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Ism2 isthmin 2 [ Mus musculus (house mouse) ]

Gene ID: 217738, updated on 17-Aug-2024

Summary

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Official Symbol
Ism2provided by MGI
Official Full Name
isthmin 2provided by MGI
Primary source
MGI:MGI:2685110
See related
Ensembl:ENSMUSG00000050671 AllianceGenome:MGI:2685110
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gm264; Thsd3
Summary
Is expressed in embryo. Orthologous to human ISM2 (isthmin 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in genital fat pad adult (RPKM 2.0), subcutaneous fat pad adult (RPKM 1.1) and 14 other tissues See more
Orthologs
human all
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Genomic context

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Location:
12 D2; 12 41.49 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (87325412..87346624, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (87278638..87299850, complement)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene VPS33B interacting protein, apical-basolateral polarity regulator, spe-39 homolog Neighboring gene AHA1, activator of heat shock protein ATPase 1 Neighboring gene predicted gene, 53736 Neighboring gene STARR-seq mESC enhancer starr_32874 Neighboring gene predicted gene, 51956 Neighboring gene STARR-seq mESC enhancer starr_32879 Neighboring gene serine palmitoyltransferase, long chain base subunit 2 Neighboring gene CapStarr-seq enhancer MGSCv37_chr12:88729340-88729523 Neighboring gene predicted gene, 33444 Neighboring gene STARR-seq mESC enhancer starr_32884 Neighboring gene 60S ribosomal protein L21-like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. O-fucosylation of thrombospondin type 1 repeats restricts epithelial to mesenchymal transition (EMT) and maintains epiblast pluripotency during mouse gastrulation. Du J, et al. Dev Biol, 2010 Oct 1. PMID 20637190, Free PMC Article
  2. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Gene trapped (1) 
  • Targeted (2) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  

General protein information

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Preferred Names
isthmin-2
Names
isthmin 2 homolog
thrombospondin, type I, domain containing 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001290302.1 → NP_001277231.1  isthmin-2 precursor

    Status: VALIDATED

    Source sequence(s)
    AC151967, BQ032954, BU054611, CT030249
    Consensus CDS
    CCDS70410.1
    UniProtKB/TrEMBL
    D3Z6A3, F6YQQ5
    Related
    ENSMUSP00000117108.2, ENSMUST00000125733.8
    Conserved Domains (2) summary
    smart00209
    Location:252 → 292
    TSP1; Thrombospondin type 1 repeats
    cl02758
    Location:321 → 481
    AMOP; AMOP domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J

    Range
    87325412..87346624 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036157339.1 → XP_036013232.1  isthmin-2 isoform X1

    Conserved Domains (2) summary
    smart00209
    Location:113 → 153
    TSP1; Thrombospondin type 1 repeats
    cl02758
    Location:182 → 342
    AMOP; AMOP domain

RNA

  1. XR_003950040.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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