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Cisd3 CDGSH iron sulfur domain 3 [ Mus musculus (house mouse) ]

Gene ID: 217149, updated on 26-Sep-2022

Summary

Official Symbol
Cisd3provided by MGI
Official Full Name
CDGSH iron sulfur domain 3provided by MGI
Primary source
MGI:MGI:101788
See related
Ensembl:ENSMUSG00000078695 AllianceGenome:MGI:101788
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Mel13; Mel-13
Summary
Predicted to enable 2 iron, 2 sulfur cluster binding activity and metal ion binding activity. Predicted to be involved in protein maturation by [2Fe-2S] cluster transfer. Located in mitochondrion. Orthologous to human CISD3 (CDGSH iron sulfur domain 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in large intestine adult (RPKM 67.3), duodenum adult (RPKM 51.1) and 19 other tissues See more
Orthologs
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Genomic context

See Cisd3 in Genome Data Viewer
Location:
11; 11 D
Exon count:
4
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (97576291..97579451)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (97685465..97688625)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene predicted gene 11613 Neighboring gene myeloid/lymphoid or mixed-lineage leukemia; translocated to, 6 Neighboring gene microRNA 6927 Neighboring gene polycomb group ring finger 2 Neighboring gene nuclear encoded tRNA asparagine 8 (anticodon GTT)

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 2 iron, 2 sulfur cluster binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables 2 iron, 2 sulfur cluster binding ISO
Inferred from Sequence Orthology
more info
 
enables iron-sulfur cluster binding IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in protein maturation by [2Fe-2S] cluster transfer IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in protein maturation by [2Fe-2S] cluster transfer ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in intracellular membrane-bounded organelle IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
PubMed 

General protein information

Preferred Names
CDGSH iron-sulfur domain-containing protein 3, mitochondrial
Names
melanoma nuclear protein 13

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001085500.3NP_001078969.2  CDGSH iron-sulfur domain-containing protein 3, mitochondrial isoform 2 precursor

    See identical proteins and their annotated locations for NP_001078969.2

    Status: VALIDATED

    Source sequence(s)
    AA987107, AI414532, BC056217
    Consensus CDS
    CCDS48896.1
    UniProtKB/Swiss-Prot
    B1AR12, B1AR13
    Related
    ENSMUSP00000103209.3, ENSMUST00000107583.3
    Conserved Domains (2) summary
    pfam09360
    Location:5685
    zf-CDGSH; Iron-binding zinc finger CDGSH type
    cl02748
    Location:93129
    zf-CDGSH; Iron-binding zinc finger CDGSH type
  2. NM_001364153.1NP_001351082.1  CDGSH iron-sulfur domain-containing protein 3, mitochondrial isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL596123, BC147739
    Conserved Domains (1) summary
    pfam09360
    Location:136165
    zf-CDGSH; Iron-binding zinc finger CDGSH type

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    97576291..97579451
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006533029.3XP_006533092.1  CDGSH iron-sulfur domain-containing protein 3, mitochondrial isoform X1

    Conserved Domains (1) summary
    pfam09360
    Location:117146
    zf-CDGSH; Iron-binding zinc finger CDGSH type