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Rnf157 ring finger protein 157 [ Mus musculus (house mouse) ]

Gene ID: 217340, updated on 8-Dec-2022

Summary

Official Symbol
Rnf157provided by MGI
Official Full Name
ring finger protein 157provided by MGI
Primary source
MGI:MGI:2442484
See related
Ensembl:ENSMUSG00000052949 AllianceGenome:MGI:2442484
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
mKIAA1917; 2610036E23Rik; A130073L17Rik
Summary
Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in several processes, including negative regulation of signal transduction; positive regulation of dendrite extension; and protein autoubiquitination. Predicted to be located in cell body. Predicted to be active in early endosome; nucleus; and plasma membrane. Is expressed in future spinal cord. Orthologous to human RNF157 (ring finger protein 157). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in frontal lobe adult (RPKM 39.1), cortex adult (RPKM 38.6) and 14 other tissues See more
Orthologs
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Genomic context

See Rnf157 in Genome Data Viewer
Location:
11; 11 E2
Exon count:
20
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (116227171..116304217, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (116336345..116413391, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 26730 Neighboring gene forkhead box J1 Neighboring gene ribosomal protein S11, pseudogene 2 Neighboring gene UBA-like domain containing 2 Neighboring gene glutamine rich 2

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (2) 
  • Endonuclease-mediated (2)  1 citation

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables ubiquitin protein ligase activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of dendrite extension ISO
Inferred from Sequence Orthology
more info
 
involved_in protein autoubiquitination ISO
Inferred from Sequence Orthology
more info
 
involved_in protein ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in protein ubiquitination ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in cell body ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
E3 ubiquitin ligase Rnf157
Names
RING-type E3 ubiquitin transferase Rnf157
NP_081534.1
XP_006533166.1
XP_006533167.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001405137.1NP_001392066.1  E3 ubiquitin ligase Rnf157 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL645861
  2. NM_001405138.1NP_001392067.1  E3 ubiquitin ligase Rnf157 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL645861
  3. NM_001405139.1NP_001392068.1  E3 ubiquitin ligase Rnf157 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL645861
    UniProtKB/TrEMBL
    A0A6P7RW74
  4. NM_001405140.1NP_001392069.1  E3 ubiquitin ligase Rnf157 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AL645861
  5. NM_001405141.1NP_001392070.1  E3 ubiquitin ligase Rnf157 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AL645861
  6. NM_001405142.1NP_001392071.1  E3 ubiquitin ligase Rnf157 isoform 7

    Status: VALIDATED

    Source sequence(s)
    AL645861
  7. NM_001405143.1NP_001392072.1  E3 ubiquitin ligase Rnf157 isoform 8

    Status: VALIDATED

    Source sequence(s)
    AL645861
  8. NM_001405144.1NP_001392073.1  E3 ubiquitin ligase Rnf157 isoform 9

    Status: VALIDATED

    Source sequence(s)
    AL645861
  9. NM_001405145.1NP_001392074.1  E3 ubiquitin ligase Rnf157 isoform 10

    Status: VALIDATED

    Source sequence(s)
    AL645861
  10. NM_027258.2NP_081534.1  E3 ubiquitin ligase Rnf157 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL645861
    Consensus CDS
    CCDS48984.1
    UniProtKB/TrEMBL
    A2AAN9
    Related
    ENSMUSP00000097776.4, ENSMUST00000100202.10
    Conserved Domains (1) summary
    pfam13920
    Location:276318
    zf-C3HC4_3; Zinc finger, C3HC4 type (RING finger)

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    116227171..116304217 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006533104.2XP_006533167.1  E3 ubiquitin ligase Rnf157 isoform X2

    Conserved Domains (3) summary
    cd16789
    Location:276316
    mRING-HC-C3HC5_MGRN1_like---blasttree; Modified RING finger, HC subclass (C3HC5-type), found in mahogunin RING finger protein 1 (MGRN1), RING finger protein 157 (RNF157) and similar proteins
    pfam15324
    Location:530594
    TALPID3; Hedgehog signalling target
    cl29320
    Location:236330
    KilA-N; KilA-N domain
  2. XM_006533103.3XP_006533166.1  E3 ubiquitin ligase Rnf157 isoform X1

    Conserved Domains (3) summary
    cd16789
    Location:276316
    mRING-HC-C3HC5_MGRN1_like---blasttree; Modified RING finger, HC subclass (C3HC5-type), found in mahogunin RING finger protein 1 (MGRN1), RING finger protein 157 (RNF157) and similar proteins
    pfam15324
    Location:530605
    TALPID3; Hedgehog signalling target
    cl29320
    Location:236330
    KilA-N; KilA-N domain