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Mbip MAP3K12 binding inhibitory protein 1 [ Mus musculus (house mouse) ]

Gene ID: 217588, updated on 8-Dec-2022


Official Symbol
Mbipprovided by MGI
Official Full Name
MAP3K12 binding inhibitory protein 1provided by MGI
Primary source
See related
Ensembl:ENSMUSG00000021028 AllianceGenome:MGI:1918320
Gene type
protein coding
RefSeq status
Mus musculus
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Predicted to enable identical protein binding activity and protein kinase inhibitor activity. Predicted to be involved in histone H3 acetylation; positive regulation of JNK cascade; and positive regulation of gene expression. Located in nucleus. Part of ATAC complex. Is expressed in lung and telencephalon. Orthologous to human MBIP (MAP3K12 binding inhibitory protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Ubiquitous expression in CNS E14 (RPKM 9.9), CNS E11.5 (RPKM 9.1) and 26 other tissues See more
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Genomic context

See Mbip in Genome Data Viewer
12; 12 C1
Exon count:
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (56375091..56392681, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (56328306..56345933, complement)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 19990 Neighboring gene predicted gene, 46351 Neighboring gene predicted gene, 53723 Neighboring gene cytochrome c oxidase subunit 6C2 Neighboring gene predicted gene, 18027

Genomic regions, transcripts, and products


  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a



Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 


Products Interactant Other Gene Complex Source Pubs Description

General gene information



Clone Names

  • MGC7681

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
enables protein binding IPI
Inferred from Physical Interaction
more info
enables protein kinase inhibitor activity ISO
Inferred from Sequence Orthology
more info
Component Evidence Code Pubs
part_of ATAC complex IDA
Inferred from Direct Assay
more info
part_of ATAC complex ISO
Inferred from Sequence Orthology
more info
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
located_in cytosol ISO
Inferred from Sequence Orthology
more info
located_in mitotic spindle NAS
Non-traceable Author Statement
more info
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
located_in nucleus IDA
Inferred from Direct Assay
more info

General protein information

Preferred Names
MAP3K12-binding inhibitory protein 1
MAPK upstream kinase-binding inhibitory protein
MUK-binding inhibitory protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_145442.2NP_663417.1  MAP3K12-binding inhibitory protein 1

    See identical proteins and their annotated locations for NP_663417.1

    Status: VALIDATED

    Source sequence(s)
    AC154714, AK077125
    Consensus CDS
    Q3TBM3, Q99LQ1
    ENSMUSP00000021416.8, ENSMUST00000021416.9

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J


  1. NC_000078.7 Reference GRCm39 C57BL/6J

    56375091..56392681 complement
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030246648.2XP_030102508.1  MAP3K12-binding inhibitory protein 1 isoform X3

  2. XM_006515674.5XP_006515737.1  MAP3K12-binding inhibitory protein 1 isoform X2

  3. XM_006515673.5XP_006515736.1  MAP3K12-binding inhibitory protein 1 isoform X1

  4. XM_017315023.3XP_017170512.1  MAP3K12-binding inhibitory protein 1 isoform X5

  5. XM_017315021.3XP_017170510.1  MAP3K12-binding inhibitory protein 1 isoform X4


  1. XR_004937488.1 RNA Sequence

  2. XR_004937487.1 RNA Sequence