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Tfdp1 transcription factor Dp 1 [ Mus musculus (house mouse) ]

Gene ID: 21781, updated on 30-Aug-2022

Summary

Official Symbol
Tfdp1provided by MGI
Official Full Name
transcription factor Dp 1provided by MGI
Primary source
MGI:MGI:101934
See related
Ensembl:ENSMUSG00000038482 AllianceGenome:MGI:101934
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Dp1; Drtf1
Summary
Enables DNA-binding transcription factor activity and cis-regulatory region sequence-specific DNA binding activity. Involved in negative regulation of fat cell proliferation. Acts upstream of or within anoikis; epidermis development; and regulation of cellular macromolecule biosynthetic process. Located in cytoplasm and nucleus. Part of transcription regulator complex. Is expressed in several structures, including alimentary system; central nervous system; early conceptus; genitourinary system; and retina. Orthologous to several human genes including TFDP1 (transcription factor Dp-1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 53.8), liver E14 (RPKM 51.3) and 28 other tissues See more
Orthologs
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Genomic context

See Tfdp1 in Genome Data Viewer
Location:
8; 8 A1.1
Exon count:
15
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (13388273..13428448)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (13338725..13378448)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 8 NC_000074.5 (13339674..13377702)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene DCN1, defective in cullin neddylation 1, domain containing 2 (S. cerevisiae) Neighboring gene predicted gene, 25014 Neighboring gene transmembrane and coiled-coil domains 3 Neighboring gene ATPase, H+/K+ exchanging, beta polypeptide Neighboring gene G protein-coupled receptor kinase 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Component Evidence Code Pubs
part_of RNA polymerase II transcription regulator complex ISO
Inferred from Sequence Orthology
more info
 
part_of Rb-E2F complex ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
part_of transcription regulator complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
transcription factor Dp-1
Names
DRTF1-polypeptide 1
E2F dimerization partner 1
cell cycle regulatory transcription factor DP1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001291765.1NP_001278694.1  transcription factor Dp-1 isoform a

    See identical proteins and their annotated locations for NP_001278694.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same isoform (a).
    Source sequence(s)
    AC130818, AK019997, AK030820, CO041118
    Consensus CDS
    CCDS22110.1
    UniProtKB/Swiss-Prot
    Q08639
    UniProtKB/TrEMBL
    Q3V3X3, Q9D297
    Related
    ENSMUSP00000147881.2, ENSMUST00000209885.2
    Conserved Domains (3) summary
    cd14458
    Location:198244
    DP_DD; coiled coil [structural motif]
    pfam02319
    Location:112193
    E2F_TDP; E2F/DP family winged-helix DNA-binding domain
    pfam08781
    Location:200338
    DP; Transcription factor DP
  2. NM_001291766.1NP_001278695.1  transcription factor Dp-1 isoform b

    See identical proteins and their annotated locations for NP_001278695.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame exon in the 5' coding region and uses a downstream start codon compared to variant 1. It encodes isoform b, which has a shorter N-terminus compared to isoform a. Variants 3, 4 and 5 encode the same isoform (b).
    Source sequence(s)
    AC130818, AK013180, AK019997, AK030820, CO041118
    Consensus CDS
    CCDS85506.1
    UniProtKB/TrEMBL
    Q3V3X3, Q9CYZ7, Q9D297
    Conserved Domains (3) summary
    cd14458
    Location:78124
    DP_DD; coiled coil [structural motif]
    pfam02319
    Location:173
    E2F_TDP; E2F/DP family winged-helix DNA-binding domain
    pfam08781
    Location:80218
    DP; Transcription factor DP
  3. NM_001291768.1NP_001278697.1  transcription factor Dp-1 isoform b

    See identical proteins and their annotated locations for NP_001278697.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and lacks an alternate in-frame exon in the 5' coding region, resulting in the use of a downstream start codon compared to variant 1. It encodes isoform b, which has a shorter N-terminus compared to isoform a. Variants 3, 4 and 5 encode the same isoform (b).
    Source sequence(s)
    AK019997, AK030820, BY089512, CO041118
    Consensus CDS
    CCDS85506.1
    UniProtKB/TrEMBL
    Q3V3X3, Q9CYZ7, Q9D297
    Related
    ENSMUSP00000147662.2, ENSMUST00000209396.2
    Conserved Domains (3) summary
    cd14458
    Location:78124
    DP_DD; coiled coil [structural motif]
    pfam02319
    Location:173
    E2F_TDP; E2F/DP family winged-helix DNA-binding domain
    pfam08781
    Location:80218
    DP; Transcription factor DP
  4. NM_001358991.1NP_001345920.1  transcription factor Dp-1 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) has an alternate exon in the 5' region and uses a downstream start codon compared to variant 1. It encodes isoform b, which has a shorter N-terminus compared to isoform a. Variants 3, 4 and 5 encode the same isoform (b).
    Source sequence(s)
    AC130818, CO041118
    Consensus CDS
    CCDS85506.1
    UniProtKB/TrEMBL
    Q9CYZ7
    Conserved Domains (3) summary
    cd14458
    Location:78124
    DP_DD; coiled coil [structural motif]
    pfam02319
    Location:173
    E2F_TDP; E2F/DP family winged-helix DNA-binding domain
    pfam08781
    Location:80218
    DP; Transcription factor DP
  5. NM_009361.3NP_033387.1  transcription factor Dp-1 isoform a

