Rnf157 ring finger protein 157 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Rnf157provided by MGI
Official Full Name: ring finger protein 157provided by MGI
Primary source: MGI:MGI:2442484
See related: Ensembl:ENSMUSG00000052949 AllianceGenome:MGI:2442484
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: mKIAA1917; 2610036E23Rik; A130073L17Rik
Summary: Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in several processes, including negative regulation of signal transduction; positive regulation of dendrite extension; and protein autoubiquitination. Predicted to be located in cell body. Predicted to be active in early endosome; nucleus; and plasma membrane. Is expressed in future spinal cord. Orthologous to human RNF157 (ring finger protein 157). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in frontal lobe adult (RPKM 39.1), cortex adult (RPKM 38.6) and 14 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11; 11 E2

Exon count:: 20

Annotation release	Status	Assembly	Chr	Location
109	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (116227171..116304217, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (116336345..116413391, complement)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

RNF157 has a dual role in neurons as it is also required for dendrite growth and maintenance for which its ligase activity is not critical.
Title: Regulation of neuronal survival and morphology by the E3 ubiquitin ligase RNF157.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (1)
Targeted (2)
Endonuclease-mediated (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D11Dcr30 (e-PCR), detects polymorphism
- UniSTS:507475

MT2483 (e-PCR)
- UniSTS:126404

D11Mit203.1 (e-PCR), detects polymorphism
- UniSTS:126405

05.MMHAP66FRB8.seq (e-PCR)
- UniSTS:122829

NoName (e-PCR)
- UniSTS:236782

Homology

Homologs of the Rnf157 gene: The Rnf157 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, rat, chicken, zebrafish, and frog.
Orthologs from Annotation Pipeline: 456 organisms have orthologs with human gene Rnf157
Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transferase activity	IEA Inferred from Electronic Annotation more info
enables ubiquitin protein ligase activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables ubiquitin protein ligase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in negative regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of dendrite extension	ISO Inferred from Sequence Orthology more info
involved_in protein autoubiquitination	ISO Inferred from Sequence Orthology more info
involved_in protein ubiquitination	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in protein ubiquitination	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cell body	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: E3 ubiquitin ligase Rnf157

Names: RING-type E3 ubiquitin transferase Rnf157

NP_081534.1

EC 2.3.2.27

XP_006533166.1

EC 2.3.2.27

XP_006533167.1

EC 2.3.2.27

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001405137.1 → NP_001392066.1 E3 ubiquitin ligase Rnf157 isoform 2

Status: VALIDATED

Source sequence(s)

AL645861
NM_001405138.1 → NP_001392067.1 E3 ubiquitin ligase Rnf157 isoform 3

Status: VALIDATED

Source sequence(s)

AL645861
NM_001405139.1 → NP_001392068.1 E3 ubiquitin ligase Rnf157 isoform 4

Status: VALIDATED

Source sequence(s)

AL645861

UniProtKB/TrEMBL

A0A6P7RW74
NM_001405140.1 → NP_001392069.1 E3 ubiquitin ligase Rnf157 isoform 5

Status: VALIDATED

Source sequence(s)

AL645861
NM_001405141.1 → NP_001392070.1 E3 ubiquitin ligase Rnf157 isoform 6

Status: VALIDATED

Source sequence(s)

AL645861
NM_001405142.1 → NP_001392071.1 E3 ubiquitin ligase Rnf157 isoform 7

Status: VALIDATED

Source sequence(s)

AL645861
NM_001405143.1 → NP_001392072.1 E3 ubiquitin ligase Rnf157 isoform 8

Status: VALIDATED

Source sequence(s)

AL645861
NM_001405144.1 → NP_001392073.1 E3 ubiquitin ligase Rnf157 isoform 9

Status: VALIDATED

Source sequence(s)

AL645861
NM_001405145.1 → NP_001392074.1 E3 ubiquitin ligase Rnf157 isoform 10

Status: VALIDATED

Source sequence(s)

AL645861
NM_027258.2 → NP_081534.1 E3 ubiquitin ligase Rnf157 isoform 1

Status: VALIDATED

Source sequence(s)

AL645861

Consensus CDS

CCDS48984.1

UniProtKB/TrEMBL

A2AAN9

Related

ENSMUSP00000097776.4, ENSMUST00000100202.10

Conserved Domains (1) summary

pfam13920
Location:276 → 318

zf-C3HC4_3; Zinc finger, C3HC4 type (RING finger)

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000077.7 Reference GRCm39 C57BL/6J

Range

116227171..116304217 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006533104.2 → XP_006533167.1 E3 ubiquitin ligase Rnf157 isoform X2

Conserved Domains (3) summary

cd16789
Location:276 → 316

mRING-HC-C3HC5_MGRN1_like---blasttree; Modified RING finger, HC subclass (C3HC5-type), found in mahogunin RING finger protein 1 (MGRN1), RING finger protein 157 (RNF157) and similar proteins

pfam15324
Location:530 → 594

TALPID3; Hedgehog signalling target

cl29320
Location:236 → 330

KilA-N; KilA-N domain
XM_006533103.3 → XP_006533166.1 E3 ubiquitin ligase Rnf157 isoform X1

Conserved Domains (3) summary

cd16789
Location:276 → 316

mRING-HC-C3HC5_MGRN1_like---blasttree; Modified RING finger, HC subclass (C3HC5-type), found in mahogunin RING finger protein 1 (MGRN1), RING finger protein 157 (RNF157) and similar proteins

pfam15324
Location:530 → 605

TALPID3; Hedgehog signalling target

cl29320
Location:236 → 330

KilA-N; KilA-N domain