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Rapgef5 Rap guanine nucleotide exchange factor (GEF) 5 [ Mus musculus (house mouse) ]

Gene ID: 217944, updated on 5-Jan-2022

Summary

Official Symbol
Rapgef5provided by MGI
Official Full Name
Rap guanine nucleotide exchange factor (GEF) 5provided by MGI
Primary source
MGI:MGI:2444365
See related
Ensembl:ENSMUSG00000041992
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
GFR; Mrgef; C86120; mmr-gef; mKIAA0277; 4932413M22; D030051B22Rik
Summary
Predicted to enable GTP-dependent protein binding activity and guanyl-nucleotide exchange factor activity. Predicted to be involved in small GTPase mediated signal transduction. Predicted to be located in nuclear body. Is expressed in several structures, including alimentary system; branchial arch; central nervous system; heart and pericardium; and sensory organ. Orthologous to human RAPGEF5 (Rap guanine nucleotide exchange factor 5). [provided by Alliance of Genome Resources, Nov 2021]
Expression
Broad expression in lung adult (RPKM 12.6), cortex adult (RPKM 11.5) and 23 other tissues See more
Orthologs
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Genomic context

See Rapgef5 in Genome Data Viewer
Location:
12; 12 F2
Exon count:
31
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (117480146..117723472)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (117516526..117759737)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 12 NC_000078.5 (118754952..118995451)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 39559 Neighboring gene predicted gene, 31482 Neighboring gene predicted gene, 53774 Neighboring gene heterogeneous nuclear ribonucleoprotein A2/B1 pseudogene Neighboring gene 60S acidic ribosomal protein P2 pseudogene Neighboring gene cell division cycle associated 7 like Neighboring gene dynein, axonemal, heavy chain 11

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GTP-dependent protein binding ISO
Inferred from Sequence Orthology
more info
 
enables guanyl-nucleotide exchange factor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables guanyl-nucleotide exchange factor activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in Ras protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in small GTPase mediated signal transduction IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in nuclear body ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
rap guanine nucleotide exchange factor 5
Names
M-Ras-regulated Rap GEF
MR-GEF
Mras regulated guanine nucleotide exchange factor
guanine nucleotide exchange factor for Rap1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001373989.1NP_001360918.1  rap guanine nucleotide exchange factor 5 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC139993, AC163283, AC163286
    Conserved Domains (3) summary
    smart00147
    Location:639878
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    smart00229
    Location:367498
    RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
    cd04437
    Location:98221
    DEP_Epac; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in Epac-like proteins. Epac (exchange proteins directly activated by cAMP) proteins are GEFs (guanine-nucleotide-exchange factors) for the small GTPases, Rap1 and Rap2. They are directly regulated by ...
  2. NM_175930.6NP_787126.3  rap guanine nucleotide exchange factor 5 isoform 2

    See identical proteins and their annotated locations for NP_787126.3

    Status: VALIDATED

    Source sequence(s)
    AC139993, AC163283, AC163286
    Consensus CDS
    CCDS36577.1
    UniProtKB/Swiss-Prot
    Q8C0Q9
    Related
    ENSMUSP00000105313.3, ENSMUST00000109691.4
    Conserved Domains (3) summary
    smart00147
    Location:574813
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    smart00229
    Location:302433
    RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
    cd04437
    Location:33156
    DEP_Epac; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in Epac-like proteins. Epac (exchange proteins directly activated by cAMP) proteins are GEFs (guanine-nucleotide-exchange factors) for the small GTPases, Rap1 and Rap2. They are directly regulated by ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J

    Range
    117480146..117723472
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036157373.1XP_036013266.1  rap guanine nucleotide exchange factor 5 isoform X2

    Conserved Domains (2) summary
    smart00229
    Location:410514
    RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
    cd04437
    Location:141264
    DEP_Epac; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in Epac-like proteins. Epac (exchange proteins directly activated by cAMP) proteins are GEFs (guanine-nucleotide-exchange factors) for the small GTPases, Rap1 and Rap2. They are directly regulated by ...
  2. XM_030246682.2XP_030102542.1  rap guanine nucleotide exchange factor 5 isoform X1

    Conserved Domains (3) summary
    smart00147
    Location:598837
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    smart00229
    Location:326457
    RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
    cd04437
    Location:57180
    DEP_Epac; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in Epac-like proteins. Epac (exchange proteins directly activated by cAMP) proteins are GEFs (guanine-nucleotide-exchange factors) for the small GTPases, Rap1 and Rap2. They are directly regulated by ...
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