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Wscd1 WSC domain containing 1 [ Mus musculus (house mouse) ]

Gene ID: 216881, updated on 9-Mar-2023

Summary

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Official Symbol
Wscd1provided by MGI
Official Full Name
WSC domain containing 1provided by MGI
Primary source
MGI:MGI:2448493
See related
Ensembl:ENSMUSG00000020811 AllianceGenome:MGI:2448493
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
mKIAA0523
Summary
Predicted to enable sulfotransferase activity. Predicted to be located in membrane. Predicted to be integral component of membrane. Is expressed in several structures, including genitourinary system; nervous system; sensory organ; tooth; and ventricle cardiac muscle. Orthologous to human WSCD1 (WSC domain containing 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in cerebellum adult (RPKM 18.0), lung adult (RPKM 15.1) and 14 other tissues See more
Orthologs
human all
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Genomic context

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See Wscd1 in Genome Data Viewer
Location:
11; 11 B4
Exon count:
11
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (71640719..71680475)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (71749893..71789649)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 33964 Neighboring gene predicted gene 12326 Neighboring gene predicted gene, 34127 Neighboring gene predicted gene, 22927

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Sulfation of sialic acid is ubiquitous and essential for vertebrate development. Ertunc N, et al. Sci Rep, 2022 Jul 21. PMID 35864127, Free PMC Article
  2. Spatial and temporal analysis of gene expression during growth and fusion of the mouse facial prominences. Feng W, et al. PLoS One, 2009 Dec 16. PMID 20016822, Free PMC Article
  3. Novel genes differentially expressed in cortical regions during late neurogenesis. Mühlfriedel S, et al. Eur J Neurosci, 2007 Jul. PMID 17614941
  4. The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Koscielny G, et al. Nucleic Acids Res, 2014 Jan. PMID 24194600, Free PMC Article
  5. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article

See all (13) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 

General gene information

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Homology

Clone Names

  • KIAA0523, MGC55022

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
enables sulfotransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
located_in Golgi membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cellular_component ND
No biological Data available
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
WSC domain-containing protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001357960.1 → NP_001344889.1  WSC domain-containing protein 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 3. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    BC063070, BM949874, BQ043204, BY267133
    Consensus CDS
    CCDS24975.1
    UniProtKB/Swiss-Prot
    Q8BX34
    Conserved Domains (2) summary
    smart00321
    Location:139 → 231
    WSC; present in yeast cell wall integrity and stress response component proteins
    cl21551
    Location:422 → 551
    Sulfotransfer_3; Sulfotransferase family

  2. NM_001357965.1 → NP_001344894.1  WSC domain-containing protein 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) represents the longest transcript. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    BB647482, BC063070, BQ043204, CX219865
    Consensus CDS
    CCDS24975.1
    UniProtKB/Swiss-Prot
    Q8BX34
    Related
    ENSMUSP00000104151.2, ENSMUST00000108511.8
    Conserved Domains (2) summary
    smart00321
    Location:139 → 231
    WSC; present in yeast cell wall integrity and stress response component proteins
    cl21551
    Location:422 → 551
    Sulfotransfer_3; Sulfotransferase family

  3. NM_177618.4 → NP_808286.2  WSC domain-containing protein 1

    See identical proteins and their annotated locations for NP_808286.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) differs in the 5' UTR, compared to variant 3. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    BC063070
    Consensus CDS
    CCDS24975.1
    UniProtKB/Swiss-Prot
    Q80XH4, Q8BX34
    Related
    ENSMUSP00000021168.8, ENSMUST00000021168.14
    Conserved Domains (2) summary
    smart00321
    Location:139 → 231
    WSC; present in yeast cell wall integrity and stress response component proteins
    cl21551
    Location:422 → 551
    Sulfotransfer_3; Sulfotransferase family

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    71640719..71680475
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006532929.4 → XP_006532992.1  WSC domain-containing protein 1 isoform X1

    See identical proteins and their annotated locations for XP_006532992.1

    UniProtKB/Swiss-Prot
    Q80XH4, Q8BX34
    Conserved Domains (2) summary
    smart00321
    Location:139 → 231
    WSC; present in yeast cell wall integrity and stress response component proteins
    cl21551
    Location:422 → 551
    Sulfotransfer_3; Sulfotransferase family

  2. XM_036156577.1 → XP_036012470.1  WSC domain-containing protein 1 isoform X1

    UniProtKB/Swiss-Prot
    Q8BX34
    Conserved Domains (2) summary
    smart00321
    Location:139 → 231
    WSC; present in yeast cell wall integrity and stress response component proteins
    cl21551
    Location:422 → 551
    Sulfotransfer_3; Sulfotransferase family

  3. XM_006532931.5 → XP_006532994.1  WSC domain-containing protein 1 isoform X1

    See identical proteins and their annotated locations for XP_006532994.1

    UniProtKB/Swiss-Prot
    Q80XH4, Q8BX34
    Related
    ENSMUSP00000104150.2, ENSMUST00000108510.2
    Conserved Domains (2) summary
    smart00321
    Location:139 → 231
    WSC; present in yeast cell wall integrity and stress response component proteins
    cl21551
    Location:422 → 551
    Sulfotransfer_3; Sulfotransferase family

  4. XM_006532932.4 → XP_006532995.1  WSC domain-containing protein 1 isoform X2

    Conserved Domains (2) summary
    smart00321
    Location:7 → 102
    WSC; present in yeast cell wall integrity and stress response component proteins
    cl21551
    Location:187 → 316
    Sulfotransfer_3; Sulfotransferase family

RNA

  1. XR_004936917.1 RNA Sequence

  2. XR_003949388.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q80XH4.1 GenPept UniProtKB/Swiss-Prot:Q80XH4

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