    See identical proteins and their annotated locations for NP_033387.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (a). Variants 1 and 2 both encode the same isoform (a).
    Source sequence(s)
    AC130818, AK019997, AK030820, CO041118
    Consensus CDS
    CCDS22110.1
    UniProtKB/Swiss-Prot
    Q08639
    UniProtKB/TrEMBL
    Q3V3X3, Q9D297
    Related
    ENSMUST00000211606.2
    Conserved Domains (3) summary
    cd14458
    Location:198244
    DP_DD; coiled coil [structural motif]
    pfam02319
    Location:112193
    E2F_TDP; E2F/DP family winged-helix DNA-binding domain
    pfam08781
    Location:200338
    DP; Transcription factor DP

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    13388273..13428448
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017312657.3XP_017168146.1  transcription factor Dp-1 isoform X1

    Conserved Domains (3) summary
    cd14458
    Location:200246
    DP_DD; coiled coil [structural motif]
    pfam02319
    Location:115195
    E2F_TDP; E2F/DP family winged-helix DNA-binding domain
    pfam08781
    Location:202340
    DP; Transcription factor DP
  2. XM_036153875.1XP_036009768.1  transcription factor Dp-1 isoform X3

    UniProtKB/TrEMBL
    Q9CYZ7
    Conserved Domains (3) summary
    cd14458
    Location:78124
    DP_DD; coiled coil [structural motif]
    pfam02319
    Location:173
    E2F_TDP; E2F/DP family winged-helix DNA-binding domain
    pfam08781
    Location:80218
    DP; Transcription factor DP
  3. XM_030243408.2XP_030099268.1  transcription factor Dp-1 isoform X3

    UniProtKB/TrEMBL
    Q9CYZ7
    Conserved Domains (3) summary
    cd14458
    Location:78124
    DP_DD; coiled coil [structural motif]
    pfam02319
    Location:173
    E2F_TDP; E2F/DP family winged-helix DNA-binding domain
    pfam08781
    Location:80218
    DP; Transcription factor DP
  4. XM_036153872.1XP_036009765.1  transcription factor Dp-1 isoform X1

    Conserved Domains (3) summary
    cd14458
    Location:200246
    DP_DD; coiled coil [structural motif]
    pfam02319
    Location:115195
    E2F_TDP; E2F/DP family winged-helix DNA-binding domain
    pfam08781
    Location:202340
    DP; Transcription factor DP
  5. XM_006508751.5XP_006508814.1  transcription factor Dp-1 isoform X2

    See identical proteins and their annotated locations for XP_006508814.1

    UniProtKB/Swiss-Prot
    Q08639
    UniProtKB/TrEMBL
    Q3V3X3
    Conserved Domains (3) summary
    cd14458
    Location:198244
    DP_DD; coiled coil [structural motif]
    pfam02319
    Location:112193
    E2F_TDP; E2F/DP family winged-helix DNA-binding domain
    pfam08781
    Location:200338
    DP; Transcription factor DP
  6. XM_036153873.1XP_036009766.1  transcription factor Dp-1 isoform X3

    UniProtKB/TrEMBL
    Q9CYZ7
    Conserved Domains (3) summary
    cd14458
    Location:78124
    DP_DD; coiled coil [structural motif]
    pfam02319
    Location:173
    E2F_TDP; E2F/DP family winged-helix DNA-binding domain
    pfam08781
    Location:80218
    DP; Transcription factor DP
  7. XM_017312659.3XP_017168148.1  transcription factor Dp-1 isoform X1

    Conserved Domains (3) summary
    cd14458
    Location:200246
    DP_DD; coiled coil [structural motif]
    pfam02319
    Location:115195
    E2F_TDP; E2F/DP family winged-helix DNA-binding domain
    pfam08781
    Location:202340
    DP; Transcription factor DP
  8. XM_030243403.2XP_030099263.1  transcription factor Dp-1 isoform X2

