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Ace3 angiotensin I converting enzyme (peptidyl-dipeptidase A) 3 [ Mus musculus (house mouse) ]

Gene ID: 217246, updated on 23-May-2018

Summary

Official Symbol
Ace3provided by MGI
Official Full Name
angiotensin I converting enzyme (peptidyl-dipeptidase A) 3provided by MGI
Primary source
MGI:MGI:3644400
See related
Ensembl:ENSMUSG00000101605 Vega:OTTMUSG00000033693
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
EG217246
Expression
Restricted expression toward testis adult (RPKM 16.2) See more

Genomic context

See Ace3 in Genome Data Viewer
Location:
11; 11 E1
Exon count:
16
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 11 NC_000077.6 (105994419..106007501)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (105856045..105866757)

Chromosome 11 - NC_000077.6Genomic Context describing neighboring genes Neighboring gene cytochrome b-561 Neighboring gene predicted gene, 46296 Neighboring gene predicted gene 11651 Neighboring gene angiotensin I converting enzyme (peptidyl-dipeptidase A) 1 Neighboring gene predicted gene, 35971 Neighboring gene potassium voltage-gated channel, subfamily H (eag-related), member 6 Neighboring gene DDB1 and CUL4 associated factor 7

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from BioSystems

  • Chagas disease (American trypanosomiasis), organism-specific biosystem (from KEGG)
    Chagas disease (American trypanosomiasis), organism-specific biosystemTrypanosoma cruzi is an intracellular protozoan parasite that causes Chagas disease. The parasite life cycle involves hematophagous reduviid bugs as vectors. Once parasites enter the host body, they ...
  • Chagas disease (American trypanosomiasis), conserved biosystem (from KEGG)
    Chagas disease (American trypanosomiasis), conserved biosystemTrypanosoma cruzi is an intracellular protozoan parasite that causes Chagas disease. The parasite life cycle involves hematophagous reduviid bugs as vectors. Once parasites enter the host body, they ...
  • Hypertrophic cardiomyopathy (HCM), organism-specific biosystem (from KEGG)
    Hypertrophic cardiomyopathy (HCM), organism-specific biosystemHypertrophic cardiomyopathy (HCM) is a primary myocardial disorder with an autosomal dominant pattern of inheritance that is characterized by hypertrophy of the left ventricles with histological feat...
  • Hypertrophic cardiomyopathy (HCM), conserved biosystem (from KEGG)
    Hypertrophic cardiomyopathy (HCM), conserved biosystemHypertrophic cardiomyopathy (HCM) is a primary myocardial disorder with an autosomal dominant pattern of inheritance that is characterized by hypertrophy of the left ventricles with histological feat...
  • Renin secretion, organism-specific biosystem (from KEGG)
    Renin secretion, organism-specific biosystemThe aspartyl-protease renin is the key regulator of the renin-angiotensin-aldosterone system, which is critically involved in extracellular fluid volume and blood pressure homeostasis of the body. R...
  • Renin secretion, conserved biosystem (from KEGG)
    Renin secretion, conserved biosystemThe aspartyl-protease renin is the key regulator of the renin-angiotensin-aldosterone system, which is critically involved in extracellular fluid volume and blood pressure homeostasis of the body. R...
  • Renin-angiotensin system, organism-specific biosystem (from KEGG)
    Renin-angiotensin system, organism-specific biosystemThe renin-angiotensin system (RAS) is a peptidergic system with endocrine characteristics regarding to the regulation of the blood pressure and hydro-electrolytic balance. In the classical RAS, the ...
  • Renin-angiotensin system, conserved biosystem (from KEGG)
    Renin-angiotensin system, conserved biosystemThe renin-angiotensin system (RAS) is a peptidergic system with endocrine characteristics regarding to the regulation of the blood pressure and hydro-electrolytic balance. In the classical RAS, the ...

General gene information

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
dipeptidyl-peptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
exopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
metallopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
metallopeptidase activity IEA
Inferred from Electronic Annotation
more info
 
peptidyl-dipeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
peptidyl-dipeptidase activity IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
biological_process ND
No biological Data available
more info
 
positive regulation of blood pressure IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of systemic arterial blood pressure IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
proteolysis IEA
Inferred from Electronic Annotation
more info
 
regulation of systemic arterial blood pressure by renin-angiotensin IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
acrosomal vesicle IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
 
extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
angiotensin-converting enzyme-like protein Ace3; angiotensin I converting enzyme 3
NP_001094923.2
XP_006533116.1
XP_006533117.1
XP_006533118.1
XP_006533119.1
XP_006533121.1
XP_006533122.1
XP_006533123.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001101453.2NP_001094923.2  angiotensin-converting enzyme-like protein Ace3 precursor

    See identical proteins and their annotated locations for NP_001094923.2

    Status: VALIDATED

    Source sequence(s)
    AB531024
    Consensus CDS
    CCDS59570.1
    UniProtKB/Swiss-Prot
    D0G895
    Related
    ENSMUSP00000140827.1, OTTMUSP00000062952, ENSMUST00000190995.1, OTTMUST00000084872
    Conserved Domains (1) summary
    pfam01401
    Location:33609
    Peptidase_M2; Angiotensin-converting enzyme

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000077.6 Reference GRCm38.p4 C57BL/6J

    Range
    105994419..106007501
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006533054.3XP_006533117.1  angiotensin I converting enzyme 3 isoform X2

    Conserved Domains (1) summary
    pfam01401
    Location:52635
    Peptidase_M2; Angiotensin-converting enzyme
  2. XM_006533053.3XP_006533116.1  angiotensin I converting enzyme 3 isoform X1

    Conserved Domains (1) summary
    pfam01401
    Location:52647
    Peptidase_M2; Angiotensin-converting enzyme
  3. XM_006533056.3XP_006533119.1  angiotensin I converting enzyme 3 isoform X4

    Conserved Domains (1) summary
    pfam01401
    Location:52618
    Peptidase_M2; Angiotensin-converting enzyme
  4. XM_006533058.3XP_006533121.1  angiotensin I converting enzyme 3 isoform X5

    Conserved Domains (1) summary
    pfam01401
    Location:52595
    Peptidase_M2; Angiotensin-converting enzyme
  5. XM_006533059.3XP_006533122.1  angiotensin I converting enzyme 3 isoform X6

    Conserved Domains (1) summary
    pfam01401
    Location:52594
    Peptidase_M2; Angiotensin-converting enzyme
  6. XM_006533060.3XP_006533123.1  angiotensin I converting enzyme 3 isoform X7

    Conserved Domains (1) summary
    cl14813
    Location:52397
    GluZincin; Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins)
  7. XM_006533055.3XP_006533118.1  angiotensin I converting enzyme 3 isoform X3

    Conserved Domains (1) summary
    pfam01401
    Location:52628
    Peptidase_M2; Angiotensin-converting enzyme

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NG_012394.1: Suppressed sequence

    Description
    NG_012394.1: This RefSeq was permanently suppressed because it is now thought that this gene does encode a protein.
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