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Th tyrosine hydroxylase [ Mus musculus (house mouse) ]

Gene ID: 21823, updated on 7-Aug-2018
Official Symbol
Thprovided by MGI
Official Full Name
tyrosine hydroxylaseprovided by MGI
Primary source
MGI:MGI:98735
See related
Ensembl:ENSMUSG00000000214 Vega:OTTMUSG00000018790
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Expression
Biased expression in adrenal adult (RPKM 216.0) and frontal lobe adult (RPKM 33.7) See more
Orthologs
Location:
7 F5; 7 88.06 cM
Exon count:
13
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 7 NC_000073.6 (142892776..142899966, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 7 NC_000073.5 (150078681..150085871, complement)

Chromosome 7 - NC_000073.6Genomic Context describing neighboring genes Neighboring gene ribosomal protein L13 pseudogene Neighboring gene predicted gene, 39117 Neighboring gene achaete-scute family bHLH transcription factor 2 Neighboring gene tetraspanin 32 Neighboring gene expressed sequence R74862 Neighboring gene CD81 antigen

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (19)  1 citation
  • Endonuclease-mediated (1) 

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
amino acid binding ISO
Inferred from Sequence Orthology
more info
 
dopamine binding ISO
Inferred from Sequence Orthology
more info
 
enzyme binding ISO
Inferred from Sequence Orthology
more info
 
ferric iron binding ISO
Inferred from Sequence Orthology
more info
 
ferrous iron binding ISO
Inferred from Sequence Orthology
more info
 
iron ion binding IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
monooxygenase activity ISO
Inferred from Sequence Orthology
more info
 
oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
 
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen IEA
Inferred from Electronic Annotation
more info
 
oxygen binding ISO
Inferred from Sequence Orthology
more info
 
protein domain specific binding ISO
Inferred from Sequence Orthology
more info
 
tetrahydrobiopterin binding ISO
Inferred from Sequence Orthology
more info
 
tyrosine 3-monooxygenase activity ISO
Inferred from Sequence Orthology
more info
 
tyrosine 3-monooxygenase activity TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
aminergic neurotransmitter loading into synaptic vesicle ISO
Inferred from Sequence Orthology
more info
 
animal organ morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
aromatic amino acid family metabolic process IEA
Inferred from Electronic Annotation
more info
 
catecholamine biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
dopamine biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
dopamine biosynthetic process from tyrosine IDA
Inferred from Direct Assay
more info
PubMed 
dopamine biosynthetic process from tyrosine IMP
Inferred from Mutant Phenotype
more info
PubMed 
dopamine biosynthetic process from tyrosine ISO
Inferred from Sequence Orthology
more info
 
dopamine biosynthetic process from tyrosine TAS
Traceable Author Statement
more info
PubMed 
eating behavior IGI
Inferred from Genetic Interaction
more info
PubMed 
eating behavior IMP
Inferred from Mutant Phenotype
more info
PubMed 
embryonic camera-type eye morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
epinephrine biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
eye photoreceptor cell development IMP
Inferred from Mutant Phenotype
more info
PubMed 
heart development IMP
Inferred from Mutant Phenotype
more info
PubMed 
heart development ISO
Inferred from Sequence Orthology
more info
 
learning IMP
Inferred from Mutant Phenotype
more info
PubMed 
locomotory behavior IGI
Inferred from Genetic Interaction
more info
PubMed 
locomotory behavior IMP
Inferred from Mutant Phenotype
more info
PubMed 
mating behavior IMP
Inferred from Mutant Phenotype
more info
PubMed 
memory IMP
Inferred from Mutant Phenotype
more info
PubMed 
neurotransmitter biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
norepinephrine biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
oxidation-reduction process IEA
Inferred from Electronic Annotation
more info
 
regulation of heart contraction IMP
Inferred from Mutant Phenotype
more info
PubMed 
response to ethanol ISO
Inferred from Sequence Orthology
more info
 
response to hypoxia ISO
Inferred from Sequence Orthology
more info
 
synaptic transmission, dopaminergic IMP
Inferred from Mutant Phenotype
more info
PubMed 
visual perception IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
axon IDA
Inferred from Direct Assay
more info
PubMed 
axon ISO
Inferred from Sequence Orthology
more info
 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
cytoplasmic side of plasma membrane ISO
Inferred from Sequence Orthology
more info
 
cytoplasmic vesicle ISO
Inferred from Sequence Orthology
more info
 
cytoplasmic vesicle membrane ISO
Inferred from Sequence Orthology
more info
 
cytosol ISO
Inferred from Sequence Orthology
more info
 
dendrite ISO
Inferred from Sequence Orthology
more info
 
melanosome membrane ISO
Inferred from Sequence Orthology
more info
 
mitochondrion ISO
Inferred from Sequence Orthology
more info
 
neuron projection IDA
Inferred from Direct Assay
more info
PubMed 
neuron projection ISO
Inferred from Sequence Orthology
more info
 
neuronal cell body ISO
Inferred from Sequence Orthology
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
perikaryon IDA
Inferred from Direct Assay
more info
PubMed 
perikaryon ISO
Inferred from Sequence Orthology
more info
 
smooth endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
synaptic vesicle ISO
Inferred from Sequence Orthology
more info
 
terminal bouton ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
tyrosine 3-monooxygenase
Names
tyrosine 3-hydroxylase
NP_033403.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_009377.2NP_033403.1  tyrosine 3-monooxygenase

    See identical proteins and their annotated locations for NP_033403.1

    Status: VALIDATED

    Source sequence(s)
    AK139568, BB868869, CJ194802
    Consensus CDS
    CCDS22036.1
    UniProtKB/Swiss-Prot
    P24529
    Related
    ENSMUSP00000000219.3, OTTMUSP00000020341, ENSMUST00000000219.9
    Conserved Domains (4) summary
    TIGR01269
    Location:38495
    Tyr_3_monoox; tyrosine 3-monooxygenase, tetrameric
    cd04930
    Location:38158
    ACT_TH; ACT domain of the nonheme iron-dependent aromatic amino acid hydroxylase, tyrosine hydroxylases (TH)
    pfam00351
    Location:165495
    Biopterin_H; Biopterin-dependent aromatic amino acid hydroxylase
    pfam12549
    Location:226
    TOH_N; Tyrosine hydroxylase N terminal

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000073.6 Reference GRCm38.p4 C57BL/6J

    Range
    142892776..142899966 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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