    UniProtKB/Swiss-Prot
    Q08639
    UniProtKB/TrEMBL
    Q3V3X3
    Conserved Domains (3) summary
    cd14458
    Location:198244
    DP_DD; coiled coil [structural motif]
    pfam02319
    Location:112193
    E2F_TDP; E2F/DP family winged-helix DNA-binding domain
    pfam08781
    Location:200338
    DP; Transcription factor DP
  9. XM_030243407.2XP_030099267.1  transcription factor Dp-1 isoform X3

    UniProtKB/TrEMBL
    Q9CYZ7
    Conserved Domains (3) summary
    cd14458
    Location:78124
    DP_DD; coiled coil [structural motif]
    pfam02319
    Location:173
    E2F_TDP; E2F/DP family winged-helix DNA-binding domain
    pfam08781
    Location:80218
    DP; Transcription factor DP
  10. XM_036153874.1XP_036009767.1  transcription factor Dp-1 isoform X3

    UniProtKB/TrEMBL
    Q9CYZ7
    Conserved Domains (3) summary
    cd14458
    Location:78124
    DP_DD; coiled coil [structural motif]
    pfam02319
    Location:173
    E2F_TDP; E2F/DP family winged-helix DNA-binding domain
    pfam08781
    Location:80218
    DP; Transcription factor DP
  11. XM_030243404.2XP_030099264.1  transcription factor Dp-1 isoform X3

    UniProtKB/TrEMBL
    Q9CYZ7
    Conserved Domains (3) summary
    cd14458
    Location:78124
    DP_DD; coiled coil [structural motif]
    pfam02319
    Location:173
    E2F_TDP; E2F/DP family winged-helix DNA-binding domain
    pfam08781
    Location:80218
    DP; Transcription factor DP
  12. XM_030243405.2XP_030099265.1  transcription factor Dp-1 isoform X3

    UniProtKB/TrEMBL
    Q9CYZ7
    Conserved Domains (3) summary
    cd14458
    Location:78124
    DP_DD; coiled coil [structural motif]
    pfam02319
    Location:173
    E2F_TDP; E2F/DP family winged-helix DNA-binding domain
    pfam08781
    Location:80218
    DP; Transcription factor DP
  13. XM_017312658.3XP_017168147.1  transcription factor Dp-1 isoform X1

    Conserved Domains (3) summary
    cd14458
    Location:200246
    DP_DD; coiled coil [structural motif]
    pfam02319
    Location:115195
    E2F_TDP; E2F/DP family winged-helix DNA-binding domain
    pfam08781
    Location:202340
    DP; Transcription factor DP
  14. XM_030243410.2XP_030099270.1  transcription factor Dp-1 isoform X3

    UniProtKB/TrEMBL
    Q9CYZ7
    Conserved Domains (3) summary
    cd14458
    Location:78124
    DP_DD; coiled coil [structural motif]
    pfam02319
    Location:173
    E2F_TDP; E2F/DP family winged-helix DNA-binding domain
    pfam08781
    Location:80218
    DP; Transcription factor DP
  15. XM_030243409.2XP_030099269.1  transcription factor Dp-1 isoform X3

    UniProtKB/TrEMBL
    Q9CYZ7
    Conserved Domains (3) summary
    cd14458
    Location:78124
    DP_DD; coiled coil [structural motif]
    pfam02319
    Location:173
    E2F_TDP; E2F/DP family winged-helix DNA-binding domain
    pfam08781
    Location:80218
    DP; Transcription factor DP
  16. XM_006508755.3XP_006508818.1  transcription factor Dp-1 isoform X3

    See identical proteins and their annotated locations for XP_006508818.1

    UniProtKB/TrEMBL
    Q9CYZ7
    Conserved Domains (3) summary
    cd14458
    Location:78124
    DP_DD; coiled coil [structural motif]
    pfam02319
    Location:173
    E2F_TDP; E2F/DP family winged-helix DNA-binding domain
    pfam08781
    Location:80218
    DP; Transcription factor DP
  17. XM_011242048.2XP_011240350.1  transcription factor Dp-1 isoform X3

    See identical proteins and their annotated locations for XP_011240350.1

    UniProtKB/TrEMBL
    Q9CYZ7
    Conserved Domains (3) summary
    cd14458
    Location:78124
    DP_DD; coiled coil [structural motif]
    pfam02319
    Location:173
    E2F_TDP; E2F/DP family winged-helix DNA-binding domain
    pfam08781
    Location:80218
    DP; Transcription factor DP
  18. XM_030243406.2XP_030099266.1  transcription factor Dp-1 isoform X3

    UniProtKB/TrEMBL
    Q9CYZ7
    Conserved Domains (3) summary
    cd14458
    Location:78124
    DP_DD; coiled coil [structural motif]
    pfam02319
    Location:173
    E2F_TDP; E2F/DP family winged-helix DNA-binding domain
    pfam08781
    Location:80218
    DP; Transcription factor DP