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Kcnk13 potassium channel, subfamily K, member 13 [ Mus musculus (house mouse) ]

Gene ID: 217826, updated on 24-Sep-2025
Official Symbol
Kcnk13provided by MGI
Official Full Name
potassium channel, subfamily K, member 13provided by MGI
Primary source
MGI:MGI:2384976
See related
Ensembl:ENSMUSG00000045404 AllianceGenome:MGI:2384976
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gm1570; Gm1685; F730021E22Rik
Summary
Predicted to enable identical protein binding activity; potassium channel activity; and protein heterodimerization activity. Involved in regulation of NLRP3 inflammasome complex assembly; regulation of excitatory synapse pruning; and regulation of resting membrane potential. Predicted to be part of monoatomic ion channel complex. Predicted to be active in plasma membrane. Is expressed in dentate gyrus subgranular zone and heart. Orthologous to human KCNK13 (potassium two pore domain channel subfamily K member 13). [provided by Alliance of Genome Resources, Apr 2025]
Expression
Broad expression in cerebellum adult (RPKM 2.1), frontal lobe adult (RPKM 1.7) and 24 other tissues See more
Orthologs
human all
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See Kcnk13 in Genome Data Viewer
Location:
12 E; 12 50.43 cM
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (99928132..100028941)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (99963149..100062682)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene EF-hand calcium binding domain 11 Neighboring gene STARR-seq mESC enhancer starr_33028 Neighboring gene phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoribosylaminoimidazole, succinocarboxamide synthetase pseudogene Neighboring gene STARR-positive B cell enhancer mm9_chr12:101121576-101121877 Neighboring gene STARR-seq mESC enhancer starr_33029 Neighboring gene STARR-positive B cell enhancer mm9_chr12:101140770-101141071 Neighboring gene predicted gene, 57807 Neighboring gene tyrosyl-DNA phosphodiesterase 1 Neighboring gene STARR-seq mESC enhancer starr_33030 Neighboring gene predicted gene, 51957 Neighboring gene malate dehydrogenase 1, NAD (soluble) pseudogene Neighboring gene STARR-positive B cell enhancer mm9_chr12:101348195-101348496 Neighboring gene protease (prosome, macropain) 26S subunit, ATPase 1

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Related articles in PubMed

  1. The two pore potassium channel THIK-1 regulates NLRP3 inflammasome activation. Drinkall S, et al. Glia, 2022 Jul. PMID 35353387, Free PMC Article
  2. Differential contribution of THIK-1 K(+) channels and P2X7 receptors to ATP-mediated neuroinflammation by human microglia. Rifat A, et al. J Neuroinflammation, 2024 Feb 26. PMID 38409076, Free PMC Article
  3. Characterisation of C101248: A novel selective THIK-1 channel inhibitor for the modulation of microglial NLRP3-inflammasome. Ossola B, et al. Neuropharmacology, 2023 Feb 15. PMID 36375694, Free PMC Article
  4. KCNK13 potassium channels in the ventral tegmental area of rats are important for excitation of ventral tegmental area neurons by ethanol. You C, et al. Alcohol Clin Exp Res, 2021 Jul. PMID 33960499, Free PMC Article
  5. Synapse development is regulated by microglial THIK-1 K(+) channels. Izquierdo P, et al. Proc Natl Acad Sci U S A, 2021 Oct 19. PMID 34642249, Free PMC Article

