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Uts2r urotensin 2 receptor [ Mus musculus (house mouse) ]

Gene ID: 217369, updated on 5-Jan-2023

Summary

Official Symbol
Uts2rprovided by MGI
Official Full Name
urotensin 2 receptorprovided by MGI
Primary source
MGI:MGI:2183450
See related
Ensembl:ENSMUSG00000039321 AllianceGenome:MGI:2183450
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
UTR; UTR2; Gpr14; UR-2-R
Summary
Predicted to enable urotensin II receptor activity. Predicted to be involved in several processes, including positive regulation of circadian sleep/wake cycle, REM sleep; positive regulation of circadian sleep/wake cycle, wakefulness; and regulation of blood pressure. Predicted to act upstream of or within signal transduction. Predicted to be located in early endosome; plasma membrane; and recycling endosome. Predicted to be integral component of plasma membrane. Orthologous to human UTS2R (urotensin 2 receptor). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

See Uts2r in Genome Data Viewer
Location:
11; 11 E2
Exon count:
1
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (121051097..121052799)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (121160271..121161973)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene testis expressed gene 19.2 Neighboring gene testis expressed gene 19.1 Neighboring gene bromodomain containing 4 pseudogene Neighboring gene 2-oxoglutarate and iron-dependent oxygenase domain containing 3 Neighboring gene hexosaminidase (glycosyl hydrolase family 20, catalytic domain) containing

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
 
enables urotensin II receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables urotensin II receptor activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in blood vessel diameter maintenance IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of blood pressure ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of glomerular filtration ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of renal sodium excretion ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of urine volume ISO
Inferred from Sequence Orthology
more info
 
involved_in neuropeptide signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of angiogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of blood pressure ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell growth ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of circadian sleep/wake cycle, REM sleep ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of circadian sleep/wake cycle, wakefulness ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cytosolic calcium ion concentration ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of fibroblast proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of vasoconstriction ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of blood pressure IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within signal transduction IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in early endosome ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in recycling endosome ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
urotensin-2 receptor
Names
G protein-coupled receptor 14
UR-II-R
urotensin II receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_145440.1NP_663415.1  urotensin-2 receptor

    See identical proteins and their annotated locations for NP_663415.1

    Status: PROVISIONAL

    Source sequence(s)
    AF441863
    Consensus CDS
    CCDS25769.1
    UniProtKB/Swiss-Prot
    Q8VIH9
    UniProtKB/TrEMBL
    A0A8C6GXZ6, Q05AD1
    Related
    ENSMUSP00000046920.2, ENSMUST00000039044.2
    Conserved Domains (1) summary
    pfam00001
    Location:72316
    7tm_1; 7 transmembrane receptor (rhodopsin family)

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    121051097..121052799
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)