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Hlf hepatic leukemia factor [ Mus musculus (house mouse) ]

Gene ID: 217082, updated on 7-Feb-2023

Summary

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Official Symbol
Hlfprovided by MGI
Official Full Name
hepatic leukemia factorprovided by MGI
Primary source
MGI:MGI:96108
See related
Ensembl:ENSMUSG00000003949 AllianceGenome:MGI:96108
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
E230015K02Rik
Summary
Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within skeletal muscle cell differentiation. Predicted to be located in nucleoplasm. Predicted to be active in nucleus. Is expressed in several structures, including alimentary system; genitourinary system; heart; nervous system; and sensory organ. Orthologous to human HLF (HLF transcription factor, PAR bZIP family member). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in cortex adult (RPKM 20.3), frontal lobe adult (RPKM 15.0) and 16 other tissues See more
Orthologs
human all
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Genomic context

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See Hlf in Genome Data Viewer
Location:
11 C; 11 55.03 cM
Exon count:
6
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (90227361..90281743, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (90336535..90390917, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 42089 Neighboring gene monocyte to macrophage differentiation-associated Neighboring gene predicted gene, 34850 Neighboring gene syntaxin binding protein 4 Neighboring gene eukaryotic translation initiation factor 2C, 2 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Bone marrow imaging reveals the migration dynamics of neonatal hematopoietic stem cells. Takihara Y, et al. Commun Biol, 2022 Aug 2. PMID 35918480, Free PMC Article
  2. Aberrant expression of PAR bZIP transcription factors is associated with epileptogenesis, focus on hepatic leukemia factor. Rambousek L, et al. Sci Rep, 2020 Feb 28. PMID 32111960, Free PMC Article
  3. Hepatic Leukemia Factor Maintains Quiescence of Hematopoietic Stem Cells and Protects the Stem Cell Pool during Regeneration. Komorowska K, et al. Cell Rep, 2017 Dec 19. PMID 29262330
  4. Hlf is a genetic modifier of epilepsy caused by voltage-gated sodium channel mutations. Hawkins NA, et al. Epilepsy Res, 2016 Jan. PMID 26656780, Free PMC Article
  5. Conditional Expression of E2A-HLF Induces B-Cell Precursor Death and Myeloproliferative-Like Disease in Knock-In Mice. Duque-Afonso J, et al. PLoS One, 2015. PMID 26588248, Free PMC Article

See all (48) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Aberrant expression of PAR bZIP transcription factors is associated with epileptogenesis, focus on hepatic leukemia factor.
    Title: Aberrant expression of PAR bZIP transcription factors is associated with epileptogenesis, focus on hepatic leukemia factor.
  2. marks the developmental pathway for hematopoietic stem cells but not for erythro-myeloid progenitors
    Title: Hlf marks the developmental pathway for hematopoietic stem cells but not for erythro-myeloid progenitors.
  3. HLF-deficient hematopoietic stem cells display loss of quiescence and increased sensitivity to chemotoxic insults.
    Title: Hepatic Leukemia Factor Maintains Quiescence of Hematopoietic Stem Cells and Protects the Stem Cell Pool during Regeneration.
  4. Results demonstrate that Hlf is a genetic modifier of epilepsy caused by voltage-gated sodium channel mutations and that modulation of the pyridoxine pathway can also influence phenotype severity
    Title: Hlf is a genetic modifier of epilepsy caused by voltage-gated sodium channel mutations.
  5. Conditional expression of E2A-HLF induces B-cell precursor death and myeloproliferative-like disease in knock-in mice.
    Title: Conditional Expression of E2A-HLF Induces B-Cell Precursor Death and Myeloproliferative-Like Disease in Knock-In Mice.
  6. Data indicate that Meis homeobox 1 (MEIS1) is required for the maintenance of myeloid-lymphoid leukemia protein MLL-fusion gene leukemia, and hepatic leukemia factor (HLF)is a key downstream mediator of Meis1.
    Title: MEIS1 regulates an HLF-oxidative stress axis in MLL-fusion gene leukemia.
  7. we demonstrate that D site albumin promoter binding protein/thyrotroph embryonic factor/hepatic leukemia factor triple knockout mice develop cardiac hypertrophy and left ventricular dysfunction associated with a low blood pressure
    Title: Cardiac hypertrophy, low blood pressure, and low aldosterone levels in mice devoid of the three circadian PAR bZip transcription factors DBP, HLF, and TEF.
  8. Data show that the clock knockout mice or mice devoid of dbp/hlf/tef (triple knockout) exhibit significant changes in renal expression of several key regulators of water or sodium balance.
    Title: Molecular clock is involved in predictive circadian adjustment of renal function.
  9. mice deficient for all three PAR bZip proteins (DBP,HLF,& TEF) are highly susceptible to generalized spontaneous and audiogenic epilepsies, frequently lethal. Pyridoxal kinase is a target gene of PAR bZip proteins in both liver and brain
    Title: The loss of circadian PAR bZip transcription factors results in epilepsy.
  10. The HLF protein control the expression of many enzymes and regulators involved in detoxification and drug metabolism, such as cytochrome P450 enzymes, carboxylesterases, and constitutive androstane receptor (CAR).
    Title: The circadian PAR-domain basic leucine zipper transcription factors DBP, TEF, and HLF modulate basal and inducible xenobiotic detoxification.
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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription activator activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
  
