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Tgfbr2 transforming growth factor, beta receptor II [ Mus musculus (house mouse) ]

Gene ID: 21813, updated on 30-Nov-2021

Summary

Official Symbol
Tgfbr2provided by MGI
Official Full Name
transforming growth factor, beta receptor IIprovided by MGI
Primary source
MGI:MGI:98729
See related
Ensembl:ENSMUSG00000032440
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
DNIIR; RIIDN; TBR-II; AU042018; TbetaRII; TbetaR-II; 1110020H15Rik
Expression
Broad expression in lung adult (RPKM 56.6), subcutaneous fat pad adult (RPKM 56.5) and 23 other tissues See more
Orthologs
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Genomic context

See Tgfbr2 in Genome Data Viewer
Location:
9 F3; 9 68.39 cM
Exon count:
8
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (115916763..116004431, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (116087695..116175363, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 9 NC_000075.5 (115996813..116084481, complement)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene glutamate decarboxylase-like 1 Neighboring gene predicted gene, 31014 Neighboring gene vaccinia related kinase 1 pseudogene Neighboring gene predicted gene, 31292 Neighboring gene predicted gene, 40582 Neighboring gene predicted gene 4668 Neighboring gene Tgfbr2 Hedgehog-responsive enhancer Neighboring gene predicted gene, 31410

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (10)  1 citation
  • Endonuclease-mediated (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables SMAD binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables SMAD binding IDA
Inferred from Direct Assay
more info
PubMed 
enables SMAD binding ISO
Inferred from Sequence Orthology
more info
 
enables activin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables activin-activated receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables glycosaminoglycan binding ISO
Inferred from Sequence Orthology
more info
 
enables kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables mitogen-activated protein kinase kinase kinase binding ISO
Inferred from Sequence Orthology
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables signaling receptor activity IEA
Inferred from Electronic Annotation
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
enables transforming growth factor beta binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables transforming growth factor beta binding IPI
Inferred from Physical Interaction
more info
PubMed 
contributes_to transforming growth factor beta binding ISO
Inferred from Sequence Orthology
more info
 
enables transforming growth factor beta binding ISO
Inferred from Sequence Orthology
more info
 
enables transforming growth factor beta receptor activity, type II ISO
Inferred from Sequence Orthology
more info
 
enables transforming growth factor beta-activated receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables transforming growth factor beta-activated receptor activity IGI
Inferred from Genetic Interaction
more info
PubMed 
enables transforming growth factor beta-activated receptor activity ISO
Inferred from Sequence Orthology
more info
 
enables transmembrane receptor protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables type I transforming growth factor beta receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables type I transforming growth factor beta receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables type III transforming growth factor beta receptor binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within Notch signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within activation of protein kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
involved_in animal organ morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in atrioventricular valve morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in brain development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within branching involved in blood vessel morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within bronchus development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within bronchus morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cardiac left ventricle morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cartilage development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cell differentiation IEA
Inferred from Electronic Annotation
more info
 
NOT involved_in cell proliferation involved in endocardial cushion morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular response to growth factor stimulus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in common-partner SMAD protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in embryonic cranial skeleton morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in embryonic hemopoiesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in endocardial cushion fusion IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within gastrulation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within growth plate cartilage chondrocyte growth IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within growth plate cartilage development IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in heart development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within heart development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in heart looping IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within in utero embryonic development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in inferior endocardial cushion morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within lens development in camera-type eye IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within lens fiber cell apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within lung development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within lung lobe morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within lung morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within mammary gland morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in membranous septum morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in miRNA transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within myeloid dendritic cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of cardiac muscle cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in outflow tract morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in outflow tract septum morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in pathway-restricted SMAD protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in peptidyl-serine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in peptidyl-threonine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within positive regulation of B cell tolerance induction IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of CD4-positive, alpha-beta T cell proliferation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of NK T cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of T cell tolerance induction IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of angiogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within positive regulation of epithelial cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of epithelial to mesenchymal transition ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of mesenchymal cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of pathway-restricted SMAD protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of reactive oxygen species metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of smooth muscle cell proliferation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of tolerance induction to self antigen IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within protein phosphorylation TAS
Traceable Author Statement
more info
PubMed 
involved_in receptor-mediated endocytosis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of cell population proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of growth IEA
Inferred from Electronic Annotation
more info
 
involved_in response to cholesterol IDA
Inferred from Direct Assay
more info
PubMed 
involved_in response to cholesterol ISO
Inferred from Sequence Orthology
more info
 
involved_in response to xenobiotic stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in secondary palate development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within smoothened signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
NOT involved_in superior endocardial cushion morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within trachea formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within trachea morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in transforming growth factor beta receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within transforming growth factor beta receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in transforming growth factor beta receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in transmembrane receptor protein serine/threonine kinase signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in tricuspid valve morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in vasculogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in ventricular septum morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in caveola ISO
Inferred from Sequence Orthology
more info
PubMed 
located_in cell surface ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in external side of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in external side of plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in integral component of membrane ISO
Inferred from Sequence Orthology
more info
 
located_in integral component of plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in membrane raft ISO
Inferred from Sequence Orthology
more info
PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
part_of receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of receptor complex ISO
Inferred from Sequence Orthology
more info
 
part_of transforming growth factor beta ligand-receptor complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
TGF-beta receptor type-2
Names
TGF-beta receptor II
TGF-beta receptor type II
TGF-beta type II receptor
TGFR-2
transforming growth factor-beta receptor type II
NP_033397.3
NP_083851.3

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_009371.3NP_033397.3  TGF-beta receptor type-2 isoform 1 precursor

    See identical proteins and their annotated locations for NP_033397.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK046561, AK053793, CO039384
    Consensus CDS
    CCDS23601.1
    UniProtKB/Swiss-Prot
    Q62312
    UniProtKB/TrEMBL
    Q543C0, Q8BQS9
    Related
    ENSMUSP00000062333.5, ENSMUST00000061101.12
    Conserved Domains (3) summary
    smart00221
    Location:269566
    STYKc; Protein kinase; unclassified specificity
    cd14055
    Location:273567
    STKc_TGFbR2_like; Catalytic domain of the Serine/Threonine Kinase, Transforming Growth Factor beta Type II Receptor
    pfam08917
    Location:74177
    ecTbetaR2; Transforming growth factor beta receptor 2 ectodomain
  2. NM_029575.3NP_083851.3  TGF-beta receptor type-2 isoform 2 precursor

    See identical proteins and their annotated locations for NP_083851.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AK046561, AK053793, AK148167, CO039384
    Consensus CDS
    CCDS23602.1
    UniProtKB/TrEMBL
    Q3UG22, Q543C0, Q8BQS9
    Related
    ENSMUSP00000035014.7, ENSMUST00000035014.8
    Conserved Domains (2) summary
    cd14055
    Location:248542
    STKc_TGFbR2_like; Catalytic domain of the Serine/Threonine Kinase, Transforming Growth Factor beta Type II Receptor
    pfam08917
    Location:49159
    ecTbetaR2; Transforming growth factor beta receptor 2 ectodomain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    115916763..116004431 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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