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Tg thyroglobulin [ Mus musculus (house mouse) ]

Gene ID: 21819, updated on 5-Jan-2022

Summary

Official Symbol
Tgprovided by MGI
Official Full Name
thyroglobulinprovided by MGI
Primary source
MGI:MGI:98733
See related
Ensembl:ENSMUSG00000053469
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Tgn; cog
Summary
Enables identical protein binding activity. Involved in thyroid hormone generation. Acts upstream of or within iodide transport; regulation of myelination; and thyroid hormone metabolic process. Located in extracellular space. Is expressed in thyroid gland; thyroid gland follicle; thyroid gland left lobe colloid-filled follicles; thyroid gland lobe; and thyroid gland right lobe colloid-filled follicles. Used to study congenital hypothyroidism. Human ortholog(s) of this gene implicated in Graves' disease; autoimmune thyroiditis; goiter; and thyroid dyshormonogenesis 3. Orthologous to human TG (thyroglobulin). [provided by Alliance of Genome Resources, Nov 2021]
Expression
Biased expression in testis adult (RPKM 1.0), genital fat pad adult (RPKM 0.3) and 10 other tissues See more
Orthologs
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Genomic context

Location:
15 D2; 15 29.3 cM
Exon count:
49
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (66542606..66722570)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (66670754..66850721)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 15 NC_000081.5 (66502332..66682283)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene transmembrane protein 71 Neighboring gene PHD finger protein 20-like 1 Neighboring gene VISTA enhancer mm104 Neighboring gene src-like adaptor Neighboring gene predicted gene, 46514 Neighboring gene cellular communication network factor 4

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Spontaneous (1) 
  • Chemically induced (ENU) (7)  1 citation
  • Endonuclease-mediated (1) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC117699

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables anion binding ISO
Inferred from Sequence Orthology
more info
 
enables chaperone binding ISO
Inferred from Sequence Orthology
more info
 
enables hormone activity IEA
Inferred from Electronic Annotation
more info
 
enables identical protein binding IDA
Inferred from Direct Assay
more info
PubMed 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
 
enables signaling receptor binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within hormone biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within iodide transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of myelination IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to pH ISO
Inferred from Sequence Orthology
more info
 
involved_in thyroid hormone generation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in thyroid hormone generation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in thyroid hormone generation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within thyroid hormone metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in transcytosis ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
 
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
 
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
thyroglobulin
Names
congenital goiter

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_009375.2NP_033401.2  thyroglobulin precursor

    See identical proteins and their annotated locations for NP_033401.2

    Status: VALIDATED

    Source sequence(s)
    BC111467, CK788949, CK789624, U76389
    Consensus CDS
    CCDS37091.1
    UniProtKB/Swiss-Prot
    O08710
    Related
    ENSMUSP00000070239.8, ENSMUST00000065916.14
    Conserved Domains (5) summary
    smart00211
    Location:15191566
    TY; Thyroglobulin type I repeats
    cd00191
    Location:96161
    TY; Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases
    pfam00135
    Location:21922717
    COesterase; Carboxylesterase family
    pfam07699
    Location:14641509
    GCC2_GCC3; GCC2 and GCC3
    cl00150
    Location:893922
    TY; Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    66542606..66722570
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006520745.4XP_006520808.2  thyroglobulin isoform X1

    Conserved Domains (5) summary
    smart00211
    Location:15191566
    TY; Thyroglobulin type I repeats
    cd00191
    Location:96161
    TY; Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases
    pfam07699
    Location:14641509
    Ephrin_rec_like; Putative ephrin-receptor like
    pfam00135
    Location:21982717
    COesterase; Carboxylesterase family
    cl00150
    Location:893922
    TY; Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases

RNA

  1. XR_004938813.1 RNA Sequence

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