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Rapgef5 Rap guanine nucleotide exchange factor (GEF) 5 [ Mus musculus (house mouse) ]

Gene ID: 217944, updated on 1-Jan-2019

Summary

Official Symbol
Rapgef5provided by MGI
Official Full Name
Rap guanine nucleotide exchange factor (GEF) 5provided by MGI
Primary source
MGI:MGI:2444365
See related
Ensembl:ENSMUSG00000041992
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
GFR; Mrgef; C86120; mmr-gef; mKIAA0277; 4932413M22; D030051B22Rik
Expression
Broad expression in lung adult (RPKM 12.6), cortex adult (RPKM 11.5) and 23 other tissues See more
Orthologs

Genomic context

See Rapgef5 in Genome Data Viewer
Location:
12; 12 F2
Exon count:
29
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 12 NC_000078.6 (117516479..117759737)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 12 NC_000078.5 (118754952..118995451)

Chromosome 12 - NC_000078.6Genomic Context describing neighboring genes Neighboring gene protein tyrosine phosphatase, receptor type, N polypeptide 2 Neighboring gene predicted gene 5441 Neighboring gene microRNA 153 Neighboring gene predicted gene, 31482 Neighboring gene heterogeneous nuclear ribonucleoprotein A2/B1 pseudogene Neighboring gene cell division cycle associated 7 like Neighboring gene dynein, axonemal, heavy chain 11 Neighboring gene trans-acting transcription factor 4

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Pathways from BioSystems

  • Rap1 signaling pathway, organism-specific biosystem (from KEGG)
    Rap1 signaling pathway, organism-specific biosystemRap1 is a small GTPase that controls diverse processes, such as cell adhesion, cell-cell junction formation and cell polarity. Like all G proteins, Rap1 cycles between an inactive GDP-bound and an ac...
  • Rap1 signaling pathway, conserved biosystem (from KEGG)
    Rap1 signaling pathway, conserved biosystemRap1 is a small GTPase that controls diverse processes, such as cell adhesion, cell-cell junction formation and cell polarity. Like all G proteins, Rap1 cycles between an inactive GDP-bound and an ac...
  • Ras signaling pathway, organism-specific biosystem (from KEGG)
    Ras signaling pathway, organism-specific biosystemThe Ras proteins are GTPases that function as molecular switches for signaling pathways regulating cell proliferation, survival, growth, migration, differentiation or cytoskeletal dynamism. Ras prote...

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
GTP-dependent protein binding ISO
Inferred from Sequence Orthology
more info
 
Rap guanyl-nucleotide exchange factor activity ISO
Inferred from Sequence Orthology
more info
 
guanyl-nucleotide exchange factor activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
 
small GTPase mediated signal transduction IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
nuclear body ISO
Inferred from Sequence Orthology
more info
 
nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
rap guanine nucleotide exchange factor 5
Names
M-Ras-regulated Rap GEF
MR-GEF
Mras regulated guanine nucleotide exchange factor
guanine nucleotide exchange factor for Rap1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_175930.5NP_787126.3  rap guanine nucleotide exchange factor 5

    See identical proteins and their annotated locations for NP_787126.3

    Status: VALIDATED

    Source sequence(s)
    AC139993, AC163286, AK029995
    Consensus CDS
    CCDS36577.1
    UniProtKB/Swiss-Prot
    Q8C0Q9
    Related
    ENSMUSP00000105313.2, ENSMUST00000109691.3
    Conserved Domains (3) summary
    smart00147
    Location:574813
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    smart00229
    Location:302433
    RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
    cd04437
    Location:33156
    DEP_Epac; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in Epac-like proteins. Epac (exchange proteins directly activated by cAMP) proteins are GEFs (guanine-nucleotide-exchange factors) for the small GTPases, Rap1 and Rap2. They are directly regulated by ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000078.6 Reference GRCm38.p4 C57BL/6J

    Range
    117516479..117759737
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006515781.3XP_006515844.1  rap guanine nucleotide exchange factor 5 isoform X1

    Conserved Domains (3) summary
    smart00147
    Location:682921
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    smart00229
    Location:410541
    RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
    cd04437
    Location:141264
    DEP_Epac; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in Epac-like proteins. Epac (exchange proteins directly activated by cAMP) proteins are GEFs (guanine-nucleotide-exchange factors) for the small GTPases, Rap1 and Rap2. They are directly regulated by ...
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