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Hlf hepatic leukemia factor [ Mus musculus (house mouse) ]

Gene ID: 217082, updated on 10-Oct-2019

Summary

Official Symbol
Hlfprovided by MGI
Official Full Name
hepatic leukemia factorprovided by MGI
Primary source
MGI:MGI:96108
See related
Ensembl:ENSMUSG00000003949
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
E230015K02Rik
Expression
Broad expression in cortex adult (RPKM 20.3), frontal lobe adult (RPKM 15.0) and 16 other tissues See more
Orthologs

Genomic context

See Hlf in Genome Data Viewer
Location:
11 C; 11 55.03 cM
Exon count:
6
Annotation release Status Assembly Chr Location
108 current GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (90336535..90390917, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (90197849..90252231, complement)

Chromosome 11 - NC_000077.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 42089 Neighboring gene monocyte to macrophage differentiation-associated Neighboring gene predicted gene, 34850 Neighboring gene syntaxin binding protein 4 Neighboring gene eukaryotic translation initiation factor 2C, 2 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
DNA binding IEA
Inferred from Electronic Annotation
more info
 
DNA-binding transcription activator activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
 
DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
 
RNA polymerase II regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
rhythmic process IEA
Inferred from Electronic Annotation
more info
 
skeletal muscle cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_172563.3NP_766151.1  hepatic leukemia factor

    See identical proteins and their annotated locations for NP_766151.1

    Status: VALIDATED

    Source sequence(s)
    AL626785, BC058705, CJ164739
    Consensus CDS
    CCDS25241.1
    UniProtKB/Swiss-Prot
    Q8BW74
    Related
    ENSMUSP00000004051.7, ENSMUST00000004051.7
    Conserved Domains (1) summary
    cd14695
    Location:224283
    bZIP_HLF; Basic leucine zipper (bZIP) domain of Hepatic leukemia factor (HLF) and similar proteins: a DNA-binding and dimerization domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p6 C57BL/6J

Genomic

  1. NC_000077.6 Reference GRCm38.p6 C57BL/6J

    Range
    90336535..90390917 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006533004.1XP_006533067.1  hepatic leukemia factor isoform X1

    Conserved Domains (1) summary
    cd14695
    Location:226284
    bZIP_HLF; Basic leucine zipper (bZIP) domain of Hepatic leukemia factor (HLF) and similar proteins: a DNA-binding and dimerization domain
  2. XM_006533005.3XP_006533068.1  hepatic leukemia factor isoform X2

    See identical proteins and their annotated locations for XP_006533068.1

    UniProtKB/Swiss-Prot
    Q8BW74
    Conserved Domains (1) summary
    cd14695
    Location:141199
    bZIP_HLF; Basic leucine zipper (bZIP) domain of Hepatic leukemia factor (HLF) and similar proteins: a DNA-binding and dimerization domain
  3. XM_006533007.2XP_006533070.1  hepatic leukemia factor isoform X3

    Conserved Domains (2) summary
    cd14695
    Location:139198
    bZIP_HLF; Basic leucine zipper (bZIP) domain of Hepatic leukemia factor (HLF) and similar proteins: a DNA-binding and dimerization domain
    pfam09606
    Location:1077
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
  4. XM_030245856.1XP_030101716.1  hepatic leukemia factor isoform X3

  5. XM_006533006.1XP_006533069.1  hepatic leukemia factor isoform X2

    See identical proteins and their annotated locations for XP_006533069.1

    UniProtKB/Swiss-Prot
    Q8BW74
    Conserved Domains (1) summary
    cd14695
    Location:141199
    bZIP_HLF; Basic leucine zipper (bZIP) domain of Hepatic leukemia factor (HLF) and similar proteins: a DNA-binding and dimerization domain
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