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ACSL3 acyl-CoA synthetase long chain family member 3 [ Homo sapiens (human) ]

Gene ID: 2181, updated on 6-Sep-2021

Summary

Official Symbol
ACSL3provided by HGNC
Official Full Name
acyl-CoA synthetase long chain family member 3provided by HGNC
Primary source
HGNC:HGNC:3570
See related
Ensembl:ENSG00000123983 MIM:602371
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ACS3; FACL3; LACS3; LACS 3; PRO2194
Summary
The protein encoded by this gene is an isozyme of the long-chain fatty-acid-coenzyme A ligase family. Although differing in substrate specificity, subcellular localization, and tissue distribution, all isozymes of this family convert free long-chain fatty acids into fatty acyl-CoA esters, and thereby play a key role in lipid biosynthesis and fatty acid degradation. This isozyme is highly expressed in brain, and preferentially utilizes myristate, arachidonate, and eicosapentaenoate as substrates. The amino acid sequence of this isozyme is 92% identical to that of rat homolog. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in prostate (RPKM 44.8), brain (RPKM 31.0) and 24 other tissues See more
Orthologs
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Genomic context

See ACSL3 in Genome Data Viewer
Location:
2q36.1
Exon count:
17
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (222861036..222944639)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (223725754..223809357)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105373903 Neighboring gene ribosomal protein L31 pseudogene 17 Neighboring gene Sharpr-MPRA regulatory region 9896 Neighboring gene autophagy related 12 pseudogene 2 Neighboring gene ACSL3 antisense RNA 1 Neighboring gene zinc finger protein 79 pseudogene Neighboring gene potassium voltage-gated channel subfamily E regulatory subunit 4

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env Tandem affinity purification and mass spectrometry analysis identify acyl-CoA synthetase long-chain family member 3 (ACSL3), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Gag-Pol gag-pol Tandem affinity purification and mass spectrometry analysis identify acyl-CoA synthetase long-chain family member 3 (ACSL3), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Nef nef Tandem affinity purification and mass spectrometry analysis identify acyl-CoA synthetase long-chain family member 3 (ACSL3), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Pr55(Gag) gag Tandem affinity purification and mass spectrometry analysis identify acyl-CoA synthetase long-chain family member 3 (ACSL3), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Vpu vpu HIV-1 Vpu is identified to have a physical interaction with acyl-CoA synthetase long-chain family member 3 (ACSL3) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables arachidonate-CoA ligase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables long-chain fatty acid-CoA ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables long-chain fatty acid-CoA ligase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables long-chain fatty acid-CoA ligase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables long-chain fatty acid-CoA ligase activity TAS
Traceable Author Statement
more info
 
enables palmitoyl-CoA ligase activity TAS
Traceable Author Statement
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein domain specific binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in brain development IEA
Inferred from Electronic Annotation
more info
 
involved_in fatty acid biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
involved_in fatty acid metabolic process TAS
Traceable Author Statement
more info
 
acts_upstream_of long-chain fatty acid import into cell IDA
Inferred from Direct Assay
more info
PubMed 
involved_in long-chain fatty acid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in long-chain fatty acid metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in long-chain fatty acid metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in long-chain fatty-acyl-CoA biosynthetic process TAS
Traceable Author Statement
more info
 
involved_in long-chain fatty-acyl-CoA metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in neuron differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of Golgi to plasma membrane protein transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of phosphatidylcholine biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to nutrient IEA
Inferred from Electronic Annotation
more info
 
involved_in response to organic cyclic compound IEA
Inferred from Electronic Annotation
more info
 
involved_in very-low-density lipoprotein particle assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
located_in endoplasmic reticulum membrane TAS
Traceable Author Statement
more info
 
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in lipid droplet IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in lipid droplet IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane HDA PubMed 
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in mitochondrial outer membrane TAS
Traceable Author Statement
more info
 
located_in perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in peroxisomal membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
long-chain-fatty-acid--CoA ligase 3
Names
arachidonate--CoA ligase
fatty-acid-Coenzyme A ligase, long-chain 3
lignoceroyl-CoA synthase
long-chain acyl-CoA synthetase 3
NP_001341087.1
NP_001341088.1
NP_004448.2
NP_976251.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001354158.2NP_001341087.1  long-chain-fatty-acid--CoA ligase 3

    Status: REVIEWED

    Source sequence(s)
    AC013476, AC016712
    Consensus CDS
    CCDS2455.1
    Related
    ENSP00000505793.1, ENST00000680395.1
    Conserved Domains (1) summary
    cl17068
    Location:30717
    AFD_class_I; Adenylate forming domain, Class I superfamily
  2. NM_001354159.2NP_001341088.1  long-chain-fatty-acid--CoA ligase 3

    Status: REVIEWED

    Source sequence(s)
    AC013476, AC016712
    Consensus CDS
    CCDS2455.1
    Related
    ENSP00000505400.1, ENST00000680251.1
    Conserved Domains (1) summary
    cl17068
    Location:30717
    AFD_class_I; Adenylate forming domain, Class I superfamily
  3. NM_004457.5NP_004448.2  long-chain-fatty-acid--CoA ligase 3

    See identical proteins and their annotated locations for NP_004448.2

    Status: REVIEWED

    Source sequence(s)
    AC013476, BC041692
    Consensus CDS
    CCDS2455.1
    UniProtKB/Swiss-Prot
    O95573
    UniProtKB/TrEMBL
    A0A024R497
    Related
    ENSP00000350012.3, ENST00000357430.8
    Conserved Domains (1) summary
    cl17068
    Location:30717
    AFD_class_I; Adenylate forming domain, Class I superfamily
  4. NM_203372.3NP_976251.1  long-chain-fatty-acid--CoA ligase 3

    See identical proteins and their annotated locations for NP_976251.1

    Status: REVIEWED

    Source sequence(s)
    AC013476, AC016712
    Consensus CDS
    CCDS2455.1
    UniProtKB/Swiss-Prot
    O95573
    UniProtKB/TrEMBL
    A0A024R497
    Related
    ENSP00000375918.3, ENST00000392066.7
    Conserved Domains (1) summary
    cl17068
    Location:30717
    AFD_class_I; Adenylate forming domain, Class I superfamily

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    222861036..222944639
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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