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Trib2 tribbles pseudokinase 2 [ Mus musculus (house mouse) ]

Gene ID: 217410, updated on 5-Mar-2024

Summary

Official Symbol
Trib2provided by MGI
Official Full Name
tribbles pseudokinase 2provided by MGI
Primary source
MGI:MGI:2145021
See related
Ensembl:ENSMUSG00000020601 AllianceGenome:MGI:2145021
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
TRB2; TRB-2
Summary
Enables ubiquitin protein ligase binding activity and ubiquitin-protein transferase regulator activity. Involved in negative regulation of fat cell differentiation and positive regulation of proteasomal ubiquitin-dependent protein catabolic process. Predicted to be located in cytoplasm and cytoskeleton. Predicted to be active in nucleus. Is expressed in several structures, including alimentary system; cardiovascular system; central nervous system; genitourinary system; and integumental system. Orthologous to human TRIB2 (tribbles pseudokinase 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in ovary adult (RPKM 34.9), whole brain E14.5 (RPKM 27.6) and 17 other tissues See more
Orthologs
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Genomic context

See Trib2 in Genome Data Viewer
Location:
12 A1.1; 12 7.25 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (15841726..15866963, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (15791725..15816962, complement)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene predicted gene, 53738 Neighboring gene STARR-seq mESC enhancer starr_31625 Neighboring gene microRNA 6387 Neighboring gene predicted gene 5432 Neighboring gene predicted gene, 46335 Neighboring gene predicted gene, 53739 Neighboring gene predicted gene, 48584

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables RNA polymerase II-specific DNA-binding transcription factor binding IDA
Inferred from Direct Assay
more info
PubMed 
enables mitogen-activated protein kinase kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein kinase inhibitor activity IEA
Inferred from Electronic Annotation
more info
 
enables ubiquitin protein ligase binding IDA
Inferred from Direct Assay
more info
PubMed 
enables ubiquitin-protein transferase regulator activity IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001422844.1NP_001409773.1  tribbles homolog 2

    Status: VALIDATED

    Source sequence(s)
    AC159643
    UniProtKB/Swiss-Prot
    Q8K017, Q8K4K3, Q8R2V8
  2. NM_144551.6NP_653134.2  tribbles homolog 2

    See identical proteins and their annotated locations for NP_653134.2

    Status: VALIDATED

    Source sequence(s)
    AC159643
    Consensus CDS
    CCDS25821.1
    UniProtKB/Swiss-Prot
    Q8K017, Q8K4K3, Q8R2V8
    Related
    ENSMUSP00000020922.8, ENSMUST00000020922.8
    Conserved Domains (1) summary
    cd14022
    Location:67308
    PK_TRB2; Pseudokinase domain of Tribbles Homolog 2

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J

    Range
    15841726..15866963 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006515055.2XP_006515118.1  tribbles homolog 2 isoform X2

    Conserved Domains (1) summary
    cl21453
    Location:45273
    PKc_like; Protein Kinases, catalytic domain