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Hrob homologous recombination factor with OB-fold [ Mus musculus (house mouse) ]

Gene ID: 217216, updated on 5-Mar-2024

Summary

Official Symbol
Hrobprovided by MGI
Official Full Name
homologous recombination factor with OB-foldprovided by MGI
Primary source
MGI:MGI:2387601
See related
Ensembl:ENSMUSG00000034773 AllianceGenome:MGI:2387601
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Enables single-stranded DNA binding activity. Involved in female gamete generation and male gamete generation. Predicted to be located in site of DNA damage. Orthologous to human HROB (homologous recombination factor with OB-fold). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in testis adult (RPKM 16.1), liver E14.5 (RPKM 5.6) and 13 other tissues See more
Orthologs
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Genomic context

Location:
11 D; 11 66.21 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (102139677..102156009)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (102248857..102265183)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene glucose 6 phosphatase, catalytic, 3 Neighboring gene histone deacetylase 5 Neighboring gene STARR-positive B cell enhancer ABC_E378 Neighboring gene microRNA 8101 Neighboring gene STARR-positive B cell enhancer ABC_E911 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:102128926-102129035 Neighboring gene ankyrin repeat and SOCS box-containing 16 Neighboring gene STARR-positive B cell enhancer ABC_E1432 Neighboring gene transmembrane and ubiquitin-like domain containing 2 Neighboring gene ataxin 7-like 3

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

General gene information

Clone Names

  • MGC31269, MGC117894

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables single-stranded DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within DNA biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
involved_in DNA damage response ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within DNA recombination IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within DNA repair IEA
Inferred from Electronic Annotation
more info
 
involved_in DNA synthesis involved in DNA repair ISO
Inferred from Sequence Orthology
more info
 
involved_in female gamete generation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in interstrand cross-link repair ISO
Inferred from Sequence Orthology
more info
 
involved_in male gamete generation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in recombinational repair IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in chromosome IEA
Inferred from Electronic Annotation
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
located_in site of DNA damage ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
homologous recombination OB-fold protein
Names
uncharacterized protein C17orf53 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_153544.3NP_705772.3  homologous recombination OB-fold protein

    See identical proteins and their annotated locations for NP_705772.3

    Status: VALIDATED

    Source sequence(s)
    AK029811, AL954730, BB610688
    Consensus CDS
    CCDS36342.1
    UniProtKB/Swiss-Prot
    A2AWS8, Q32P12, Q8CDN3
    Related
    ENSMUSP00000097961.5, ENSMUST00000100392.5
    Conserved Domains (2) summary
    PHA03195
    Location:1780
    PHA03195; tegument protein VP11/12; Provisional
    pfam15072
    Location:458539
    DUF4539; Domain of unknown function (DUF4539)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    102139677..102156009
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006533040.3XP_006533103.1  homologous recombination OB-fold protein isoform X1

    Conserved Domains (2) summary
    PHA03247
    Location:44374
    PHA03247; large tegument protein UL36; Provisional
    pfam15072
    Location:459540
    DUF4539; Domain of unknown function (DUF4539)
  2. XM_030245876.1XP_030101736.1  homologous recombination OB-fold protein isoform X2

    Conserved Domains (2) summary
    PHA03247
    Location:135294
    PHA03247; large tegument protein UL36; Provisional
    pfam15072
    Location:379460
    DUF4539; Domain of unknown function (DUF4539)
  3. XM_036156591.1XP_036012484.1  homologous recombination OB-fold protein isoform X3

    Conserved Domains (2) summary
    PHA03247
    Location:135294
    PHA03247; large tegument protein UL36; Provisional
    pfam15072
    Location:378459
    DUF4539; Domain of unknown function (DUF4539)
  4. XM_030245878.1XP_030101738.1  homologous recombination OB-fold protein isoform X2

    Conserved Domains (2) summary
    PHA03247
    Location:135294
    PHA03247; large tegument protein UL36; Provisional
    pfam15072
    Location:379460
    DUF4539; Domain of unknown function (DUF4539)
  5. XM_017314483.3XP_017169972.1  homologous recombination OB-fold protein isoform X4

    Conserved Domains (1) summary
    pfam15072
    Location:94175
    DUF4539; Domain of unknown function (DUF4539)

RNA

  1. XR_004936928.1 RNA Sequence

  2. XR_004936929.1 RNA Sequence

    Related
    ENSMUST00000133930.8