U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Nle1 notchless homolog 1 [ Mus musculus (house mouse) ]

Gene ID: 217011, updated on 26-Sep-2022

Summary

Official Symbol
Nle1provided by MGI
Official Full Name
notchless homolog 1provided by MGI
Primary source
MGI:MGI:2429770
See related
Ensembl:ENSMUSG00000020692 AllianceGenome:MGI:2429770
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Nle; l11Jus1; l11Jus4
Summary
Acts upstream of or within several processes, including chordate embryonic development; hematopoietic stem cell homeostasis; and regulation of signal transduction. Located in nucleolus. Is expressed in several structures, including 2-cell stage embryo; gonad; hemolymphoid system gland; inner cell mass; and liver. Orthologous to human NLE1 (notchless homolog 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in ovary adult (RPKM 23.0), thymus adult (RPKM 15.4) and 28 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Nle1 in Genome Data Viewer
Location:
11; 11 C
Exon count:
13
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (82791594..82799272, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (82900768..82908446, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene RAD51 paralog D Neighboring gene fibronectin type III domain containing 8 Neighboring gene unc-45 myosin chaperone B Neighboring gene unc-45 myosin chaperone B, opposite strand Neighboring gene schlafen 5, opposite strand Neighboring gene schlafen 5

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC25690

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
 
Process Evidence Code Pubs
involved_in Notch signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within Notch signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within Notch signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within hematopoietic stem cell homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within inner cell mass cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within kidney development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of mitotic cell cycle IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of mitotic cell cycle IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of canonical Wnt signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in ribosomal large subunit assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within ribosomal large subunit biogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within skeletal system morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within somitogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
is_active_in nucleolus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleolus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
notchless protein homolog 1
Names
Notchless gene homolog
novel WD40 repeat containing protein

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_145431.2NP_663406.2  notchless protein homolog 1

    See identical proteins and their annotated locations for NP_663406.2

    Status: VALIDATED

    Source sequence(s)
    AI852473, AK141230, BX631936, BY149184
    Consensus CDS
    CCDS25152.1
    UniProtKB/Swiss-Prot
    B1ARD5, Q8VEJ4
    UniProtKB/TrEMBL
    Q3URT5
    Related
    ENSMUSP00000099502.4, ENSMUST00000103213.10
    Conserved Domains (4) summary
    COG2319
    Location:107485
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:106484
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    pfam08154
    Location:1777
    NLE; NLE (NUC135) domain
    sd00039
    Location:159197
    7WD40; WD40 repeat [structural motif]

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    82791594..82799272 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030245842.1XP_030101702.1  notchless protein homolog 1 isoform X1

    Conserved Domains (3) summary
    COG2319
    Location:1099
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:58394
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:69107
    7WD40; WD40 repeat [structural motif]

RNA

  1. XR_004936923.1 RNA Sequence

  2. XR_003949391.1 RNA Sequence

  3. XR_388409.3 RNA Sequence

  4. XR_879591.2 RNA Sequence

  5. XR_003949392.1 RNA Sequence

  6. XR_004936925.1 RNA Sequence

  7. XR_004936924.1 RNA Sequence

  8. XR_004936922.1 RNA Sequence