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Ppp2r5d protein phosphatase 2, regulatory subunit B', delta [ Mus musculus (house mouse) ]

Gene ID: 21770, updated on 27-Nov-2024

Summary

Official Symbol
Ppp2r5dprovided by MGI
Official Full Name
protein phosphatase 2, regulatory subunit B', deltaprovided by MGI
Primary source
MGI:MGI:2388481
See related
Ensembl:ENSMUSG00000059409 AllianceGenome:MGI:2388481
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Tex271; B'delta; TEG-271
Summary
Enables protein phosphatase activator activity. Predicted to be involved in negative regulation of peptidyl-threonine phosphorylation and protein dephosphorylation. Predicted to act upstream of or within several processes, including positive regulation of neurotrophin TRK receptor signaling pathway; positive regulation of transcription by RNA polymerase II; and regulation of protein autophosphorylation. Predicted to be part of protein phosphatase type 2A complex. Predicted to be active in cytosol and nucleus. Is expressed in several structures, including brain; gonad; hemolymphoid system gland; liver; and lung. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder 35. Orthologous to human PPP2R5D (protein phosphatase 2 regulatory subunit B'delta). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in large intestine adult (RPKM 36.1), CNS E11.5 (RPKM 34.1) and 28 other tissues See more
Orthologs
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Genomic context

See Ppp2r5d in Genome Data Viewer
Location:
17 22.9 cM; 17 C
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (46993917..47015952, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (46682991..46705026, complement)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_42676 Neighboring gene ribosomal RNA processing 36 Neighboring gene kelch domain containing 3 Neighboring gene STARR-positive B cell enhancer mm9_chr17:46817738-46818039 Neighboring gene male enhanced antigen 1 Neighboring gene STARR-positive B cell enhancer ABC_E7538 Neighboring gene peroxisomal biogenesis factor 6 Neighboring gene glycine N-methyltransferase

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Gene trapped (1) 
  • Targeted (1)  1 citation

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables phosphoprotein phosphatase activity ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein phosphatase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein phosphatase activator activity IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of protein phosphatase type 2A complex IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform
Names
testis expressed gene 271

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001357684.1NP_001344613.1  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform isoform 2

    Status: VALIDATED

    Source sequence(s)
    BE948258, CT030702
    Consensus CDS
    CCDS89107.1
    UniProtKB/TrEMBL
    Q7TNL5, Q99PC9
    Related
    ENSMUSP00000156500.2, ENSMUST00000233988.2
    Conserved Domains (2) summary
    pfam01603
    Location:101506
    B56; Protein phosphatase 2A regulatory B subunit (B56 family)
    cl27532
    Location:49115
    B56; Protein phosphatase 2A regulatory B subunit (B56 family)
  2. NM_009358.3NP_033384.2  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform isoform 1

    See identical proteins and their annotated locations for NP_033384.2

    Status: VALIDATED

    Source sequence(s)
    AK160587, CJ042073, CT030702
    Consensus CDS
    CCDS28836.1
    UniProtKB/TrEMBL
    Q91V89, Q99PC9
    Related
    ENSMUSP00000002839.9, ENSMUST00000002839.9
    Conserved Domains (2) summary
    pfam01603
    Location:100505
    B56; Protein phosphatase 2A regulatory B subunit (B56 family)
    cl27532
    Location:48114
    B56; Protein phosphatase 2A regulatory B subunit (B56 family)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    46993917..47015952 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)