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Dync2i1 dynein 2 intermediate chain 1 [ Mus musculus (house mouse) ]

Gene ID: 217935, updated on 5-Jan-2023

Summary

Official Symbol
Dync2i1provided by MGI
Official Full Name
dynein 2 intermediate chain 1provided by MGI
Primary source
MGI:MGI:2445085
See related
Ensembl:ENSMUSG00000042050 AllianceGenome:MGI:2445085
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Wdr60; Dync2l1; D430033N04Rik
Summary
Predicted to enable dynein heavy chain binding activity and dynein light chain binding activity. Predicted to be involved in cilium assembly; embryonic skeletal system morphogenesis; and intraciliary retrograde transport. Predicted to act upstream of or within cell projection organization. Located in cilium. Is expressed in mandible; maxilla; olfactory epithelium; and orbito-sphenoid. Human ortholog(s) of this gene implicated in short-rib thoracic dysplasia 8 with or without polydactyly. Orthologous to human DYNC2I1 (dynein 2 intermediate chain 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in testis adult (RPKM 6.3), frontal lobe adult (RPKM 3.7) and 21 other tissues See more
Orthologs
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Genomic context

See Dync2i1 in Genome Data Viewer
Location:
12; 12 F2
Exon count:
24
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (116169881..116226665, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (116206261..116263046, complement)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 23732 Neighboring gene predicted gene, 46330 Neighboring gene extended synaptotagmin-like protein 2 Neighboring gene RIKEN cDNA D430020J02 gene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Clone Names

  • MGC29335

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables dynein heavy chain binding IEA
Inferred from Electronic Annotation
more info
 
enables dynein light chain binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within cell projection organization IEA
Inferred from Electronic Annotation
more info
 
involved_in cilium assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in embryonic skeletal system morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in intraciliary retrograde transport ISO
Inferred from Sequence Orthology
more info
 
involved_in intraciliary transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cell projection IEA
Inferred from Electronic Annotation
more info
 
colocalizes_with centrosome ISO
Inferred from Sequence Orthology
more info
 
located_in centrosome ISO
Inferred from Sequence Orthology
more info
 
colocalizes_with ciliary base ISO
Inferred from Sequence Orthology
more info
 
located_in ciliary base ISO
Inferred from Sequence Orthology
more info
 
located_in cilium IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
part_of cytoplasmic dynein complex ISO
Inferred from Sequence Orthology
more info
 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
colocalizes_with interphase microtubule organizing center ISO
Inferred from Sequence Orthology
more info
 
located_in pericentriolar material ISO
Inferred from Sequence Orthology
more info
 
colocalizes_with spindle pole ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
cytoplasmic dynein 2 intermediate chain 1; WD repeat-containing protein 60
Names
WD repeat domain 60

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_146039.3NP_666151.3  cytoplasmic dynein 2 intermediate chain 1

    See identical proteins and their annotated locations for NP_666151.3

    Status: VALIDATED

    Source sequence(s)
    AK052482, AK144444, CJ150229
    Consensus CDS
    CCDS36575.1
    UniProtKB/Swiss-Prot
    Q3UNM4, Q8C761
    UniProtKB/TrEMBL
    Q3UN53
    Related
    ENSMUSP00000047334.7, ENSMUST00000039349.8
    Conserved Domains (4) summary
    COG2319
    Location:570966
    WD40; WD40 repeat [General function prediction only]
    pfam12871
    Location:52133
    PRP38_assoc; Pre-mRNA-splicing factor 38-associated hydrophilic C-term
    sd00039
    Location:808844
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:639927
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J

    Range
    116169881..116226665 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006515780.5XP_006515843.1  WD repeat-containing protein 60 isoform X1

    Conserved Domains (3) summary
    PTZ00121
    Location:48396
    PTZ00121; MAEBL; Provisional
    COG2319
    Location:6041000
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:842878
    7WD40; WD40 repeat [structural motif]
  2. XM_036157371.1XP_036013264.1  WD repeat-containing protein 60 isoform X2

    Conserved Domains (3) summary
    COG2319
    Location:430826
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:668704
    7WD40; WD40 repeat [structural motif]
    cl27104
    Location:69233
    Mak16; Mak16 protein C-terminal region
  3. XM_011244097.4XP_011242399.1  WD repeat-containing protein 60 isoform X3

    Conserved Domains (2) summary
    COG2319
    Location:145541
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:383419
    7WD40; WD40 repeat [structural motif]

RNA

  1. XR_381520.5 RNA Sequence

  2. XR_004937492.1 RNA Sequence