
    Location:38495
    Tyr_3_monoox; tyrosine 3-monooxygenase, tetrameric
    cd04930
    Location:38158
    ACT_TH; ACT domain of the nonheme iron-dependent aromatic amino acid hydroxylase, tyrosine hydroxylases (TH)
    pfam00351
    Location:165495
    Biopterin_H; Biopterin-dependent aromatic amino acid hydroxylase
    pfam12549
    Location:226
    TOH_N; Tyrosine hydroxylase N terminal

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    142446516..142453732 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)