enables DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
enables sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables sequence-specific double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
acts_upstream_of_or_within rhythmic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within skeletal muscle cell differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of RNA polymerase II transcription regulator complex ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 

General protein information

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Preferred Names
hepatic leukemia factor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001403985.1 → NP_001390914.1  hepatic leukemia factor isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL626785, AL691494
    UniProtKB/TrEMBL
    A0A6P5QVA9

  2. NM_001403986.1 → NP_001390915.1  hepatic leukemia factor isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL626785, AL691494

  3. NM_001403988.1 → NP_001390917.1  hepatic leukemia factor isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL626785, AL691494

  4. NM_001403989.1 → NP_001390918.1  hepatic leukemia factor isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL626785, AL691494

  5. NM_001403991.1 → NP_001390920.1  hepatic leukemia factor isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL626785, AL691494

  6. NM_001403993.1 → NP_001390922.1  hepatic leukemia factor isoform 5

    Status: VALIDATED

    Source sequence(s)
    AL626785, AL691494

  7. NM_001403995.1 → NP_001390924.1  hepatic leukemia factor isoform 5

    Status: VALIDATED

    Source sequence(s)
    AL626785, AL691494

  8. NM_001403997.1 → NP_001390926.1  hepatic leukemia factor isoform 5

    Status: VALIDATED

    Source sequence(s)
    AL626785, AL691494

  9. NM_172563.4 → NP_766151.1  hepatic leukemia factor isoform 1

    See identical proteins and their annotated locations for NP_766151.1

    Status: VALIDATED

    Source sequence(s)
    AL626785, AL691494
    Consensus CDS
    CCDS25241.1
    UniProtKB/Swiss-Prot
    Q6PF83, Q8BW74
    UniProtKB/TrEMBL
    A0A6P5QPF5, A0A8C6IIB9
    Related
    ENSMUSP00000004051.8, ENSMUST00000004051.8
    Conserved Domains (1) summary
    cd14695
    Location:224 → 283
    bZIP_HLF; Basic leucine zipper (bZIP) domain of Hepatic leukemia factor (HLF) and similar proteins: a DNA-binding and dimerization domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    90227361..90281743 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006533004.2 → XP_006533067.1  hepatic leukemia factor isoform X1

    Conserved Domains (1) summary
    cd14695
    Location:226 → 284
    bZIP_HLF; Basic leucine zipper (bZIP) domain of Hepatic leukemia factor (HLF) and similar proteins: a DNA-binding and dimerization domain

  2. XM_006533007.3 → XP_006533070.1  hepatic leukemia factor isoform X3

    Conserved Domains (2) summary
    cd14695
    Location:139 → 198
    bZIP_HLF; Basic leucine zipper (bZIP) domain of Hepatic leukemia factor (HLF) and similar proteins: a DNA-binding and dimerization domain
    pfam09606
    Location:10 → 77
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal

  3. XM_006533005.4 → XP_006533068.1  hepatic leukemia factor isoform X2

    UniProtKB/Swiss-Prot
    Q8BW74
    Conserved Domains (1) summary
    cd14695
    Location:141 → 199
    bZIP_HLF; Basic leucine zipper (bZIP) domain of Hepatic leukemia factor (HLF) and similar proteins: a DNA-binding and dimerization domain

  4. XM_030245856.1 → XP_030101716.1  hepatic leukemia factor isoform X3

    Conserved Domains (2) summary
    cd14695
    Location:139 → 198
    bZIP_HLF; Basic leucine zipper (bZIP) domain of Hepatic leukemia factor (HLF) and similar proteins: a DNA-binding and dimerization domain
    pfam09606
    Location:10 → 77
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal

  5. XM_006533006.1 → XP_006533069.1  hepatic leukemia factor isoform X2

    UniProtKB/Swiss-Prot
    Q8BW74
    Conserved Domains (1) summary
    cd14695
    Location:141 → 199
    bZIP_HLF; Basic leucine zipper (bZIP) domain of Hepatic leukemia factor (HLF) and similar proteins: a DNA-binding and dimerization domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BW74.1 GenPept UniProtKB/Swiss-Prot:Q8BW74

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