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Wscd1 WSC domain containing 1 [ Mus musculus (house mouse) ]

Gene ID: 216881, updated on 9-May-2024

Summary

Official Symbol
Wscd1provided by MGI
Official Full Name
WSC domain containing 1provided by MGI
Primary source
MGI:MGI:2448493
See related
Ensembl:ENSMUSG00000020811 AllianceGenome:MGI:2448493
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
mKIAA0523
Summary
Predicted to enable sulfotransferase activity. Predicted to be located in membrane. Predicted to be integral component of membrane. Is expressed in several structures, including genitourinary system; nervous system; sensory organ; tooth; and ventricle cardiac muscle. Orthologous to human WSCD1 (WSC domain containing 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in cerebellum adult (RPKM 18.0), lung adult (RPKM 15.1) and 14 other tissues See more
Orthologs
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Genomic context

See Wscd1 in Genome Data Viewer
Location:
11 B4; 11 43.62 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (71640719..71680475)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (71749893..71789649)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 33964 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:71483619-71483785 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:71483854-71484055 Neighboring gene STARR-seq mESC enhancer starr_29891 Neighboring gene STARR-seq mESC enhancer starr_29892 Neighboring gene predicted gene 12326 Neighboring gene STARR-seq mESC enhancer starr_29893 Neighboring gene predicted gene, 34127 Neighboring gene predicted gene, 22927

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (2) 

General gene information

Clone Names

  • KIAA0523, MGC55022

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
 
enables sulfotransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
 
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
 
located_in Golgi membrane IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in cellular_component ND
No biological Data available
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
sialate:O-sulfotransferase 1
Names
WSC domain-containing protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001357960.1NP_001344889.1  sialate:O-sulfotransferase 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 3. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    BC063070, BM949874, BQ043204, BY267133
    Consensus CDS
    CCDS24975.1
    UniProtKB/Swiss-Prot
    Q3TQ40, Q5DU24, Q80XH4, Q8BX34
    Conserved Domains (2) summary
    smart00321
    Location:139231
    WSC; present in yeast cell wall integrity and stress response component proteins
    cl21551
    Location:422551
    Sulfotransfer_3; Sulfotransferase family
  2. NM_001357965.1NP_001344894.1  sialate:O-sulfotransferase 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) represents the longest transcript. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    BB647482, BC063070, BQ043204, CX219865
    Consensus CDS
    CCDS24975.1
    UniProtKB/Swiss-Prot
    Q3TQ40, Q5DU24, Q80XH4, Q8BX34
    Related
    ENSMUSP00000104151.2, ENSMUST00000108511.8
    Conserved Domains (2) summary
    smart00321
    Location:139231
    WSC; present in yeast cell wall integrity and stress response component proteins
    cl21551
    Location:422551
    Sulfotransfer_3; Sulfotransferase family
  3. NM_177618.4NP_808286.2  sialate:O-sulfotransferase 1

    See identical proteins and their annotated locations for NP_808286.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) differs in the 5' UTR, compared to variant 3. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    BC063070
    Consensus CDS
    CCDS24975.1
    UniProtKB/Swiss-Prot
    Q3TQ40, Q5DU24, Q80XH4, Q8BX34
    Related
    ENSMUSP00000021168.8, ENSMUST00000021168.14
    Conserved Domains (2) summary
    smart00321
    Location:139231
    WSC; present in yeast cell wall integrity and stress response component proteins
    cl21551
    Location:422551
    Sulfotransfer_3; Sulfotransferase family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    71640719..71680475
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006532929.4XP_006532992.1  sialate:O-sulfotransferase 1 isoform X1

    See identical proteins and their annotated locations for XP_006532992.1

    UniProtKB/Swiss-Prot
    Q3TQ40, Q5DU24, Q80XH4, Q8BX34
    Conserved Domains (2) summary
    smart00321
    Location:139231
    WSC; present in yeast cell wall integrity and stress response component proteins
    cl21551
    Location:422551
    Sulfotransfer_3; Sulfotransferase family
  2. XM_036156577.1XP_036012470.1  sialate:O-sulfotransferase 1 isoform X1

    UniProtKB/Swiss-Prot
    Q3TQ40, Q5DU24, Q80XH4, Q8BX34
    Conserved Domains (2) summary
    smart00321
    Location:139231
    WSC; present in yeast cell wall integrity and stress response component proteins
    cl21551
    Location:422551
    Sulfotransfer_3; Sulfotransferase family
  3. XM_006532931.5XP_006532994.1  sialate:O-sulfotransferase 1 isoform X1

    See identical proteins and their annotated locations for XP_006532994.1

    UniProtKB/Swiss-Prot
    Q3TQ40, Q5DU24, Q80XH4, Q8BX34
    Related
    ENSMUSP00000104150.2, ENSMUST00000108510.2
    Conserved Domains (2) summary
    smart00321
    Location:139231
    WSC; present in yeast cell wall integrity and stress response component proteins
    cl21551
    Location:422551
    Sulfotransfer_3; Sulfotransferase family
  4. XM_006532932.4XP_006532995.1  sialate:O-sulfotransferase 1 isoform X2

    Conserved Domains (2) summary
    smart00321
    Location:7102
    WSC; present in yeast cell wall integrity and stress response component proteins
    cl21551
    Location:187316
    Sulfotransfer_3; Sulfotransferase family

RNA

  1. XR_004936917.1 RNA Sequence

  2. XR_003949388.2 RNA Sequence