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The two pore potassium channel THIK-1 regulates NLRP3 inflammasome activation.
    Title: The two pore potassium channel THIK-1 regulates NLRP3 inflammasome activation.
  2. KCNK13 potassium channels in the ventral tegmental area of rats are important for excitation of ventral tegmental area neurons by ethanol.
    Title: KCNK13 potassium channels in the ventral tegmental area of rats are important for excitation of ventral tegmental area neurons by ethanol.
  3. THIK-1 is the main K(+) channel expressed in microglia in situ. THIK-1 is tonically active, and its activity is potentiated by P2Y12 receptors. Microglial immune surveillance and cytokine release require THIK-1 channel activity.
    Title: Microglial Ramification, Surveillance, and Interleukin-1β Release Are Regulated by the Two-Pore Domain K(+) Channel THIK-1.
  4. Dysregulation of a potassium channel, THIK-1, targeted by caspase-8, accelerates cell shrinkage.
    Title: Dysregulation of a potassium channel, THIK-1, targeted by caspase-8 accelerates cell shrinkage.
  5. THIK-1 and THIK-2 are abundantly expressed in the proximal and distal nephron of the mammalian kidney.
    Title: Cellular localization of THIK-1 (K(2P)13.1) and THIK-2 (K(2P)12.1) K channels in the mammalian kidney.
Submit: New GeneRIF Correction

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (6) 

Markers

Homology

Clone Names

  • MGC31053

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables identical protein binding IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables identical protein binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables outward rectifier potassium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables potassium channel activity IEA
Inferred from Electronic Annotation
more info
  
enables potassium channel activity ISO
Inferred from Sequence Orthology
more info
  
enables potassium ion leak channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein heterodimerization activity IEA
Inferred from Electronic Annotation
more info
  
enables protein heterodimerization activity ISO
Inferred from Sequence Orthology
more info
  
enables protein heterodimerization activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in monoatomic ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in potassium ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in potassium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in potassium ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of NLRP3 inflammasome complex assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of excitatory synapse pruning IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of resting membrane potential IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
part_of monoatomic ion channel complex IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
Preferred Names
potassium channel subfamily K member 13
Names
THIK-1
tandem pore domain halothane-inhibited potassium channel 1

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001164426.1 → NP_001157898.1  potassium channel subfamily K member 13

    See identical proteins and their annotated locations for NP_001157898.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AC159243
    Consensus CDS
    CCDS26106.1
    UniProtKB/Swiss-Prot
    Q8R1P5
    UniProtKB/TrEMBL
    Q3TYG8
    Related
    ENSMUSP00000136882.2, ENSMUST00000177549.8
    Conserved Domains (1) summary
    pfam07885
    Location:88 → 150
    Ion_trans_2; Ion channel

  2. NM_001164427.1 → NP_001157899.1  potassium channel subfamily K member 13

    See identical proteins and their annotated locations for NP_001157899.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AC159243
    Consensus CDS
    CCDS26106.1
    UniProtKB/Swiss-Prot
    Q8R1P5
    UniProtKB/TrEMBL
    Q3TYG8
    Related
    ENSMUSP00000051846.9, ENSMUST00000049788.9
    Conserved Domains (1) summary
    pfam07885
    Location:88 → 150
    Ion_trans_2; Ion channel

  3. NM_146037.2 → NP_666149.1  potassium channel subfamily K member 13

    See identical proteins and their annotated locations for NP_666149.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AC159243
    Consensus CDS
    CCDS26106.1
    UniProtKB/Swiss-Prot
    Q8R1P5
    UniProtKB/TrEMBL
    Q3TYG8
    Related
    ENSMUSP00000123916.2, ENSMUST00000160413.8
    Conserved Domains (1) summary
    pfam07885
    Location:88 → 150
    Ion_trans_2; Ion channel

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J

    Range
    99928132..100028941
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030246665.2 → XP_030102525.1  potassium channel subfamily K member 13 isoform X1

    UniProtKB/Swiss-Prot
    Q8R1P5
    UniProtKB/TrEMBL
    Q3TYG8
    Conserved Domains (1) summary
    pfam07885
    Location:88 → 150
    Ion_trans_2; Ion channel

  2. XM_036157341.1 → XP_036013234.1  potassium channel subfamily K member 13 isoform X1

    UniProtKB/Swiss-Prot
    Q8R1P5
    UniProtKB/TrEMBL
    Q3TYG8
    Conserved Domains (1) summary
    pfam07885
    Location:88 → 150
    Ion_trans_2; Ion channel
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8R1P5.1 GenPept UniProtKB/Swiss-Prot:Q8R1P5

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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