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Acot5 acyl-CoA thioesterase 5 [ Mus musculus (house mouse) ]

Gene ID: 217698, updated on 12-May-2024

Summary

Official Symbol
Acot5provided by MGI
Official Full Name
acyl-CoA thioesterase 5provided by MGI
Primary source
MGI:MGI:2384969
See related
Ensembl:ENSMUSG00000042540 AllianceGenome:MGI:2384969
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
PTE-Ic
Summary
Enables acyl-CoA hydrolase activity. Involved in acyl-CoA metabolic process; monocarboxylic acid metabolic process; and saturated monocarboxylic acid metabolic process. Located in cytosol and peroxisome. Orthologous to human ACOT1 (acyl-CoA thioesterase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in ovary adult (RPKM 10.1), kidney adult (RPKM 7.8) and 26 other tissues See more
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Genomic context

See Acot5 in Genome Data Viewer
Location:
12 D1; 12 39.03 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (84115908..84122798)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (84069077..84076024)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 40474 Neighboring gene acyl-CoA thioesterase 4 Neighboring gene acyl-CoA thioesterase 3 Neighboring gene acyl-CoA thioesterase 5 pseudogene Neighboring gene STARR-seq mESC enhancer starr_32724 Neighboring gene acyl-CoA thioesterase 6

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables carboxylic ester hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables fatty acyl-CoA hydrolase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables fatty acyl-CoA hydrolase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables fatty acyl-CoA hydrolase activity ISO
Inferred from Sequence Orthology
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables thiolester hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in peroxisome IDA
Inferred from Direct Assay
more info
PubMed 
located_in peroxisome TAS
Traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
acyl-coenzyme A thioesterase 5
Names
peroxisomal acyl-CoA thioesterase Ic
peroxisomal acyl-coenzyme A thioester hydrolase Ic
NP_001334346.1
NP_663419.3
XP_006515756.4
XP_011242377.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001347417.1NP_001334346.1  acyl-coenzyme A thioesterase 5 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC125071
    Consensus CDS
    CCDS83986.1
    UniProtKB/TrEMBL
    Q91YQ6
    Related
    ENSMUSP00000072322.5, ENSMUST00000072505.5
  2. NM_145444.3NP_663419.3  acyl-coenzyme A thioesterase 5 isoform 1

    See identical proteins and their annotated locations for NP_663419.3

    Status: VALIDATED

    Source sequence(s)
    AC125071
    Consensus CDS
    CCDS26037.1
    UniProtKB/Swiss-Prot
    E9QKJ5, Q6Q2Z6
    Related
    ENSMUSP00000042019.5, ENSMUST00000046422.11
    Conserved Domains (3) summary
    pfam04775
    Location:16137
    Bile_Hydr_Trans; Acyl-CoA thioester hydrolase/BAAT N-terminal region
    pfam08840
    Location:204412
    BAAT_C; BAAT / Acyl-CoA thioester hydrolase C terminal
    cl21494
    Location:145259
    Abhydrolase; alpha/beta hydrolases

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J

    Range
    84115908..84122798
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006515693.5XP_006515756.4  acyl-coenzyme A thioesterase 5 isoform X1

    UniProtKB/Swiss-Prot
    E9QKJ5, Q6Q2Z6
    Conserved Domains (3) summary
    pfam04775
    Location:16137
    Bile_Hydr_Trans; Acyl-CoA thioester hydrolase/BAAT N-terminal region
    pfam08840
    Location:204412
    BAAT_C; BAAT / Acyl-CoA thioester hydrolase C terminal
    cl21494
    Location:145259
    Abhydrolase; alpha/beta hydrolases
  2. XM_011244075.4XP_011242377.1  acyl-coenzyme A thioesterase 5 isoform X2

    Conserved Domains (2) summary
    pfam04775
    Location:16137
    Bile_Hydr_Trans; Acyl-CoA thioester hydrolase/BAAT N-terminal region
    cl21494
    Location:204221
    Abhydrolase; alpha/beta hydrolases