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Prss39 serine protease 39 [ Mus musculus (house mouse) ]

Gene ID: 21755, updated on 9-Dec-2024

Summary

Official Symbol
Prss39provided by MGI
Official Full Name
serine protease 39provided by MGI
Primary source
MGI:MGI:1270856
See related
Ensembl:ENSMUSG00000026125 AllianceGenome:MGI:1270856
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Tesp1
Summary
Predicted to enable serine-type endopeptidase activity. Predicted to be involved in proteolysis. Predicted to be located in acrosomal vesicle and extracellular region. Predicted to be active in extracellular space. [provided by Alliance of Genome Resources, Dec 2024]
Expression
Restricted expression toward testis adult (RPKM 299.9) See more
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Genomic context

See Prss39 in Genome Data Viewer
Location:
1 B; 1 13.29 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (34537493..34542143)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (34498412..34503062)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene protein tyrosine phosphatase, non-receptor type 18 Neighboring gene RIKEN cDNA 4930568A12 gene Neighboring gene predicted gene 28417 Neighboring gene predicted gene, 32566 Neighboring gene serine protease 40 Neighboring gene predicted gene 28419 Neighboring gene cryptic, EGF-CFC family member 1 Neighboring gene regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 1 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

General gene information

Markers

Clone Names

  • MGC144580, MGC144581

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables serine-type endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables serine-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in proteolysis IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in acrosomal vesicle IEA
Inferred from Electronic Annotation
more info
 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
inactive serine protease 39
Names
inactive testicular serine protease 1
protease, serine 39
testicular serine protease 1
NP_001347784.1
NP_033381.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001360855.1NP_001347784.1  inactive serine protease 39 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (2) is shorter at the N-terminus compared to isoform 1.
    Source sequence(s)
    AC106841
    Conserved Domains (1) summary
    cd00190
    Location:3173
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
  2. NM_009355.3NP_033381.1  inactive serine protease 39 isoform 1 precursor

    See identical proteins and their annotated locations for NP_033381.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AC106841, BC049616, BY716157
    Consensus CDS
    CCDS14868.1
    UniProtKB/Swiss-Prot
    O70169, Q80YD5
    Related
    ENSMUSP00000027299.4, ENSMUST00000027299.10
    Conserved Domains (2) summary
    smart00020
    Location:67307
    Tryp_SPc; Trypsin-like serine protease
    cd00190
    Location:68310
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    34537493..34542143
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)